Results 181 to 190 of about 77,321 (327)

NAD+‒circadian rhythm coupling in dementia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang, Jiyeon Lee, Jun‐ping Pan, Rune Enger, Harald Hrubos‐Strøm, Erik S. Musiek, Evandro Fei Fang, Weidong Le   +7 more
wiley   +1 more source

GLP‐1 agonists and the gut microbiome: A bidirectional relationship

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1309-1325, May 2026.
Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research.
Srinivas Kamath, Nicole S. L. Chan, Paul Joyce   +2 more
wiley   +1 more source

Th,-e mechanistic insights into the application of retinoids and possible adjunct therapeutic treatment to androgenic alopecia. [PDF]

Ann Med Surg (Lond)
Irfan H, Raza AA, Chowdhry HA, Mobin MB, Samadi A.   +4 more
europepmc   +1 more source

Video Demonstration of ABCA12‐Related Harlequin Ichthyosis in a Low‐Resource Setting: Case Report and Review of Early Management Challenges

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Harlequin ichthyosis is a rare, life‐threatening neonatal dermatologic emergency that can be confidently diagnosed clinically at birth. Prompt recognition and early supportive management—including thermoregulation, fluid balance, infection prevention, and intensive skin care—are crucial determinants of survival, especially in low‐resource ...
Chukwuka Elendu, Dependable C. Amaechi, Tochi C. Elendu, Emmanuel C. Amaechi, Ijeoma D. Elendu, Emeka H. Okolo, Mbanefo C. Uyanwune   +6 more
wiley   +1 more source

Traumatic Anserine Folliculosis: A Case Report. [PDF]

Cureus
AlAhmadi DF, Alghamdi F, AlZaidi RS, Alwafi SS.   +3 more
europepmc   +1 more source

Comparative Efficacy and Safety of Resmetirom and Efruxifermin for Metabolic Dysfunction‐Associated Steatohepatitis: A Network Meta‐Analysis of Randomized Controlled Trials

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
This meta‐analysis compared Resmetirom and Efruxifermin in patients with MASH, focusing on improvements in key biochemical and non‐invasive markers. Efruxifermin is associated with favourable outcomes with a slightly greater effect on MRI‐PDFF and AST, along with more comparable safety outcomes.
Doha Jaber, Inas Jaber, Ayah Abu Lehia, Thekrayat Asad, Hazem Ayesh   +4 more
wiley   +1 more source

Evidence- and consensus-based guideline on lichen sclerosus. [PDF]

J Dtsch Dermatol Ges
Kirtschig G, Woelber L, Günthert A, Becker K, Ciresa-König A, Fischer B, Fricke-Otto S, Günther C, Hirchenhain C, Köllmann NH, Kreuter A, Malisiewicz B, Neis F, Mon O'Dey D, Ott H, Promm M, Renner R, Schardt AR, Schweizer I, Stein R, Ter-Nedden J, Trutnovsky G, Wand A, Weyandt G, Werner RN, Kinberger M.   +25 more
europepmc   +1 more source

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.

Proceedings of the National Academy of Sciences of the United States of America, 1993
H. Keller, C. Dreyer, J. Medin, A. Mahfoudi, K. Ozato, W. Wahli   +5 more
semanticscholar   +1 more source

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

MedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He, Sinan Xie, Kunlin Xie, Fengwei Gao, Yunshi Cai, Yan Huang, Chang Liu, Hong Wu, Yinghao Lyu, Tian Lan   +9 more
wiley   +1 more source

The Next Generation of Skin Care: Transforming Retinoid Therapeutics. [PDF]

Cells
Łuczak JW, Palusińska M, Maślińska-Gromadka K, Pietrzak D, Szopiński T, Lewicki S, Schenk T, Szymański Ł.   +7 more
europepmc   +1 more source