Results 191 to 200 of about 27,382 (293)

Acute Encephalopathy in a Patient With Chronic Isotretinoin Exposure and Frequent Rizatriptan Use: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Acute encephalopathy in patients with prolonged isotretinoin exposure should prompt careful assessment of undisclosed or non‐prescribed medication use. This case suggests a possible association between high cumulative isotretinoin exposure, frequent daily rizatriptan use, and acute encephalopathy, but does not establish a definitive drug–drug ...
Soheil Roshanzamiri, Mitra Rahimi, Shahin Shadnia, Peyman Erfantalab Evini, Faraz Zandiyeh, Babak Mostafazadeh   +5 more
wiley   +1 more source

Treatment Patterns and Economic Burden in Moderate to Severe Chronic Hand Eczema in the USA: A Real-World Retrospective Claims Analysis. [PDF]

Dermatol Ther (Heidelb)
Armstrong AW, Burne R, Bin Sawad A, Lemyre A, Gauthier-Loiselle M, Guerin A, Vinson T, Milovac B, Balu S.   +8 more
europepmc   +1 more source

Monitoring the Effect of Tributyltin Salicylate and Propionate, Retinoid X Receptor Ligands, on Heat Shock Protein Expression in MDA‐MB‐231 Cells by MALDI MS/MS

Journal of Mass Spectrometry, Volume 61, Issue 8, August 2026.
ABSTRACT Organotin (IV) compounds are known to induce apoptosis via the intrinsic mitochondrial pathway, which is a key mechanism of effective anticancer therapy. Their ability to selectively promote apoptotic cell death highlights their potential as chemotherapeutic agents. In this study, the in vitro effects of two triorganotin compounds, tributyltin
Dana Strouhalova, Dana Macejova, Julius Brtko, Janette Bobalova   +3 more
wiley   +1 more source

Medications That Regulate Pregnane X Receptor: A Systematic Review of Current Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
PRISMA 2020 flow diagram of study selection for this systematic review of medications that regulate the pregnane X receptor (PXR), from 12 236 records screened to 101 included studies. ABSTRACT The pregnane X receptor (PXR) gene encodes a ligand‐activated protein involved with the metabolism and excretion of drugs, toxins, and other xenobiotics.
Petra Czarniak, Rachael Moorin, Jeff Hughes, Karl Gruber, David Youens   +4 more
wiley   +1 more source

Th,-e mechanistic insights into the application of retinoids and possible adjunct therapeutic treatment to androgenic alopecia. [PDF]

Ann Med Surg (Lond)
Irfan H, Raza AA, Chowdhry HA, Mobin MB, Samadi A.   +4 more
europepmc   +1 more source

Chemogenetic Activation of G12 Signaling Thickens the Epidermis With Enhanced Barrier Function

FASEB BioAdvances, Volume 8, Issue 8, August 2026.
In this study, we investigated the role of G12 signaling in the epidermis using a keratinocyte‐specific chemogenetic approach. Activation of G12 signaling promoted keratinocyte differentiation and enhanced epidermal barrier function by upregulating filaggrin, claudin‐1, and ceramide.
Nozomi Kamakura, Natsumi Hirai, Kaito Arai, Yaxin Du, Toshiaki Kogame, Yusuke Ohno, Akio Kihara, Kenji Kabashima, Asuka Inoue   +8 more
wiley   +1 more source

The Next Generation of Skin Care: Transforming Retinoid Therapeutics. [PDF]

Cells
Łuczak JW, Palusińska M, Maślińska-Gromadka K, Pietrzak D, Szopiński T, Lewicki S, Schenk T, Szymański Ł.   +7 more
europepmc   +1 more source

Identification and functional validation of a novel disease‐causing variant in the noncoding region of NYX

Acta Ophthalmologica, Volume 104, Issue 5, Page e555-e564, August 2026.
Abstract Purpose Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of disorders, with ~30% of cases remaining genetically unsolved. Complete congenital stationary night blindness (cCSNB) is a subtype of IRD, usually associated with reduced visual acuity, nystagmus and high myopia.
Filip Spanic, Christelle Michiels, Julien Navarro, Aline Antonio, Christel Condroyer, Camille Andrieu, Billy Gipsy, Sylvie Berthémy‐Pellet, Mathilde Gallice, Isabelle Audo, Christina Zeitz   +10 more
wiley   +1 more source

Immune checkpoint inhibitor-related eruptive keratoacanthoma. [PDF]

CMAJ
Watanabe K, Ota M.
europepmc   +1 more source

Integrating Artificial Intelligence Into Drug Discovery From Medicinal Plants: Current Applications and Infrastructural Challenges

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This review presents a systems‐oriented roadmap for integrating artificial intelligence into medicinal plant drug discovery to overcome persistent bottlenecks like extract complexity. It highlights that advancing toward reproducible therapeutics requires making phytochemical datasets AI‐ready via rigorous harmonization and phyto‐centric foundational ...
Amit Gangwal, Azim Ansari, Mohd Usman Mohd Siddique, Jyotiram Sawale, Suhas Padmane, Raju Wadekar   +5 more
wiley   +1 more source