Results 191 to 200 of about 31,233 (276)

Scaffold Hopping Provides Liver X Receptor Agonist With Preference for the β Subtype

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A scaffold hopping strategy was pursued to enhance the binding pocket engagement and β‐subtype selectivity of liver X receptor agonist 2. The resulting spirocyclic lead compound, (S)‐7, demonstrates superior potency, enhanced potency‐based selectivity for LXRβ, and improved microsomal stability over the existing scaffold.
Annette Kärcher, Fiona L. Motel, Felix F. Lillich, Astrid Kaiser, Ewgenij Proschak, Pascal Heitel   +5 more
wiley   +1 more source

Exploring the potential of tocols and retinoids in authenticating pasture-derived sheep milk and cheese. [PDF]

JDS Commun
Iglesias-Rodrigo N, Ángeles Bustamante M, Aldai N, Lavín P, Manso T, Mantecón ÁR, Barron LJR.   +6 more
europepmc   +1 more source

Intracellular Retinoid-Binding Proteins (CRBP, CRALBP, CRABP) as Emerging Drug Targets in Retinal Disease. [PDF]

Int J Mol Sci
Regmi Bagale L, Kim HJ.
europepmc   +1 more source

Von In‐Silico bis In‐Cerebro – Entwicklung des Orexinrezeptor Antagonisten „Photorexant“ zur Photomodulation In Vitro und im Gehirn der Maus

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Apremilast for Acrodermatitis Continua of Hallopeau: Report of Two Cases and Review of the Literature. [PDF]

J Dermatol
Uchida M, Hamada T, Kawashima H, Yamada T, Arase K, Kondo R, Kurakata A, Sugaya M.   +7 more
europepmc   +1 more source

Sustained clinical remission of epidermolysis bullosa simplex due to a pathogenic KRT14 variant in a 7-year-old girl. [PDF]

JAAD Case Rep
Tayeh SA, Ayoub N.
europepmc   +1 more source

Systemic retinoids for squamous cell carcinoma prevention in renal transplant recipients. [PDF]

J Eur Acad Dermatol Venereol
Bhatnagar A, Wayt I, Zinn Z, Codrea V, Chaudhary V.   +4 more
europepmc   +1 more source

International Expert Consensus on Integrated Skincare Active Ingredients for Pretreatment and Posttreatment Use With Medical Aesthetic Procedures to Enhance Skin Benefits. [PDF]

J Cosmet Dermatol
Bjerring P, Draelos ZD, Fabi SG, Goodman GJ, Hau KC, Haus A, Heydenrych I, Kim J, Lin LC, Sayed K, Sundaram H, Tsubouchi R, Wu Y, Brieva P, Choudhary H, Xiang LF.   +15 more
europepmc   +1 more source

Potential Harms of Ocular and Periorbital Topical Vitamin A Application: A Systematic Review and Meta-Analysis. [PDF]

Invest Ophthalmol Vis Sci
Abbott KS, Kruoch Z, Pucker A, Tichenor AA, Orgill M, Anderson B, Olsen E, Dusek J, Shaughnessy D, Naaman K, Qureshi R.   +10 more
europepmc   +1 more source