Results 21 to 30 of about 30,549 (287)

New Treatment Strategy and Future Research Direction for BRAF-Mutated Cancer. [PDF]

open access: yesCancer Sci
Treatment with BRAF inhibitor plus MEK inhibitor is currently used in BRAF‐mutated various malignancies except colorectal cancer, and treatments with BRAF and/or MEK inhibitors and anti‐EGFR antibody are used in BRAF‐mutated colorectal cancer. Despite recent advances in BRAF‐targeted therapies, their efficacy is still limited.
Takahashi M, Taniguchi SH, Yoshida Y.
europepmc   +2 more sources

Muir-Torre syndrome - Treatment with isotretinoin and interferon alpha-2a can prevent tumour development [PDF]

open access: yes, 2000
Muir-Torre syndrome is a genodermatosis in which multiple internal malignancies are associated with cutaneous sebaceous tumours and kerato-acanthomas. A 57-year-old man presented with multiple sebaceous tumours, kerato-acanthomas, verrucous carcinoma of ...
Graefe, Tim   +3 more
core   +1 more source

Topical Cosmeceutical Retinoids

open access: yes, 2022
A cosmeceutical should be represented a topical preparation sold as a cosmetic but with an observable pharmaceutical action. Retinoids define a class of substances comprising vitamin A (retinol) and its naturally and synthetic derivatives.
Sorg, Olivier   +5 more
core   +1 more source

Revival of the Russian chemical industry during the Soviet period (1917–1927). Part 4

open access: yesРазработка и регистрация лекарственных средств, 2022
The fourth chapter presents V. N. Ipatiev's memoirs about the preparation and celebration of the 200th anniversary of the Russian Academy of Sciences and the next Mendeleev Congress.
K. S. Guzev
doaj  

The Role of the Decrees of Peter the Great in the Formation and Development of Russian Pharmacy. Part 2

open access: yesРазработка и регистрация лекарственных средств, 2023
The second part of the article presents the next steps of Peter the Great to improve the functioning of the pharmacy service in Russia. To improve the management of the nascent pharmacy service, the Emperor established the Main Pharmacy in the ...
K. S. Guzev
doaj  

Enhancement of Efficacy of Retinoids through Enhancing Retinoid-Induced RAR Activity and Inhibiting Hydroxylation of Retinoic Acid, and Its Clinical Efficacy on Photo-Aging

open access: yesPharmaceutics, 2022
Retinoids, one of the most robust bioactive materials, have been widely used to improve various dermatological and pathological conditions. The body has an endogenous mechanism that modulates the exogenous retinoid above physiological concentrations ...
Seongsu Kang   +4 more
doaj   +1 more source

Real Work Conditions of Pharmaceutic Servantsat the Beginning of the XX Century (Review)

open access: yesРазработка и регистрация лекарственных средств, 2019
Introduction. At the beginning of the twentieth century in the pharmaceutical community of Russia there were many problems. On the pages of the special press, such problems as the organization of pharmacy institutions (pharmacies, warehouses, shops ...
K. S. Guzev
doaj   +1 more source

Distinct Molten‐Globule Conformations in an Interacting Protein Domain Resolved by 19F NMR of Fluoroproline Residues

open access: yesAngewandte Chemie, EarlyView.
Modifying the conformational ensemble of “molten‐globule” protein by the site‐specific incorporation of stereoisomeric 4‐fluoroproline residues modulated its binding affinity and aggregation behavior. 19F NMR spectroscopy enabled the detection of key interactions responsible for structural and dynamic changes. ABSTRACT Recently, the application of deep
Abir Ben Bouzayene   +5 more
wiley   +2 more sources

Retinoids for prevention and treatment of actinic keratosis [PDF]

open access: yesAnais Brasileiros de Dermatologia, 2013
Actinic keratosis is a common cause of dermatological consultations and it presents a strong association with squamous cell carcinoma. Many substances are used for treatment and prevention, such as retinoids.
Mayra Ianhez   +3 more
doaj   +1 more source

Revival of the Russian chemical industry during the Soviet period (1917–1927). Part 4

open access: yesРазработка и регистрация лекарственных средств, 2023
This section contains appendices to the previous 4 parts of the article. These applications are important because they document every step taken by the leadership of the young Soviet Republic, and then the USSR, to restore the domestic chemical industry ...
K. S. Guzev
doaj  

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