Results 41 to 50 of about 27,382 (293)
Evaluation and comparison of natural and synthetic retinoids on model of neural development [PDF]
, 2008 Vitamin A and its derivatives, collectively termed retinoids, are a group of natural and synthetic molecules that are structurally and/or functionally analogous.
Buyers Christie, Victoria
core
Therapeutic applications of retinoids in ophthalmology [PDF]
, 1997 Vitamin A was used to treat night blindness by Egyptian physicians as early as 1500 BC. All compounds that exhibit pharmacological and physiological properties of the basic vitamin A alcohol moiety are nowadays referred to as retinoids.
Tabatabay, Cyrus A. +3 more
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Arthritis Care &Research, Accepted Article.Objectives We aimed to determine whether the short‐term response to biologics in biologic‐naïve psoriatic arthritis (PsA) is better in patients initiating biologic treatment early in the disease course. Methods PsA patients who started biologic therapy from the year 2000 to 2025 were included for analysis. Patients considered in the early treatment (ET)
Sung Min Cho +4 more
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YAKUGAKU ZASSHI, 1996 Retinoids, retinoic acid and its bioisosters, regulate many biological functions such as cell differentiation, proliferation and embryonic development in vertebrates, through binding to and activating their specific nuclear receptors. There are two classes of nuclear receptors for retinoids, retinoic acid receptors (RAR alpha, beta, gamma) and retinoid
H, Umemiya +4 more
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Retinoids: Novel Immunomodulators and tumor-suppressive agents? [PDF]
, 2012 Retinoids play important roles in the transcriptional activity of normal, degenerative and tumor cells. Retinoid analogues may be promising therapeutic agents for the treatment of immune disorders as different as type I diabetes and Systemic Lupus ...
MR Carratù +7 more
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Advanced Healthcare Materials, EarlyView.This study introduces a modular microfluidic platform that connects liver cells with live microbes to mimic key aspects of the gut–liver interaction in steatosis. Using this system, both microbial metabolites and live bacteria significantly reduced fat accumulation in liver cells, but live microbes triggered inflammation and broader metabolic changes ...
Hsih‐Yin Tan +7 more
wiley +1 more source
Retinoids in cancer therapy. [PDF]
, 1992 PURPOSE Recent reports of the dramatic antitumor effect of all-trans retinoic acid (RA) in patients with acute promyelocytic leukemia (APL) have generated renewed enthusiasm for clinical studies of retinoids for oncologic therapeutic indications. Here we
D R Parkinson +3 more
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Retinoids in hematology: a timely revival? [PDF]
, 2021 International audienceThe retinoic acid receptors (RARA, RARB, and RARG) are ligand-regulated nuclear receptors that act as transcriptional switches. These master genes drew significant interest in the 1990s because of their key roles in embryogenesis ...
Esnault, Cécile +2 more
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Advanced Science, EarlyView.Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu +10 more
wiley +1 more source
Vitamin A, endocrine tissues and hormones: interplay and interactions
Endocrine Connections, 2017 Vitamin A (retinol) is a micronutrient critical for cell proliferation and differentiation. In adults, vitamin A and metabolites such as retinoic acid (RA) play major roles in vision, immune and brain functions and tissue remodelling and metabolism. This
J Brossaud, V Pallet, J-B Corcuff
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