Results 61 to 70 of about 27,382 (293)

Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms

Molecular Cancer, 2010
Background Retinoids, through their cognate nuclear receptors, exert potent effects on cell growth, differentiation and apoptosis, and have significant promise for cancer therapy and chemoprevention.
Gronemeyer Hinrich, Aranda Ana, Jiménez-Lara Ana M   +2 more
doaj   +1 more source

Retinoids Delivery Systems in Cancer: Liposomal Fenretinide for Neuroectodermal-Derived Tumors

Pharmaceuticals, 2021
Retinoids are a class of natural and synthetic compounds derived from vitamin A. They are involved in several biological processes like embryogenesis, reproduction, vision, growth, inflammation, differentiation, proliferation, and apoptosis.
Veronica Bensa, Enzo Calarco, Elena Giusto, Patrizia Perri, Maria Valeria Corrias, Mirco Ponzoni, Chiara Brignole, Fabio Pastorino   +7 more
doaj   +1 more source

The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang, Lichong Shen, Junhui Zheng, Gisela Baur, Dilidaer Yasen, Honglin Zhu, Yi‐Nan Li, Xianyi Meng, Thuong Trinh‐Minh, Tim Filla, Debomita Chakraborty, Andrea‐Hermina Györfi, Christina Bergmann, Adam Reich, Alexander Kreuter, Georg Schett, Jörg H. W. Distler   +16 more
wiley   +1 more source

Retinoid nanoparticulates: Approachable gateway for acne treatment

Health Sciences Review, 2022
Acne vulgaris is a skin disorder that results due to clogging of hair follicles with dead skin cells and oils from the skin. Although acne is not a fatal disease, it has serious effects on the patients' physical and emotional states due to the fear of ...
Judy Lalrengpuii, Kaisar Raza, Awanish Mishra, Rahul Shukla   +3 more
doaj   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Retinoids: potential in cancer prevention and therapy [PDF]

, 2004
International audienceRetinoids (derivatives of vitamin A) are signalling molecules that play important roles in cell growth, differentiation and death.
Germain, Pierre, Altucci, Lucia, Clarke, Nicole, Gronemeyer, Hinrich   +3 more
core   +1 more source

Reducing Exposure Before Birth: An Interrupted Time Series Study of Prenatal Exposure to Fetotoxic Medications Under Risk Management Plans in Canada

Clinical Pharmacology &Therapeutics, EarlyView.
Canada's 2009 risk management plan (RMP) framework has not been evaluated for prenatal exposure impact. Conversely, widely used drugs such as nonsteroidal anti‐inflammatory drugs (NSAIDs) lack RMPs. We assessed first‐trimester exposure to RMP‐regulated medications following regulatory interventions and to NSAIDs following safety publications.
Nahiyan Saiyara Khan, Odile Sheehy, Lisiane Freitas Leal, Vanina Tchuente, Anick Bérard   +4 more
wiley   +1 more source

ABOUT GALEN (PAGES OF LIFE AND TRAITS OF THE PERSON IN THE ASSESSMENT OF THE DESCENDANTS)

Разработка и регистрация лекарственных средств, 2019
The paper presents the pages of life and some character traits of the Roman physician Galen. The source of information is the materials published in domestic and foreign literature.
K. S. Guzev
doaj  

Do topical retinoids cause acne to flare ? [PDF]

, 2009
BACKGROUND: Guidelines support this use of topical retinoids as a fundamental part of acne treatment regimens. However, existing dogma holds that topical retinoids may initially worsen acne.
McCalin, Richard, MD, Yentzer, Brad A, Feldman, Steven R   +2 more
core  

GALEN AND HIS KNOWLEDGE IN THE FIELD OF PHARMACOLOGY

Разработка и регистрация лекарственных средств, 2019
The paper presents the literature data on the knowledge K. Galen in pharmacology. The source of information is the materials published in domestic and foreign literature.
K. S. Guzev
doaj