Results 71 to 80 of about 31,233 (276)
Medicinal Research Reviews, EarlyView.ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley +1 more source
Retinoid-binding proteins: mediators of retinoid action [PDF]
Biochemical Journal, 2000 Active vitamin A metabolites, known as retinoids, are essential for multiple physiological processes, ranging from vision to embryonic development. These small hydrophobic compounds associate in vivo with soluble proteins that are present in a variety of cells and in particular extracellular compartments, and which bind different types of retinoids ...
openaire +2 more sources
PROTEOMICS, EarlyView.ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca +7 more
wiley +1 more source
50 Years of Topical Retinoids for Acne: Evolution of Treatment
, 2021 Since the US Food and Drug Administration (FDA) approved tretinoin in 1971, retinoids alone or combined with other agents have become the mainstay of acne treatment.
Callender, Valerie +5 more
core +2 more sources
The apothecary order – the origin and formation. Part 3
Разработка и регистрация лекарственных средствThe third part of the article is devoted to a review of sources reflecting the functions of the apothecary order. To these sources Historian scientists include: petitions, memories and releases (copies) from petitions, correspondence with regional ...
K. S. Guzev
doaj
Разработка и регистрация лекарственных средств, 2019 The paper presents literature data on the history of the finding of Ebers' papyrus and its further study. Its contents are disclosed: the diseases that were known to ancient doctors are listed, the list of medicines used by Egyptian doctors is presented,
K. S. Guzev
doaj
Neural Regeneration Research, 2019 All retinoids, which can be natural and synthetic, are chemically related to vitamin A. Both natural and synthetic retinoids use specific nuclear receptors such as retinoic acid receptors and retinoid X receptors to activate specific signaling pathways ...
Bhaskar C Das +2 more
doaj +1 more source
Synthetic retinoids as potential antitumour agents
, 2005 The retinoids, natural or synthetic derivatives of vitamin A, exhibit a variety of biological effects that may have implications in cancer chemoprevention and therapy.
F. Zunino +3 more
core +1 more source
Phytotherapy Research, EarlyView.Salvia miltiorrhiza Bunge in metabolic syndrome and cardiovascular diseases: multi‐target actions on shared signaling pathways. ABSTRACT Metabolic syndrome (MetS) represents a clinical disorder characterized by the clustering of conditions including obesity, elevated blood sugar levels, and high lipid levels, which are intricately linked to the onset ...
Zhiyi Jia +6 more
wiley +1 more source
ASSORTMENTS OF DRUGS AND TECHNOLOGICAL RECEIVES, WHICH THE FIRST DOCTORS APPLIED
Разработка и регистрация лекарственных средств, 2019 The paper presents information on how the Sumerians, doctors of Egypt, Ancient Greece and the Roman Empire treated their patients two thousand years or more ago. An attempt is made to analyze the assortments of medicines and technological methods used by
K. S. Guzev
doaj