Results 81 to 90 of about 77,321 (327)
N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential
iNew Medicine, EarlyView.ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen +6 more
wiley +1 more source
Разработка и регистрация лекарственных средств, 2019 The paper presents information about F.B. Schwabe and N. Zaklin, entrepreneurs of the late 19th and early 20th centuries who, through their labor and ingenuity, created the material and technical base that provided the development of various branches of ...
K. S. Guzev
doaj
Molecular Cancer, 2010 Background Retinoids, through their cognate nuclear receptors, exert potent effects on cell growth, differentiation and apoptosis, and have significant promise for cancer therapy and chemoprevention.
Gronemeyer Hinrich +2 more
doaj +1 more source
Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function [PDF]
, 2018 Visual function in vertebrates critically depends on the continuous regeneration of visual pigments in rod and cone photoreceptors. RPE65 is a well-established retinoid isomerase in the pigment epithelium that regenerates rhodopsin during the rod visual ...
Angueyra, Juan M +11 more
core +1 more source
ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion [PDF]
, 2016 Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a dismal survival rate. Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homoeostasis of the tumour microenvironment to favour cancer ...
Attwood, S +10 more
core +2 more sources
Journal of Ultrasound in Medicine, EarlyView.Suppurative nevus comedonicus (SNC) is a variant of nevus comedonicus in which the characteristic features coexist with recurrent inflammatory lesions that clinically resemble those of hidradenitis suppurativa (HS). We present the ultrasound characteristics of this entity and emphasize the value of high‐resolution dermatologic ultrasound both as a ...
Marta Ivars +4 more
wiley +1 more source
Kidney regeneration: common themes from the embryo to the adult [PDF]
, 2013 The vertebrate kidney has an inherent ability to regenerate following acute damage. Successful regeneration of the injured kidney requires the rapid replacement of damaged tubular epithelial cells and reconstitution of normal tubular function ...
Cirio, Maria Cecilia +4 more
core +1 more source
JEADV Clinical Practice, EarlyView.Hidradenitis suppurativa (HS) is often diagnosed late, complicating management. In this nationwide Danish study including 10,196 patients with dermatologist‐verified HS, we examined treatment patterns before and after referral to specialised hospital care.
Nana A. L. Rosenø +8 more
wiley +1 more source
Novel tretinoin 0.05% lotion for the once-daily treatment of moderate-to-severe acne vulgaris in a preadolescent population. [PDF]
, 2019 BackgroundAcne vulgaris (acne) is a common skin condition in children and adolescents. Efficacy of tretinoin is well documented in studies that included pediatric patients (12-18 years of age). With acne routinely presenting in younger patients, data are
Bhatt, Varsha +4 more
core +1 more source
The retina visual cycle is driven by cis retinol oxidation in the outer segments of cones [PDF]
, 2017 Vertebrate rod and cone photoreceptors require continuous supply of chromophore for regenerating their visual pigments after photoactivation. Cones, which mediate our daytime vision, demand a particularly rapid supply of 11-cis retinal chromophore in ...
Cornwall, M. Carter +3 more
core +2 more sources