Results 51 to 60 of about 27,382 (293)

Therapeutic insights elaborating the potential of retinoids in Alzheimer’s disease

open access: yesFrontiers in Pharmacology, 2022
Alzheimer’s disease (AD) is perceived with various pathophysiological characteristics such oxidative stress, senile plaques, neuroinflammation, altered neurotransmission immunological changes, neurodegenerative pathways, and age-linked alterations.
Tapan Behl   +11 more
doaj   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

open access: yesAdvanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu   +12 more
wiley   +1 more source

Sythesis of retinoic acid analogues & investigations into their ability to induce stem cell differentation [PDF]

open access: yes, 2009
Human embryogenesis and ensuing adult homeostasis are directed by the complex interplay of a wide range of exquisitely controlled signalling molecules and pathways. All-trans-retinoic acid (ATRA) is one such important hormone-like compound that regulates
Bridgens, Caroline Emma
core  

RETINOIDS IN DERMATOLOGY:FUNCTIONAL ACTIVITY AND PROSPECTS OF SYNTHETIC ANALOGUES

open access: yesBiotechnologia Acta, 2020
The aim of the work was to analyze and summarize information on the functional activity of known retinoids, as well as to determine the directions of their modification and prospects for the use of their synthetic analogues in dermatology.
V. B. KOVTUN
doaj   +1 more source

Degradation Mechanisms, Encapsulation‐Based Stabilization, and Analytical Detection of Vitamin A

open access: yesJournal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Vitamin A is an important lipid‐soluble micronutrient essential for vision, immune function, and overall growth and development. However, vitamin A is unstable and susceptible to environmental factors because of its conjugated structure and inherent chemical reactivity.
Latheesha Abeywardana   +5 more
wiley   +1 more source

Retinoids [PDF]

open access: yes, 2018
Retinoids are structural and functional analogues of vitamin A that exert multiple effects on cellular differentiation and proliferation, the immune system, and embryonic development Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are ...
Sorg, Olivier, Saurat, Jean-Hilaire
core  

Modulation of Differentiation by Retinoids [PDF]

open access: yes, 1983
At high levels of vitamin A and other retinoids (3 × 10-6 M) attachment of human keratinocytes to 3T3-coated plastic dishes is mildly inhibited, Retinoids at this concentration in culture media seem to have an antikeratinizing effect in that cells appear
Kubilus, Joseph
core   +1 more source

Retinoids in Fungal Infections: From Bench to Bedside

open access: yesPharmaceuticals, 2021
Retinoids—a class of chemical compounds derived from vitamin A or chemically related to it—are used especially in dermatology, oncohematology and infectious diseases.
Terenzio Cosio   +7 more
doaj   +1 more source

Dual Functions of Dietary Rubber Seed Oil Supplementation: Enriching N‐3 Polyunsaturated Fatty Acids and Enhancing Antioxidant Capacity in Pekin Ducks

open access: yesAnimal Research and One Health, EarlyView.
Dietary RSO supplementation improved growth performance, simultaneously enriched n‐3 polyunsaturated fatty acids (n‐3 PUFA), and enhanced antioxidant capacity in Pekin ducks, which suggested that RSO has the potential to be a novel n‐3 PUFA source and an antioxidant for Pekin ducks to generate animal functional foods.
Lei Zhuang   +10 more
wiley   +1 more source

Binding of retinoids to uteroglobin [PDF]

open access: yes, 1994
Uteroglobin, a progesterone-binding secretory protein, was shown to bind retinoic acid and retinol in a non-saturable manner, at least up to concentrations of retinoids of 20 μM.
Martinez, M.Pérez   +7 more
core   +1 more source

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