Results 11 to 20 of about 16,020 (245)
Genome editing with retroelements [PDF]
Science, 2023 RNA-guided DNA writing enzymes offer promise for programmable gene ...
Stephen Tang, Samuel H. Sternberg
openalex +3 more sources
Diversity-Generating Retroelements in Prokaryotic Immunity [PDF]
International Journal of Molecular Sciences, 2023 AbstractAdaptive immunity systems found in different organisms fall into two major types. Prokaryotes possess CRISPR-Cas systems, recognizing former invaders using the memorized (captured) pieces of their DNA as the pathogen signatures. Mammals possess a vast repertory of antibodies and T-cell receptors variants generated in advance.
Ilya S. Belalov +2 more
openalex +3 more sources
Astronauts as a Human Aging Model: Epigenetic Age Responses to Space Exposure. [PDF]
Aging CellThis longitudinal analysis of Axiom‐2 astronauts reveals that spaceflight induces a rapid andsignificant epigenetic age acceleration that is largely reversible upon return to Earth. These findings identify space exposure as a unique model for studying aging mechanisms and potentially testing geroprotective interventions.
Fuentealba M +6 more
europepmc +2 more sources
Methylation of LINE-1 Retroelement in People with Type 1 Diabetes. [PDF]
Genes (Basel)Katsanou A +5 more
europepmc +3 more sources
Prospects for the use of statins in antiviral therapy [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2023 Inhibitors of hydroxymethylglutaryl-CoA reductase, in addition to suppressing cholesterol synthesis, have an antiviral effect. Clinical studies have shown antiviral efficacy of statins against COVID-19, HCV, HBV, RSV, HIV, influenza viruses.
Mustafin R.N.
doaj +1 more source
Involvement of retroelements in the autoimmune response in humans
Exploration of Medicine, 2022 Retroelements are mobile genomic components requiring an RNA intermediate which is reverse-transcribed into complementary DNA for transposition. Human genome contains a vast amount of retroelements including retrotransposons and endogenous retroviruses ...
Sezer Okay
doaj +1 more source
Large-scale transcriptome analysis of retroelements in the migratory locust, Locusta migratoria. [PDF]
PLoS ONE, 2012 BackgroundRetroelements can successfully colonize eukaryotic genome through RNA-mediated transposition, and are considered to be some of the major mediators of genome size.
Feng Jiang +4 more
doaj +1 more source
Role of retroelements in the development of COVID-19 neurological consequences
Russian Open Medical Journal, 2022 Retroelements play a key role in brain functioning in humans and other animals, since they represent dynamic regulatory elements controlling the expression of specific neuron types.
Rustam N. Mustafin +3 more
doaj +1 more source
Genome Research, 2002 The eukaryotic genome has undergone a series of epidemics of amplification of mobile elements that have resulted in most eukaryotic genomes containing much more of this ‘junk’ DNA than actual coding DNA. The majority of these elements utilize an RNA intermediate and are termed retroelements. Most of these retroelements appear to amplify in evolutionary
Prescott L, Deininger, Mark A, Batzer
openaire +2 more sources
Diversity-generating retroelements [PDF]
Current Opinion in Microbiology, 2007 Parasite adaptation to dynamic host characteristics is a recurrent theme in biology. Diversity-generating retroelements (DGRs) are a newly discovered family of genetic elements that function to diversify DNA sequences and the proteins they encode. The prototype DGR was identified in a temperate bacteriophage, BPP-1, on the basis of its ability to ...
Bob, Medhekar, Jeff F, Miller
openaire +2 more sources