Contrasting distributions and expression characteristics of transcribing repeats in Setaria viridis [PDF]
The Plant Genome, Volume 18, Issue 1, March 2025.Abstract Repetitive DNA contributes significantly to plant genome size, adaptation, and evolution. However, little is understood about the transcription of repeats. This is addressed here in the plant green foxtail millet (Setaria viridis). First, we used RepeatExplorer2 to calculate the genome proportion (GP) of all repeat types and compared the GP of
Ana Luiza Franco +5 more
wiley +3 more sources
Eco-evolutionary significance of domesticated retroelements in microbial genomes [PDF]
Mobile DNA, 2022 Since the first discovery of reverse transcriptase in bacteria, and later in archaea, bacterial and archaeal retroelements have been defined by their common enzyme that coordinates diverse functions.
Blair G. Paul, A. Murat Eren
doaj +2 more sources
LTR retroelements in the genome of
BMC Genomics, 2010 Background Long terminal repeat (LTR) retroelements represent a successful group of transposable elements (TEs) that have played an important role in shaping the structure of many eukaryotic genomes.
Kim Sun +5 more
doaj +4 more sources
SERpredict: Detection of tissue- or tumor-specific isoforms generated through exonization of transposable elements [PDF]
BMC Genetics 2007 8:78, 2008 Background: Transposed elements (TEs) are known to affect transcriptomes, because either new exons are generated from intronic transposed elements (this is called exonization), or the element inserts into the exon, leading to a new transcript. Several examples in the literature show that isoforms generated by an exonization are specific to a certain ...
Ast, Gil +4 more
arxiv +6 more sources
Does selection against transcriptional interference shape retroelement-free regions in mammalian genomes? [PDF]
PLoS ONE, 2008 BACKGROUND: Eukaryotic genomes are scattered with retroelements that proliferate through retrotransposition. Although retroelements make up around 40 percent of the human genome, large regions are found to be completely devoid of retroelements.
Tobias Mourier, Eske Willerslev
doaj +5 more sources
The role of retroelements in Parkinson's disease development. [PDF]
Vavilovskii Zhurnal Genet SelektsiiParkinson’s disease is the second most common neurodegenerative disease characterized by accumulation of alpha-synuclein and Lewy bodies in the brain’s substantia nigra.
Mustafin RN.
europepmc +2 more sources
Retroelements versus APOBEC3 family members: No great escape from the magnificent seven [PDF]
Frontiers in Microbiology, 2012 Retroelements comprise a large and successful family of transposable genetic elements that, through intensive infiltration, have shaped the genomes of humans and other mammals over millions of years.
Juan F Arias +3 more
doaj +2 more sources
Expression of the <i>Nicotiana benthamiana</i> Retrozyme 1 (NbRZ1) Genomic Locus. [PDF]
Plants (Basel)Retrozymes are a class of non-autonomous plant retrotransposons that have long terminal repeats (LTRs) containing hammerhead ribozymes (HHRs) that facilitate the circularization of the retrozyme RNA.
Lezzhov AA +4 more
europepmc +2 more sources
Endogenous retroelements in hematological malignancies: From epigenetic dysregulation to therapeutic targeting [PDF]
American Journal of Hematology, Volume 100, Issue 1, Page 116-130, January 2025.ERE dysregulation in hematological malignancies leads to cellular and immunological consequences presenting therapeutic opportunities. Harnessing EREs with epigenetic drugs and immunotherapies advances precision hematology. Abstract Endogenous retroelements (EREs), which comprise half of the human genome, play a pivotal role in genome dynamics.
Mohamed Chour +3 more
wiley +2 more sources
Prospects for breast cancer immunotherapy using microRNAs and transposable elements as objects. [PDF]
Explor Target Antitumor TherOne of the directions in treatment of chemoresistant breast cancer (BC) may include new methods of activating the immune response against tumor cells. Clinically used checkpoint inhibition using antibodies to PD-1 and PD-L1 works in some patients, but ...
Mustafin RN.
europepmc +2 more sources