Results 71 to 80 of about 16,020 (245)

Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions

Aging Cell, Volume 25, Issue 2, February 2026.
Hematopoietic aging arises from intrinsic stem‐cell decline and bone‐marrow niche dysfunction, leading to myeloid skewing, immunosenescence, and clonal hematopoiesis. These changes drive systemic inflammation and multi‐organ disease, which in turn further disrupt the bone‐marrow niche and hematopoietic stem cell (HSC) function, creating a vicious cycle
Masashi Miyawaki, Seiji Hashimoto, Sumito Ogawa, Yoshitaka Kase   +3 more
wiley   +1 more source

LTR retrotransposon dynamics in the evolution of the olive (Olea europaea) genome. [PDF]

, 2014
Improved knowledge of genome composition, especially of its repetitive component, generates important information for both theoretical and applied research.
A. Cavallini, Ammiraju, Baucom, Beguiristain, Buti, Cavallini, E. Barghini, F. Cattonaro, H.  imkova, Huang, J. Dole el, J. Vrana, Jaillon, Jiao, Jurka, Katsiotis, Kumar, L. Natali, Le Rouzic, Lorite, M. Morgante, Ming, Morse, Nei, Paterson, R. M. Cossu, Rozas, S. Scalabrin, SanMiguel, Sarri, Schnable, Sonnhammer, Stergiou, T. Giordani, Ungerer, Venner, Vukich   +36 more
core   +1 more source

Cell Line Fingerprinting Using Retroelement Insertion Polymorphism [PDF]

BioTechniques, 2005
Human cell lines are an indispensable tool for functional studies of living entities in their numerous manifestations starting with integral complex systems such as signal pathways and networks, regulation of gene ensembles, epigenetic factors, and finishing with pathological changes and impact of artificially introduced elements, such as various ...
Svetlana V. Ustyugova, Anna L. Amosova, Yuri B. Lebedev, Eugene D. Sverdlov   +3 more
openaire   +3 more sources

Alu Overexpression Leads to an Increased Double‐Stranded RNA Signature in Dermatomyositis

Arthritis &Rheumatology, Volume 78, Issue 1, Page 209-222, January 2026.
Objective Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because coding sequences constitute <1.2% of our genomes, there is a need to explore the role of the noncoding genome in disease pathogenesis.
Rayan Najjar, Andrew Mammen, Tomas Mustelin   +2 more
wiley   +1 more source

The Method of Viral Mimicry in Oncology and Prospects for its Improvement

Архивъ внутренней медицины, 2023
Malignant neoplasms cells are characterized by clonal evolution that is resistant to the applied antitumor drug and evasion from the effects of the immune system.
R. N. Mustafin
doaj   +1 more source

CARE1, a TY3-gypsy long terminal repeat retrotransposon in the food legume chickpea (Cicer arietinum L) [PDF]

, 2007
We report a novel Ty3-gypsy long terminal repeat retrotransposon CARE1 (_Cicer arietinum_ retro-element 1) in chickpea. This 5920-bp AT-rich (63%) element carries 723-bp 5' and 897-bp 3' LTRs respectively flanking an internal region of 4300-bp.
Kailash C. Upadhyaya, Manoj D. R. Rajput
core   +1 more source

Genome Sequence of the Chestnut Blight Fungus Cryphonectria parasitica EP155: A Fundamental Resource for an Archetypical Invasive Plant Pathogen. [PDF]

, 2020
Cryphonectria parasitica is the causal agent of chestnut blight, a fungal disease that almost entirely eliminated mature American chestnut from North America over a 50-year period. Here, we formally report the genome of C. parasitica EP155 using a Sanger
Aerts, Andrea, Barry, Kerrie, Churchill, Alice CL, Crouch, Jo Anne, Dawe, Angus, Grigoriev, Igor V, Grimwood, Jane, Hillman, Bradley I, Milgroom, Michael G, Nuss, Donald L, Pangilinan, Jasmyn, Salamov, Asaf, Schmutz, Jeremy, Smith, Myron, Yadav, Jagjit S   +14 more
core  

Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome. [PDF]

, 2015
Aicardi-Goutières syndrome (AGS) is a severe childhood inflammatory disorder that shows clinical and genetic overlap with systemic lupus erythematosus (SLE).
Chédin, Frédéric, Hartono, Stella R, Lim, Yoong Wearn, Sanz, Lionel A, Xu, Xiaoqin   +4 more
core   +2 more sources

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, Volume 19, Issue 12, Page 3750-3768, December 2025.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Prospects for breast cancer immunotherapy using microRNAs and transposable elements as objects

Exploration of Targeted Anti-tumor Therapy
One of the directions in treatment of chemoresistant breast cancer (BC) may include new methods of activating the immune response against tumor cells. Clinically used checkpoint inhibition using antibodies to PD-1 and PD-L1 works in some patients, but ...
Rustam Nailevich Mustafin
doaj   +1 more source