Results 71 to 80 of about 14,990 (203)
Frontiers in NeuroscienceTetrapod endogenous retroelements (ERE) encode proteins that have been exapted to perform many roles in development and also in innate immunity, including GAG (group specific antigen) proteins from the ERE long terminal repeat (LTR) family, some of which
Alan Herbert
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Relationship of MicroRNAs with Transposable Elements in the Type 1 Diabetes Development
Архивъ внутренней медициныThe review article describes the involvement of epigenetic factors in type 1 diabetes mellitus (T1DM) etiopathogenesis. The disease is characterized by changes in expression of microRNAs that affect the transcription of genes involved in autoimmune ...
R. N. Mustafin
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Targeting SETDB1 in cancer and immune regulation: Potential therapeutic strategies in cancer
The Kaohsiung Journal of Medical Sciences, Volume 41, Issue 3, March 2025.Abstract SET domain bifurcated histone lysine methyltransferase 1 (SETDB1/ESET), a pivotal H3K9 methyltransferase, has been extensively studied since its discovery over two decades ago. SETDB1 plays critical roles in immune regulation, including B cell maturation, T‐cell activity modulation, and endogenous retrovirus (ERV) silencing.
Bo‐Syong Pan +3 more
wiley +1 more source
Role of MicroRNAs and Retroelements in the Pathogenesis of Atherosclerosis
Архивъ внутренней медициныAtherosclerosis is the leading cause of cardiovascular disease among adults. The incidence of atherosclerosis increases significantly with age, which indicates the possible influence of aging mechanisms on the development of the disease, including ...
R. N. Mustafin, E. A. Galieva
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The 5'-end transitional CpGs between the CpG islands and retroelements are hypomethylated in association with loss of heterozygosity in gastric cancers [PDF]
, 2006 BACKGROUND: A loss of heterozygosity (LOH) represents a unilateral chromosomal loss that reduces the dose of highly repetitive Alu, L1, and LTR retroelements.
Eun-Joo Seo +6 more
core +2 more sources
Genome and Tissue‐Specific Transcriptome of the Tropical Milkweed (Asclepias curassavica)
Plant Direct, Volume 9, Issue 3, March 2025.ABSTRACT Tropical milkweed (Asclepias curassavica) serves as a host plant for monarch butterflies (Danaus plexippus) and other insect herbivores that can tolerate the abundant cardiac glycosides that are characteristic of this species. Cardiac glycosides, along with additional specialized metabolites, also contribute to the ethnobotanical uses of A ...
Honglin Feng +9 more
wiley +1 more source
An annotated list of bivalent chromatin regions in human ES cells: a new tool for cancer epigenetic research [PDF]
Oncotarget, Impact journals, 2017, 8, pp.4110 - 4124, 2018 CpG islands (CGI) marked by bivalent chromatin in stem cells are believed to be more prone to aberrant DNA methylation in tumor cells. The robustness and genome-wide extent of this instructive program in different cancer types remain to be determined.
arxiv
Aging Cell, Volume 24, Issue 2, February 2025.The combination of FTO knockdown and METTL16 overexpression synergistically increased m6A levels, subsequently downregulating the expression of the H3K9me3 methyltransferase SUV39H1. This resulted in a reduction of H3K9me3 levels and the activation of the ERV1 family, notably LTR7 and LTR12.
Xiujuan Hu +8 more
wiley +1 more source
Participation of retroelements in chromoanagenesis in cancer development
Сибирский онкологический журналPurpose of the study: to determine the role of retroelements in chromoanagenesis mechanisms in cancer etiopathogenesis.Material and Methods. The search for relevant sources was carried out in the Scopus, Web of Science, PubMed, Elibrary systems ...
R. N. Mustafin
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Contribution of Mobile Group II Introns to Sinorhizobium meliloti Genome Evolution
Frontiers in Microbiology, 2018 Mobile group II introns are ribozymes and retroelements that probably originate from bacteria. Sinorhizobium meliloti, the nitrogen-fixing endosymbiont of legumes of genus Medicago, harbors a large number of these retroelements.
Nicolás Toro +4 more
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