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Molecular biology of retroelements
Virus Genes, 1990The observations presented on the molecular biology primarily of viral retroelements illustrate the complexity of the replication and expression of these molecules. They are revealing the subtle and intricate mechanisms by which these molecules bypass the constraints of the normal cellular machinery.
H, Will, R, Hull
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Rex Retroelements and Teleost Genomes: An Overview [PDF]
International Journal of Molecular Sciences, 2018 Repetitive DNA is an intriguing portion of the genome still not completely discovered and shows a high variability in terms of sequence, genomic organization, and evolutionary mode. On the basis of the genomic organization, it includes satellite DNAs, which are organized as long arrays of head-to-tail linked repeats, and transposable elements, which ...
Adriana Canapa +2 more
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Retroelements in human disease
Gene, 2013Retroelements are an abundant class of noncoding DNAs present in about half of the human genome. Among them, L1, Alu and SVA are currently active. They "jump" by retrotransposition, shuffle genomic regions by 5' and 3' transduction, and promote or inhibit gene transcription by providing alternative promoters or generating antisense and/or regulatory ...
Kristel, Kaer, Mart, Speek
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Retroelements in higher plants
Trends in Genetics, 1992Representatives of several classes of retroelements have been characterized in a broad range of plant species, where they appear at variable and sometimes very high copy numbers. So far, only a very small number of plant elements have been shown to be active, and this activity seems to be restricted to specific situations of 'genomic shock'.
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Retroelements in Genome Organization
Science, 1996Transposons, mobile pieces of DNA, were first described in maize by B. McClintock. Now maize yields another surprise, as shown by SanMiguel et al . ( p. 765 ) in this week's issue. One particular class of transposon, retrotransposons, is present in the maize genome in numbers so vast that it ...
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Retroelements and their impact on genome evolution and functioning
Cellular and Molecular Life Sciences, 2009Retroelements comprise a considerable fraction of eukaryotic genomes. Since their initial discovery by Barbara McClintock in maize DNA, retroelements have been found in genomes of almost all organisms. First considered as a "junk DNA" or genomic parasites, they were shown to influence genome functioning and to promote genetic innovations.
Anton Buzdin +2 more
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Hitching a ride with a retroelement
Science, 2021RNA Delivery Retroviruses and retroelements have inserted their genetic code into mammalian genomes throughout evolution. Although many of these integrated virus-like sequences pose a threat to genomic integrity, some have been retooled by mammalian cells to perform essential roles in development. Segel et al.
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Science, 2004
Molecular biologists have long been intrigued by mobile DNA elements in the genome called retrotransposons and how they replicate and become inserted at new chromosomal sites. New insights into how branching and debranching of retrotransposon transcripts may contribute to this process (Cheng and Menees) are discussed by Perlman and Boeke in ...
Philip S. Perlman, Jef D. Boeke
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Molecular biologists have long been intrigued by mobile DNA elements in the genome called retrotransposons and how they replicate and become inserted at new chromosomal sites. New insights into how branching and debranching of retrotransposon transcripts may contribute to this process (Cheng and Menees) are discussed by Perlman and Boeke in ...
Philip S. Perlman, Jef D. Boeke
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Evolution and biological significance of human retroelements
Virus Genes, 1995Retroelements comprise a substantial portion of the human genome. Their large number and ubiquitous distribution has led scientists to speculate about their evolutionary origin and their biological functions. Human endogenous retroviruses and their retrotransposon relatives represent a reservoir of possibly pathogenic retroviral genes that may be ...
C, Leib-Mösch, W, Seifarth
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Retroelements and formation of chimeric retrogenes
Cellular and Molecular Life Sciences, 2004It is very likely that formation of new genes is the main pathway of molecular evolution in living organisms. Many such genes are products of preexisting reshuffling of genetic material. In these processes a very important role is played by mutations associated with the activity of transposable elements, mostly retroelements (REs) for higher eukaryotes.
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