Results 61 to 70 of about 474 (133)

The Evolving Landscape of Clinical Aging Clocks: From Epigenetic to Multi‐Omics Integration

Aging Cell, Volume 25, Issue 6, June 2026.
Multi‐omics aging clocks capture biological heterogeneity beyond single‐omics models, improving risk stratification. Key challenges include unknown biological meaning, timescale mismatches, and validation gaps. Future clocks must distinguish pathological damage from adaptive remodeling—damage accumulation is the most actionable target for anti‐aging ...
Liying Liu, Yuanyuan Lai, Chunhui Tian, Yufei Huang, Jianheng Hao, Yuemeng Zhao, Dan Chen, Tianyu Wu, Daqian Zhou, Xiaoyan Zheng, Han Yang, Zheng Yu, Nihong Li, Jie Yang   +13 more
wiley   +1 more source

The APOBEC3 Family of Retroelement Restriction Factors [PDF]

, 2013
The ability to regulate and even target mutagenesis is an extremely valuable cellular asset. Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by vertebrates to promote antibody diversity and defend against foreign nucleic acids.
Eric W, Refsland, Reuben S, Harris
openaire   +2 more sources

Participation of retroelements in chromoanagenesis in cancer development

Сибирский онкологический журнал
Purpose of the study: to determine the role of retroelements in chromoanagenesis mechanisms in cancer etiopathogenesis.Material and Methods. The search for relevant sources was carried out in the Scopus, Web of Science, PubMed, Elibrary systems ...
R. N. Mustafin
doaj   +1 more source

Macrophage piezo1 senses mechanical force to drive osteoclastogenesis via ZBP1: Implications for bone remodelling therapy

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
In the periodontal microenvironment, orthodontic mechanical force activates the mechanosensitive ion channel Piezo1 on macrophages, triggering Ca2+ influx. The increased intracellular Ca2+ concentration drives the upregulation and activation of the innate immune sensor ZBP1, promoting the formation of Z‐NA.
Linlin Zhu, Kejia Zhang, An Song, Weiye Zhao, Yongze Lin, Hao Xu, Zhichun Jin, Yan Wang, Shengnan Wu, Xueyu Sun, Heng Gu, Ming Lu, Hanwen Zhang, Bin Yan   +13 more
wiley   +1 more source

Stage‐Specific RNA Turnover Drives Small RNA Dynamics in Arabidopsis–Colletotrichum Interactions

Plant Direct, Volume 10, Issue 5, May 2026.
ABSTRACT Small RNAs (sRNAs) are key regulators of plant defense and have been implicated in cross‐kingdom interactions with pathogens. The hemibiotrophic fungus Colletotrichum higginsianum infects Arabidopsis thaliana through three stages: appressorial penetration, biotrophy, and necrotrophy.
Carolina E. Armijos, Thi‐Thu‐Huyen Chu, Richard J. O' Connell, Blake C. Meyers, Patricia Baldrich   +4 more
wiley   +1 more source

Tenofovir, Interferon Pathways, and Mucosal Immunity: Implications for People Living With HIV

American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.
ABSTRACT Background Antiretroviral therapy (ART) suppresses HIV replication and protects people living with HIV (PLWH) from progressing to AIDS. However, despite ART, many PLWH experience chronic immune activation, which contributes to premature aging and non‐AIDS‐related comorbidities. One reason for this chronic immune activation (CIA) is HIV and its
Florian Hladik, Sean M. Hughes, Claire N. Levy, Rachel L. Creighton, Romel Mackelprang, Germán G. Gornalusse   +5 more
wiley   +1 more source

GmSNAP14: a key contributor to soybean cyst nematode resistance in soybean

New Phytologist, Volume 250, Issue 4, Page 2477-2494, May 2026.
Summary Soybean (Glycine max) plants counteract soybean cyst nematode (SCN, Heterodera glycines Ichinohe) infection through an impairment of soluble N‐ethylmaleimide‐sensitive factor (NSF) attachment protein (α‐SNAP) – NSF interactions and vesicular trafficking leading to cellular toxicity in response to nematode feeding.
Vinavi A. Gamage, Mariola Usovsky, Anser Mahmood, Elizabeth De Meyer, Bishnu Dhital, Clinton G. Meinhardt, Qijian Song, Lesa J. Beamer, Andrew M. Scaboo, Melissa G. Mitchum   +9 more
wiley   +1 more source

Neurodegenerative diseases reflect the reciprocal roles played by retroelements in regulating memory and immunity

Frontiers in Neuroscience
Tetrapod endogenous retroelements (ERE) encode proteins that have been exapted to perform many roles in development and also in innate immunity, including GAG (group specific antigen) proteins from the ERE long terminal repeat (LTR) family, some of which
Alan Herbert
doaj   +1 more source

Relationship of MicroRNAs with Transposable Elements in the Type 1 Diabetes Development

Архивъ внутренней медицины
The review article describes the involvement of epigenetic factors in type 1 diabetes mellitus (T1DM) etiopathogenesis. The disease is characterized by changes in expression of microRNAs that affect the transcription of genes involved in autoimmune ...
R. N. Mustafin
doaj   +1 more source

CDT retroelement [PDF]

Plant Signaling & Behavior, 2008
The resurrection plant Craterostigma plantagineum can tolerate up to 96% loss of its water content and recover from such extreme dehydration within several hours. This property is not shared by callus which has a strict requirement for exogenous abscissic acid (ABA) to survive severe water loss.
openaire   +3 more sources