Results 51 to 60 of about 474 (133)

Genome Assemblies for Seven Families of Birds From the Global South

Molecular Ecology Resources, Volume 26, Issue 5, July 2026.
ABSTRACT Tropical regions are biodiversity‐rich, yet remain underrepresented in the availability of genomic resources, as is evident in the Western Ghats of India, a biodiversity hotspot with high endemism. Here, we present high‐quality, de novo genome assemblies for seven birds, representing seven families distributed in the Western Ghats: Black‐naped
K. L. Vinay, Naman Goyal, Ashwin Warudkar, Chiti Arvind, V. V. Robin   +4 more
wiley   +1 more source

Prospects for breast cancer immunotherapy using microRNAs and transposable elements as objects

Exploration of Targeted Anti-tumor Therapy
One of the directions in treatment of chemoresistant breast cancer (BC) may include new methods of activating the immune response against tumor cells. Clinically used checkpoint inhibition using antibodies to PD-1 and PD-L1 works in some patients, but ...
Rustam Nailevich Mustafin
doaj   +1 more source

Unconventional Protein Secretion in the Central Nervous System: Mechanisms and Roles in Physiology and Disease

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Neurons and glia secrete and respond to numerous proteins that are released independently of the conventional ER–Golgi pathway. These unconventionally secreted proteins exert diverse pathogenic, immunomodulatory, and neuroprotective functions and are therefore implicated in multiple neurodegenerative diseases. They originate in the cytosol and exit the
Steven A. Krauklis, Sevnur Kömürlü Keçeli, Edward M. Campbell, Prabhodh S. Abbineni   +3 more
wiley   +1 more source

An autoimmune disease prevented by anti-retroviral drugs

Retrovirology, 2011
Background Both Aicardi-Goutières syndrome, a Mendelian mimic of congenital infection, and the autoimmune disease systemic lupus erythematosus can result from mutations in the gene encoding the enzyme Trex1.
Beck-Engeser Gabriele B, Eilat Dan, Wabl Matthias   +2 more
doaj   +1 more source

Ontogenetic Sequence of Differential Gene Expression in Predator‐Induced Daphnia pulex

Molecular Ecology, Volume 35, Issue 13, July 2026.
ABSTRACT In response to predators, many Daphnia species develop inducible morphological defenses. These traits are phenotypically plastic, meaning their production is suppressed in the absence of the predator. While previous studies have identified several neurohumoral factors and candidate genes involved in the development of the defenses, the ...
Andrey Rozenberg, Linda C. Weiss, Tatjana Schwarz, Nancy Kühne, Uwe John, Ralph Tollrian   +5 more
wiley   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, Volume 9, Issue 6, Page 1167-1179, June 2026.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

The Protein Phosphatase Inhibitor LB100 Targets the Mesenchymal Lineage of Pancreatic Ductal Adenocarcinoma

MedComm, Volume 7, Issue 6, June 2026.
To define the mechanisms of sensitivity to PP2A inhibitors (PP2Ai), we combined molecular profiling of PP2Ai responses with genome‐wide genetic screens. PP2Ai preferentially target mesenchymal pancreatic ductal adenocarcinoma (PDAC) cells and engage pathways linked to transcriptional elongation, splicing, metabolism, and ER stress response factors ...
Janine Murr, Carolin Schneider, Ningjun Duan, Hazal Köse, Anantharamanan Rajamani, Xueyang He, Jonas Buchloh, Christian Hintze, Atharva Naik, Daniel Goeke, Nicole Rjasanow, Lukas Krauß, Alexandra Nguyen, Sebastian A. Widholz, Christian Schneeweis, Riccardo Trozzo, Felix Orben, Sebastian Mueller, Rupert Öllinger, Juan J Montero, Michael Dudek, Percy Knolle, Bo Kong, Volker Ellenrieder, Constanza Tapia Contreras, Elisabeth Hessmann, Marian Grade, Michael Ghadimi, Christian J. Braun, Roland Rad, Maximillian Reichert, Ulrich Keller, Roland M. Schmid, Paul L. Boutz, Dieter Saur, Matthias Wirth, Oliver H. Krämer, Günter Schneider   +37 more
wiley   +1 more source

Role of MicroRNAs and Retroelements in the Pathogenesis of Atherosclerosis

Архивъ внутренней медицины
Atherosclerosis is the leading cause of cardiovascular disease among adults. The incidence of atherosclerosis increases significantly with age, which indicates the possible influence of aging mechanisms on the development of the disease, including ...
R. N. Mustafin, E. A. Galieva
doaj   +1 more source

A chromosome‐level genome assembly of Solanum brevicaule (PI 473011) Y1‐5, a wild potato relative with robust resistance to potato cyst nematodes

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Potato cyst nematodes (PCNs), Globodera rostochiensis and Globodera pallida, are globally recognized quarantine pests that can cause severe yield losses in potatoes (Solanum tuberosum L.) if left uncontrolled. Deploying host resistance remains the most effective, economical, and environmentally sustainable strategy for PCN control.
Senthilkumar Shanmugavel, Shengwei Hu, Huijun Yang, Shiyan Chen, John Bamberg, Dongyan Zhao, Bhoja R. Basnet, Craig T. Beil, Moira Sheehan, Vidyasagar Sathuvalli, Xiaohong Wang   +10 more
wiley   +1 more source

Exceptional diversity, non-random distribution, and rapid evolution of retroelements in the B73 maize genome. [PDF]

PLoS Genetics, 2009
Recent comprehensive sequence analysis of the maize genome now permits detailed discovery and description of all transposable elements (TEs) in this complex nuclear environment.
Regina S Baucom, James C Estill, Cristian Chaparro, Naadira Upshaw, Ansuya Jogi, Jean-Marc Deragon, Richard P Westerman, Phillip J Sanmiguel, Jeffrey L Bennetzen   +8 more
doaj   +1 more source