Results 81 to 90 of about 14,990 (203)

EZH2‐Mediated PHF10 Suppression Amplifies HMGB1/NF‐κB Axis That Confers Chemotherapy Resistance in Cholangiocarcinoma

Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.
ABSTRACT Chemoresistance represents a major threat to the treatment of human cancers, including cholangiocarcinoma (CHOL). Aberrant epigenetic events contribute most to the progression of CHOL and chemotherapy efficacy. PHF10, one subunit of SWI/SNF complex, expressed highly in tumours that correlated with tumorigenesis.
Qiushi Yin, Daning Lin, Weiqian Zeng, Shijing Gu, Chuangshi Zhu, Changfu Liang, Yan Yang   +6 more
wiley   +1 more source

Role of Retroelements in Frontotemporal Dementia Development

Frontiers in Bioscience-Scholar
Frontotemporal dementia (FTD) develops in proteinopathies involving TDP-43 (transactive response DNA-binding protein 43 kDa), tau, and FUS (fused in sarcoma) proteins, which possess antiviral properties and exert inhibitory effects on human transposable ...
Rustam Nailevich Mustafin
doaj   +1 more source

On the Origin and Evolutionary Relationships of the Reverse Transcriptases Associated With Type III CRISPR-Cas Systems

Frontiers in Microbiology, 2018
Reverse transcriptases (RTs) closely related to those encoded by group II introns but lacking the intron RNA structure have been found associated with type III clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems, a prokaryotic ...
Nicolás Toro, Francisco Martínez-Abarca, Alejandro González-Delgado, Mario Rodríguez Mestre   +3 more
doaj   +1 more source

Chimeric retrogenes suggest a role for the nucleolus in LINE amplification [PDF]

, 2007
Chimeric retrogenes, found in mammalian and fungal genomes, are bipartite elements composed of DNA copies of cellular transcripts either directly fused to each other or fused to the 3′ part of a LINE retrotransposon. These cellular transcripts correspond
Buzdin, Anton, Gogvadze, Elena, Lebrun, Marc-Henri   +2 more
core   +1 more source

Protein kinase R induced by type I interferons is a main regulator of reactive microglia in Zika virus infection

Glia, Volume 73, Issue 1, Page 80-104, January 2025.
Main Points Type I interferons (IFNs‐I) from ZIKV‐infected neurons shape the reactivity of non‐infected microglia PKR activates microglia's phagocytic, pro‐inflammatory and morphological response inducing STAT1 phosphorylation and IRF1 expression Abstract Microglial cells are the phagocytic cells of the brain that under physiological conditions ...
Violaine Bortolin, Zeyni Mansuroglu, Laurine Conquet, Gaetano Calcagno, Fanny Lambert, Jose Pablo Marin‐Obando, Helena Segrt, Mary Savino, Reyene Menidjel, Sylvie Souès, Luc Buée, Florence Niedergang, Marie‐Christine Galas, Xavier Montagutelli, Eliette Bonnefoy   +14 more
wiley   +1 more source

Comparative analysis of amphibian genomes: An emerging resource for basic and applied research

Molecular Ecology Resources, Volume 25, Issue 1, January 2025.
Abstract Amphibians are the most threatened group of vertebrates and are in dire need of conservation intervention to ensure their continued survival. They exhibit unique features including a high diversity of reproductive strategies, permeable and specialized skin capable of producing toxins and antimicrobial compounds, multiple genetic mechanisms of ...
Tiffany A. Kosch, Andrew J. Crawford, Rachel Lockridge Mueller, Katharina C. Wollenberg Valero, Megan L. Power, Ariel Rodríguez, Lauren A. O'Connell, Neil D. Young, Lee F. Skerratt   +8 more
wiley   +1 more source

Involvement of transposable elements in neurogenesis

Вавиловский журнал генетики и селекции, 2020
The article is about the role of transposons in the regulation of functioning of neuronal stem cells and mature neurons of the human brain. Starting from the first division of the zygote, embryonic development is governed by regular activations of ...
R. N. Mustafin, E. K. Khusnutdinova
doaj   +1 more source

Three Novel Spider Genomes Unveil Spidroin Diversification and Hox Cluster Architecture: Ryuthela nishihirai (Liphistiidae), Uloborus plumipes (Uloboridae) and Cheiracanthium punctorium (Cheiracanthiidae)

Molecular Ecology Resources, Volume 25, Issue 1, January 2025.
ABSTRACT Spiders are a hyperdiverse taxon and among the most abundant predators in nearly all terrestrial habitats. Their success is often attributed to key developments in their evolution such as silk and venom production and major apomorphies such as a whole‐genome duplication.
Yannis Schöneberg, Tracy Lynn Audisio, Alexander Ben Hamadou, Martin Forman, Jiří Král, Tereza Kořínková, Eva Líznarová, Christoph Mayer, Lenka Prokopcová, Henrik Krehenwinkel, Stefan Prost, Susan Kennedy   +11 more
wiley   +1 more source

Retrotransposon-Encoded Reverse Transcriptase in the Genesis, Progression and Cellular Plasticity of Human Cancer [PDF]

, 2011
LINE-1 (Long Interspersed Nuclear Elements) and HERVs (Human Endogenous Retroviruses) are two families of autonomously replicating retrotransposons that together account for about 28% of the human genome.
Matteucci, C, Sinibaldi Vallebona, P, Spadafora, C   +2 more
core   +2 more sources

A Novel Family of Mobile Genetic Elements Is Limited to the Germline Genome in \u3cem\u3eTetrahymena Thermophila\u3c/em\u3e [PDF]

, 2002
In the ciliated protozoan Tetrahymena thermophila, extensive DNA elimination is associated with differentiation of the somatic macronucleus from the germline micronucleus.
Gershan, Jill A., Karrer, Kathleen M., Li, Shuqiang, Lochowicz, Andrew J., Wuitschick, Jeffrey D.   +4 more
core   +2 more sources