Results 51 to 60 of about 49,871 (252)

Astrocytes Amplify Neuronal Dendritic Volume Transmission Stimulated by Norepinephrine

open access: yesCell Reports, 2019
Summary: In addition to their support role in neurotransmitter and ion buffering, astrocytes directly regulate neurotransmission at synapses via local bidirectional signaling with neurons.
Chun Chen   +5 more
doaj   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem   +17 more
wiley   +1 more source

Chloroplast retrograde regulation of heat stress responses in plants

open access: yesFrontiers in Plant Science, 2016
It is well known that intracellular signaling from chloroplast to nucleus plays a vital role in stress responses to survive environmental perturbations.
Ai-Zhen eSun, Fang-Qing eGuo
doaj   +1 more source

Chloroplast-localized GUN1 contributes to the acquisition of basal thermotolerance in Arabidopsis thaliana

open access: yesFrontiers in Plant Science, 2022
Heat stress (HS) severely affects different cellular compartments operating in metabolic processes and represents a critical threat to plant growth and yield.
Cecilia Lasorella   +7 more
doaj   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang   +8 more
wiley   +1 more source

The Yeast Retrograde Response as a Model of Intracellular Signaling of Mitochondrial Dysfunction

open access: yesFrontiers in Physiology, 2012
Mitochondrial dysfunction activates intracellular signaling pathways that impact yeast longevity, and the best known of these pathways is the retrograde response.
S. Michal eJazwinski, Andres eKriete
doaj   +1 more source

A Core Module of Nuclear Genes Regulated by Biogenic Retrograde Signals from Plastids

open access: yesPlants, 2021
Chloroplast biogenesis during seedling development of angiosperms is a rapid and highly dynamic process that parallels the light-dependent photomorphogenic programme.
Björn Grübler   +2 more
doaj   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin   +8 more
wiley   +1 more source

Self‐Assembled Calcite Architectures for Programmable Information Storage

open access: yesAdvanced Materials Technologies, EarlyView.
Programmable biomineralization enables the formation of 3D calcite architectures that encode information through spatially defined refractive‐index modulations. Data are written via laser‐directed mineralization, stored in stable voxelized mineral structures, and retrieved non‐destructively through optical diffraction, offering a pathway toward ultra ...
Congrui Jin   +2 more
wiley   +1 more source

Unique Axon-to-Soma Signaling Pathways Mediate Dendritic Spine Loss and Hyper-Excitability Post-axotomy

open access: yesFrontiers in Cellular Neuroscience, 2019
Axon damage may cause axon regeneration, retrograde synapse loss, and hyper-excitability, all of which affect recovery following acquired brain injury.
Tharkika Nagendran   +4 more
doaj   +1 more source

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