Results 31 to 40 of about 49,871 (252)
Mitochondrial retrograde signaling in the nervous system [PDF]
FEBS Letters, 2017 Mitochondria generate the majority of cellular ATP and are essential for neuronal function. Loss of mitochondrial activity leads to primary mitochondrial diseases and may contribute to neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Mitochondria communicate with the cell through mitochondrial retrograde signaling pathways. These
Rachel J. Hunt, Joseph M. Bateman
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eLife, 2017 Organelle-nuclear retrograde signaling regulates gene expression, but its roles in specialized cells and integration with hormonal signaling remain enigmatic. Here we show that the SAL1-PAP (3′-phosphoadenosine 5′- phosphate) retrograde pathway interacts
Wannarat Pornsiriwong +19 more
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Biologia Plantarum, 2018 Ethylene response factor (ERF) is a key transcription factor of plant ethylene signaling pathway, which plays an important role in plant response to abiotic and biotic stresses by regulating the expression of downstream genes.
W. Wu +6 more
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Mitochondrial dysfunction, UPRmt signaling, and targeted therapy in metastasis tumor
Cell & Bioscience, 2021 In modern research, mitochondria are considered a more crucial energy plant in cells. Mitochondrial dysfunction, including mitochondrial DNA (mtDNA) mutation and denatured protein accumulation, is a common feature of tumors.
Rajendiran Keerthiga +2 more
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A new alternative in plant retrograde signaling [PDF]
Genome Biology, 2014 AbstractThe reduced or oxidized state of plastoquinone in chloroplasts regulates splicing in the nucleus to control nuclear gene expression in response to changing environmental conditions.
Jung, Hou-Sung, Mockler, Todd C
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Chondroitinase ABC Promotes Axon Regeneration and Reduces Retrograde Apoptosis Signaling in Lamprey
Frontiers in Cell and Developmental Biology, 2021 Paralysis following spinal cord injury (SCI) is due to failure of axonal regeneration. It is believed that axon growth is inhibited by the presence of several types of inhibitory molecules in central nervous system (CNS), including the chondroitin ...
Jianli Hu +7 more
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Self-repair in a Bidirectionally Coupled Astrocyte-Neuron (AN) System based on Retrograde Signaling
Frontiers in Computational Neuroscience, 2012 In this paper we demonstrate that retrograde signaling via astrocytes may underpin self-repair in the brain. Faults manifest themselves in silent or near silent neurons caused by low transmission probability synapses; the enhancement of the transmission ...
John eWade +4 more
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Retrograde Signaling: A New Candidate Signaling Molecule [PDF]
The Plant Cell, 2011 Signaling from the chloroplast and mitochondria to the nucleus, termed retrograde signaling, regulates the expression of nuclear genes encoding organellar proteins and other cellular proteins to orchestrate organelle and cell development and metabolism.
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eLife, 2019 Axon degeneration sculpts neuronal connectivity patterns during development and is an early hallmark of several adult-onset neurodegenerative disorders. Substantial progress has been made in identifying effector mechanisms driving axon fragmentation, but
Guiping Wang +10 more
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Chloroplast retrograde signal regulates flowering [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Proper timing of flowering transition is vital for the reproductive success of plants and orchestrated by endogenous and external factors; however, the mechanisms of how plants regulate flowering under high light are not well understood. In this study, we show that promotion of flowering by high light
Feng, Peiqiang +11 more
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