Results 21 to 30 of about 91,585 (332)

Retrograde signaling via axonal transport through signaling endosomes

Journal of Pharmacological Sciences, 2019
Neurons extend axons far from cell bodies, and retrograde communications from distal axons to cell bodies and/or dendrites play critical roles in the development and maintenance of neuronal circuits.
Naoya Yamashita
doaj   +3 more sources

Combinatorial chemistry identifies additional compounds that selectively inhibit DLK-dependent retrograde signaling while minimally affecting other axonal roles of DLK [PDF]

Scientific Reports
Dual leucine-zipper kinase (DLK) is implicated in at least two distinct processes that drive neurodegeneration: retrograde (axon-to-soma) signaling to activate pro-degenerative transcription programs, and axon-intrinsic action to drive Wallerian and ...
Xiaotian Zhang, Heykyeong Jeong, Edward Melenski, John Gordon, Wayne E. Childers, Gareth M. Thomas   +5 more
doaj   +2 more sources

Another gun Dismantled: ABSCISIC ACID INSENSITIVE4 Is Not a Target of Retrograde Signaling [PDF]

, 2019
Article Commentary: News and Views.Peer ...
Amna Mhamdi, Charlotte M. M. Gommers
openalex   +5 more sources

Retrograde Coupling: Muscle’s Orphan Signaling Pathway? [PDF]

Biophysical Journal, 2016
In skeletal muscle excitation-contraction coupling, a voltage-gated calcium channel directly activates opening of the calcium release channel (RyR1) in the sarcoplasmic reticulum that supplies the calcium signal triggering contraction. In addition, a retrograde signal from the RyR1 facilitates gating of the voltage-gated calcium channel. Recent studies
Bernhard E. Flucher
openalex   +3 more sources

Plastid retrograde signaling: A developmental perspective. [PDF]

Plant Cell
Abstract Chloroplast activities influence nuclear gene expression, a phenomenon referred to as retrograde signaling. Biogenic retrograde signals have been revealed by changes in nuclear gene expression when chloroplast development is disrupted.
Loudya N, Barkan A, López-Juez E.
europepmc   +3 more sources

Coordinated cpSRP43 and cpSRP54 Abundance Is Essential for Tetrapyrrole Biosynthesis While cpSRP43 Is Independent of Retrograde Signaling [PDF]

Plants
The chloroplast signal recognition particle (cpSRP) components cpSRP43 and cpSRP54 not only form a complex with light-harvesting chlorophyll (Chl)-binding proteins to direct them to the thylakoid membrane, but also serve other functions.
Shuiling Ji, Huijiao Yao, Bernhard Grimm
doaj   +2 more sources

Retrograde Signaling: Understanding the Communication between Organelles. [PDF]

Int J Mol Sci, 2020
Understanding how cell organelles and compartments communicate with each other has always been an important field of knowledge widely explored by many researchers. However, despite years of investigations, one point—and perhaps the only point that many agree on—is that our knowledge about cellular-signaling pathways still requires expanding ...
Mielecki J, Gawroński P, Karpiński S.
europepmc   +4 more sources

Presynaptic nanoscale components of retrograde synaptic signaling [PDF]

Science Advances
While our understanding of the nanoscale architecture of anterograde synaptic transmission is rapidly expanding, the qualitative and quantitative molecular principles underlying distinct mechanisms of retrograde synaptic communication remain elusive.
Benjámin Barti, Barna Dudok, Kata Kenesei, Miklós Zöldi, Vivien Miczán, Gyula Y. Balla, Diana Zala, Mariana Tasso, Claudia Sagheddu, Máté Kisfali, Blanka Tóth, Marco Ledri, E. Sylvester Vizi, Miriam Melis, L Barna, Zsolt Lenkei, Iván Soltész, István Katona   +17 more
openalex   +6 more sources

A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. [PDF]

, 2015
Clues to Alzheimer disease (AD) pathogenesis come from a variety of different sources including studies of clinical and neuropathological features, biomarkers, genomics and animal and cellular models. An important role for amyloid precursor protein (APP)
Cheng, Soan, Goldstein, Lawrence SB, Mobley, William C, Natera-Naranjo, Orlangie, Nguyen, Phuong, Pearn, Matthew L, Reyna, Sol M, Tanzi, Rudolph E, Wagner, Steven L, Weissmiller, April M, Wu, Chengbiao, Zhao, Xiaobei   +11 more
core   +13 more sources

Biogenic retrograde signaling via GUN1 ensures thermotolerant chloroplast biogenesis during seedling establishment in Arabidopsis thaliana. [PDF]

J Integr Plant Biol
Qi S, Cui C, Xia J, Li M, Li M, Jeon JS, Kim C.   +6 more
europepmc   +3 more sources