Results 41 to 50 of about 49,871 (252)

Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling

eLife, 2018
The development of neurons in the peripheral nervous system is dependent on target-derived, long-range retrograde neurotrophic factor signals. The prevailing view is that target-derived nerve growth factor (NGF), the prototypical neurotrophin, and its ...
Mengchen Ye, Kathryn M Lehigh, David D Ginty   +2 more
doaj   +1 more source

Retrograde signaling from functionally heterogeneous plastids [PDF]

Frontiers in Plant Science, 2012
Structural and functional components of chloroplast are encoded by genes localized both to nuclear and plastid genomes of plant cell. Development from etioplasts to chloroplasts is triggered by light receptors that activate the expression of photosynthesis-associated nuclear genes (PhaNGs).
Lepistö, Anna, Toivola, Jouni, Nikkanen, Lauri, Rintamäki, Eevi   +3 more
openaire   +3 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

“Omics” insights into plastid behavior toward improved carotenoid accumulation

Frontiers in Plant Science, 2022
Plastids are a group of diverse organelles with conserved carotenoids synthesizing and sequestering functions in plants. They optimize the carotenoid composition and content in response to developmental transitions and environmental stimuli.
Yuanyuan Li, Yue Jian, Yuanyu Mao, Fanliang Meng, Zhiyong Shao, Tonglin Wang, Jirong Zheng, Qiaomei Wang, Lihong Liu   +8 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Retrograde adenosine/A2A receptor signaling facilitates excitatory synaptic transmission and seizures

Cell Reports
Summary: Retrograde signaling at the synapse is a fundamental way by which neurons communicate and neuronal circuit function is fine-tuned upon activity.
Kaoutsar Nasrallah, Coralie Berthoux, Yuki Hashimotodani, Andrés E. Chávez, Michelle C. Gulfo, Rafael Luján, Pablo E. Castillo   +6 more
doaj   +1 more source

ABI4 and its role in chloroplast retrograde communication

Frontiers in Plant Science, 2013
The acquisition of plastids is a landmark event in plant evolution. The proper functionality of these organelles depends on strict and continuous communication between the plastids and the nucleus to precisely adjust gene expression in response to the ...
Patricia eLeón, Josefat eGregorio, Elizabeth eCordoba   +2 more
doaj   +1 more source

Chloroplast Signaling: Retrograde Regulation Revelations [PDF]

Current Biology, 2011
Developing chloroplasts are able to communicate their status to the nucleus and regulate expression of genes whose products are needed for photosynthesis. Heme is revealed to be a signaling molecule for this retrograde communication.
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source