Results 61 to 70 of about 49,871 (252)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors

eLife, 2019
Reactive oxygen species (ROS)-dependent signaling pathways from chloroplasts and mitochondria merge at the nuclear protein RADICAL-INDUCED CELL DEATH1 (RCD1).
Alexey Shapiguzov, Julia P Vainonen, Kerri Hunter, Helena Tossavainen, Arjun Tiwari, Sari Järvi, Maarit Hellman, Fayezeh Aarabi, Saleh Alseekh, Brecht Wybouw, Katrien Van Der Kelen, Lauri Nikkanen, Julia Krasensky-Wrzaczek, Nina Sipari, Markku Keinänen, Esa Tyystjärvi, Eevi Rintamäki, Bert De Rybel, Jarkko Salojärvi, Frank Van Breusegem, Alisdair R Fernie, Mikael Brosché, Perttu Permi, Eva-Mari Aro, Michael Wrzaczek, Jaakko Kangasjärvi   +25 more
doaj   +1 more source

Molecular-Scale Dynamics of Long Range Retrograde Brain-Derived Neurotrophic Factor Transport Shaped by Cellular Spatial Context

Frontiers in Neuroscience, 2022
Retrograde neurotrophin (NT) transport is a specialized form of signal transduction used to conduct information from axons to the cell bodies of central and peripheral nervous system neurons.
Anke Vermehren-Schmaedick, Anke Vermehren-Schmaedick, Mark J. Olah, Damien Ramunno-Johnson, Keith A. Lidke, Michael S. Cohen, Tania Q. Vu   +6 more
doaj   +1 more source

Retrograde signalling as an informant of circadian timing [PDF]

New Phytologist, 2018
Contents Summary 1749 I. The circadian system is responsive to environmental change 1749 II. Photoassimilates regulate circadian timing 1750 III. Retrograde signals contribute to circadian timing 1750 IV. Conclusions 1752 Acknowledgements 1752 References 1752 SummaryThe circadian system comprises interlocking ...
openaire   +4 more sources

Retrograde apoptotic signaling by the p75 neurotrophin receptor [PDF]

Neuronal Signaling, 2017
Neurotrophins are target-derived factors necessary for mammalian nervous system development and maintenance. They are typically produced by neuronal target tissues and interact with their receptors at axonal endings. Therefore, locally generated neurotrophin signals must be conveyed from the axon back to the cell soma.
Pathak, Amrita, Carter, Bruce D.
openaire   +2 more sources

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

A role for nitric oxide-driven retrograde signaling in the consolidation of a fear memory

Frontiers in Behavioral Neuroscience, 2010
In both invertebrate and vertebrate models of synaptic plasticity, signaling via the putative “retrograde messenger” nitric oxide (NO) has been hypothesized to serve as a critical link between functional and structural alterations at pre- and
Kathie A Overeem, Kathie A Overeem, Kristie T Ota, Melissa S Monsey, Jonathan E Ploski, Glenn E Schafe, Glenn E Schafe   +6 more
doaj   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Recent Advances in Understanding Carotenoid Derived Signaling Molecules in Regulating Plant Growth and Development

Frontiers in Plant Science, 2015
Carotenoids (C40) are synthesized in plastids and perform numerous important functions in these organelles. In addition, carotenoids can be processed into smaller signaling molecules that regulate various phases of the plant’s life cycle.
Li eTian
doaj   +1 more source

Retrograde Signals Navigate the Path to Chloroplast Development [PDF]

Plant Physiology, 2017
Complex signaling networks between the chloroplast and the nucleus mediate the emergence of the seedling into the light and the establishment of photosynthesis.
Tamara Hernández-Verdeja, Åsa Strand
openaire   +2 more sources