Results 81 to 90 of about 91,585 (332)

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

“Omics” insights into plastid behavior toward improved carotenoid accumulation

Frontiers in Plant Science, 2022
Plastids are a group of diverse organelles with conserved carotenoids synthesizing and sequestering functions in plants. They optimize the carotenoid composition and content in response to developmental transitions and environmental stimuli.
Yuanyuan Li, Yue Jian, Yuanyu Mao, Fanliang Meng, Zhiyong Shao, Tonglin Wang, Jirong Zheng, Qiaomei Wang, Lihong Liu   +8 more
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Chloroplast retrograde regulation of heat stress responses in plants

Frontiers in Plant Science, 2016
It is well known that intracellular signaling from chloroplast to nucleus plays a vital role in stress responses to survive environmental perturbations.
Ai-Zhen eSun, Fang-Qing eGuo
doaj   +1 more source

The retrograde signaling protein GUN1 regulates tetrapyrrole biosynthesis. [PDF]

Proc Natl Acad Sci U S A, 2019
Shimizu T, Kacprzak SM, Mochizuki N, Nagatani A, Watanabe S, Shimada T, Tanaka K, Hayashi Y, Arai M, Leister D, Okamoto H, Terry MJ, Masuda T.   +12 more
europepmc   +2 more sources

Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior [PDF]

, 2017
Increased tonic activity of locus coeruleus noradrenergic (LC-NE) neurons induces anxiety-like and aversive behavior. While some information is known about the afferent circuitry that endogenously drives this neural activity and behavior, the downstream ...
Bhatti, Dionnet L., Bruchas, Michael R., Lawson, Lamley A., McCall, Jordan G., McElligott, Zoe A., Siuda, Edward R., Stuber, Garret D.   +6 more
core   +3 more sources

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Astrocytes Amplify Neuronal Dendritic Volume Transmission Stimulated by Norepinephrine

Cell Reports, 2019
Summary: In addition to their support role in neurotransmitter and ion buffering, astrocytes directly regulate neurotransmission at synapses via local bidirectional signaling with neurons.
Chun Chen, ZhiYing Jiang, Xin Fu, Diankun Yu, Hai Huang, Jeffrey G. Tasker   +5 more
doaj   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

The Yeast Retrograde Response as a Model of Intracellular Signaling of Mitochondrial Dysfunction

Frontiers in Physiology, 2012
Mitochondrial dysfunction activates intracellular signaling pathways that impact yeast longevity, and the best known of these pathways is the retrograde response.
S. Michal eJazwinski, Andres eKriete
doaj   +1 more source