Retrograde signaling in plants: A critical review focusing on the GUN pathway and beyond [PDF]
Plant Communications, 2023 Plastids communicate their developmental and physiological status to the nucleus via retrograde signaling, allowing nuclear gene expression to be adjusted appropriately.
Andreas S. Richter +6 more
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Mathematical modeling and analysis of mitochondrial retrograde signaling dynamics [PDF]
iScience, 2022 Summary: Mitochondria, semi-autonomous eukaryotic organelles, participate in energy production and metabolism, making mitochondrial quality control crucial.
Shao-Ting Chiu +2 more
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Retrograde and anterograde signaling in the crosstalk between chloroplast and nucleus
Frontiers in Plant Science, 2022 The chloroplast is a complex cellular organelle that not only performs photosynthesis but also synthesizes amino acids, lipids, and phytohormones. Nuclear and chloroplast genetic activity are closely coordinated through signaling chains from the nucleus ...
Masood Jan +3 more
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MORF2-mediated plastidial retrograde signaling is involved in stress response and skotomorphogenesis beyond RNA editing [PDF]
Frontiers in Plant Science, 2023 Retrograde signaling modulates the expression of nuclear genome-encoded organelle proteins to adjust organelle function in response to environmental cues.
Madhura M. Yapa +8 more
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Oxylipins in plastidial retrograde signaling [PDF]
Redox Biology, 2020 Oxylipins (compounds derived from the oxidation of polyunsaturated fatty acids) are essential in retrograde signaling emanating from plastids to the nucleus during plant developmental and stress responses. In this graphical review, we provide an overview
Paula Muñoz, Sergi Munné-Bosch
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Mitochondrial retrograde signaling in gastric cancer: mtDNA mutations, ROS-driven NF-κB/HIF-1α activation, and Warburg effect amplification [PDF]
Frontiers in PhysiologyMitochondrial retrograde signaling serves as a critical communication axis that links mitochondrial dysfunction to nuclear gene expression, shaping key pathways in gastric carcinogenesis.
Yanyan Bai, Wenbin Chen
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Combinatorial chemistry identifies additional compounds that selectively inhibit DLK-dependent retrograde signaling while minimally affecting other axonal roles of DLK [PDF]
Scientific ReportsDual leucine-zipper kinase (DLK) is implicated in at least two distinct processes that drive neurodegeneration: retrograde (axon-to-soma) signaling to activate pro-degenerative transcription programs, and axon-intrinsic action to drive Wallerian and ...
Xiaotian Zhang +5 more
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Coordinated cpSRP43 and cpSRP54 Abundance Is Essential for Tetrapyrrole Biosynthesis While cpSRP43 Is Independent of Retrograde Signaling [PDF]
PlantsThe chloroplast signal recognition particle (cpSRP) components cpSRP43 and cpSRP54 not only form a complex with light-harvesting chlorophyll (Chl)-binding proteins to direct them to the thylakoid membrane, but also serve other functions.
Shuiling Ji, Huijiao Yao, Bernhard Grimm
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Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling. [PDF]
PLoS Genetics, 2018 Mitochondrial dysfunction activates the mitochondrial retrograde signaling pathway, resulting in large scale changes in gene expression. Mitochondrial retrograde signaling in neurons is poorly understood and whether retrograde signaling contributes to ...
Olivia F Duncan +8 more
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The Role of Tetrapyrrole- and GUN1-Dependent Signaling on Chloroplast Biogenesis
Plants, 2021 Chloroplast biogenesis requires the coordinated expression of the chloroplast and nuclear genomes, which is achieved by communication between the developing chloroplasts and the nucleus.
Takayuki Shimizu, Tatsuru Masuda
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