Results 31 to 40 of about 55,792 (268)

Retrotransposon life cycle and its impacts on cellular responses

RNA Biology
Approximately 45% of the human genome is comprised of transposable elements (TEs), also known as mobile genetic elements. However, their biological function remains largely unknown.
Ahmad Luqman-Fatah, Kei Nishimori, Shota Amano, Yukiko Fumoto, Tomoichiro Miyoshi   +4 more
doaj   +1 more source

Virophages and retrotransposons colonize the genomes of a heterotrophic flagellate

eLife, 2021
Virophages can parasitize giant DNA viruses and may provide adaptive anti-giant virus defense in unicellular eukaryotes. Under laboratory conditions, the virophage mavirus integrates into the nuclear genome of the marine flagellate Cafeteria burkhardae ...
Thomas Hackl, Sarah Duponchel, Karina Barenhoff, Alexa Weinmann, Matthias G Fischer   +4 more
doaj   +1 more source

An age-of-allele test of neutrality for transposable element insertions [PDF]

, 2013
How natural selection acts to limit the proliferation of transposable elements (TEs) in genomes has been of interest to evolutionary biologists for many years.
Bergman, Casey M., Blumenstiel, Justin P., Chen, Xi, He, Miaomiao   +3 more
core   +2 more sources

Yeast retrotransposons

Current Opinion in Genetics & Development, 1992
In the decade since Ty elements were discovered, advocates have argued they could be used as a genetic entrée to elusive host-type functions required by retroviruses. However, the advent of the polymerase chain reaction, coupled with a boom in funding for human immunodeficiency virus research have moved retroviral research apace, raising questions as ...
openaire   +4 more sources

Scattered organization of the histone multigene family and transposable elements in Synbranchus

Genetics and Molecular Biology, 2014
The fish species Synbranchus marmoratus is widely distributed throughout the Neotropical region and exhibits a significant karyotype differentiation. However, data concerning the organization and location of the repetitive DNA sequences in the genomes of
Ricardo Utsunomia, José Carlos Pansonato-Alves, Priscilla Cardim Scacchetti, Claudio Oliveira, Fausto Foresti   +4 more
doaj   +1 more source

Lysosome-mediated processing of chromatin in senescence [PDF]

, 2013
Cellular senescence is a stable proliferation arrest, a potent tumor suppressor mechanism, and a likely contributor to tissue aging. Cellular senescence involves extensive cellular remodeling, including of chromatin structure. Autophagy and lysosomes are
Adams, Adams-Cioaba, Andre Ivanov, Barnhill, Barradas, Bodnar, Braig, Bridger, Butin-Israeli, Cao, Chen, Chen, Coffinier, Collado, Cosme-Blanco, Dang, David M. Nelson, De Cecco, De Cecco, De Vos, Demidenko, Di Micco, Duncan, Feldser, Feser, Fraga, Freund, Funayama, Glatz, Goldman, Graeme Hewitt, Gray-Schopfer, Gray-Schopfer, Greer, Hayflick, Hong Wu, Houben, Howard, Hunt, Ichijima, Iglesias-Bartolome, Imai, Indrani Manoharan, Ishidoh, Jeff Pawlikowski, Joao F. Passos, John van Tuyn, Kanfi, Kang, Kennedy, Klionsky, Kreiling, Krizhanovsky, Krtolica, Kuilman, Lamark, Laszlo, Lee, Maures, McManus, Michaloglou, Michishita, Narita, Narita, Narita, Omholt, O’Sullivan, Pankiv, Parisha P. Shah, Passos, Peleg, Peter D. Adams, Pollock, Pospelova, Ruhoy, Sagiv, Santos-Rosa, Scaffidi, Serrano, Shelley L. Berger, Shimi, Shimi, Siebold, Smolle, Smolle, Soutoglou, Suram, Taranjit Singh Rai, Tran, Vargas, Vergnes, Viktor I. Korolchuk, Villeponteau, Wang, Wood, Xue, Yang, Young, Zhang, Zhang, Ziegler-Birling   +100 more
core   +2 more sources

TUT-TUTting retrotransposons [PDF]

Nature Reviews Molecular Cell Biology, 2018
3′uridylation by TUT4 and TUT7 is shown as a post-transcriptional mechanism restricting retrotransposition of LINE-1 elements and also replication of animal RNA viruses.
openaire   +2 more sources

Paralog-Specific Functions of RPL7A and RPL7B Mediated by Ribosomal Protein or snoRNA Dosage in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2017
Most ribosomal proteins in Saccharomyces cerevisiae are encoded by two paralogs that additively produce the optimal protein level for cell growth. Nonetheless, deleting one paralog of most ribosomal protein gene pairs results in a variety of phenotypes ...
Ryan J. Palumbo, Gabriele Fuchs, Sheila Lutz, M. Joan Curcio   +3 more
doaj   +1 more source

Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing [PDF]

, 2014
Retrotransposons constitute a major source of genetic variation, and somatic retrotransposon insertions have been reported in cancer. Here, we applied TranspoSeq, a computational framework that identifies retrotransposon insertions from sequencing data ...
Getz, Gad, Helman, Elena, Lawrence, Michael S., Meyerson, Matthew L., Sougnez, Carrie, Stewart, Chip   +5 more
core   +1 more source

Retrotransposon Domain Swapping [PDF]

The Plant Cell, 2010
Whether you consider them major genomic parasites or potentially major drivers of genome expansion, long terminal repeat (LTR) retrotransposons are major, making up 15 to 90% of plant nuclear genomes (reviewed in Sabot and Schulman, 2006). These elements transpose by a replicate-and-paste mechanism, wherein an RNA copy of the retrotransposon is reverse
openaire   +2 more sources