Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer's disease. [PDF]
PLoS ONE, 2019 Alzheimer's disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease.
Deborah A Roby +9 more
doaj +7 more sources
REV-ERB is essential in cardiac fibroblasts homeostasis [PDF]
Frontiers in Pharmacology, 2022 REV-ERB agonists have shown antifibrotic effects in the heart and other organs. The function of REV-ERB in the cardiac fibroblasts remains unstudied. Here, we characterize the functional difference of REV-ERB in mouse embryonic fibroblasts and cardiac ...
Xiaokang Luo +11 more
doaj +5 more sources
SR9009 improves heart function after pressure overload independent of cardiac REV-ERB [PDF]
Frontiers in Cardiovascular Medicine, 2022 The core clock component REV-ERB is essential for heart function. Previous studies show that REV-ERB agonist SR9009 ameliorates heart remodeling in the pressure overload model with transverse aortic constriction (TAC).
Hui Li +10 more
doaj +5 more sources
Exercise alters the circadian rhythm of REV-ERB-α and downregulates autophagy-related genes in peripheral and central tissues [PDF]
Scientific Reports, 2022 The transcriptional repressor REV-ERB-α, encoded by Nuclear Receptor Subfamily 1 Group D Member 1 (Nr1d1), has been considered to play an essential role in the skeletal muscle oxidative capacity adaptation and muscle mass control.
Alisson L. da Rocha +12 more
doaj +4 more sources
Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB [PDF]
Nature Communications, 2022 The nuclear receptor REV-ERBα is a receptor for heme and plays a role in a range of physiological processes. Here, the authors provide the first structure of REV-ERB bound to a synthetic nonporphyrin ligand defining key mechanistic differences to how ...
Meghan H. Murray +10 more
doaj +4 more sources
REV-ERB agonism improves liver pathology in a mouse model of NASH [PDF]
PLoS ONE, 2020 Non-alcoholic fatty liver disease (NAFLD) affects a significant number of people worldwide and currently there are no pharmacological treatments. NAFLD often presents with obesity, insulin resistance, and in some cases cardiovascular diseases. There is a
Kristine Griffett +4 more
doaj +6 more sources
Hindbrain REV-ERB nuclear receptors regulate sensitivity to diet-induced obesity and brown adipose tissue pathophysiology [PDF]
Molecular Metabolism, 2023 Objective: The dorsal vagal complex (DVC) of the hindbrain is a major point of integration for central and peripheral signals that regulate a wide variety of metabolic functions to maintain energy balance.
Lauren N. Woodie +7 more
doaj +3 more sources
Role of circadian transcription factor REV-ERB in cardiovascular diseases: a review [PDF]
Frontiers in Cardiovascular MedicineCircadian rhythm, or the biological clock, is an intrinsic timing system present in organisms that operates on a cycle of approximately 24 h. Nearly every cell in the human body adheres to a specific circadian rhythm, governing various biological ...
Chunling Wang +11 more
doaj +5 more sources
Rev-erb agonist improves adverse cardiac remodeling and survival in myocardial infarction through an anti-inflammatory mechanism. [PDF]
PLoS ONE, 2017 Rev-erb α, known as nuclear receptor 1D1 (NR1D1), regulates circadian rhythm, modulates glucose and lipid metabolism, and inflammatory response. However, little is known about the effect of Rev-erb agonist on the progression of myocardial infarction (MI)
Endin Nokik Stujanna +12 more
doaj +5 more sources
The Small Molecule SR8278 Inhibits Cell Proliferation Independent of the REV-ERB Nuclear Receptor Proteins in Human Keratinocytes [PDF]
BiomoleculesThe small molecule SR8278 was initially identified as an antagonist of the REV-ERB (reverse c-ERBAa) nuclear receptor proteins, which play important roles in metabolism and circadian rhythms.
Ushaswini Atluri +2 more
doaj +4 more sources