REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity. [PDF]
Nature, 2021 Systemic insulin sensitivity shows a diurnal rhythm with a peak upon waking1,2. The molecular mechanism that underlies this temporal pattern is unclear.
Ding G +22 more
europepmc +10 more sources
Rev-erbs and Glia—Implications for Neurodegenerative Diseases [PDF]
Journal of Experimental Neuroscience, 2019 Recently, we described a role for the circadian clock protein and nuclear receptor Rev-erbα in regulating glial activation states in the brain. Deletion of Rev-erbα resulted in microglial as well as astrocytic activation, while a Rev-erbα agonist ...
Percy Griffin +2 more
doaj +7 more sources
Muscle Rev-erb controls time-dependent adaptations to chronic exercise in mice [PDF]
Nature CommunicationsThe best time of the day for chronic exercise training and the mechanism underlying the timing effects is unclear. Here, we show that low-intensity, low-volume treadmill training in mice before sleep yields greater benefits than after waking for muscle ...
Jidong Liu +15 more
doaj +4 more sources
The role of REV-ERB in NASH. [PDF]
Acta Pharmacol Sin, 2022 REV-ERBs are atypical nuclear receptors as they function as ligand-regulated transcriptional repressors. The natural ligand for the REV-ERBs (REV-ERBα and REV-ERBβ) is heme, and heme-binding results in recruitment of transcriptional corepressor proteins such as N-CoR that mediates repression of REV-ERB target genes. These two receptors regulate a large
Griffett K +3 more
europepmc +5 more sources
Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages [PDF]
eLife, 2016 Although macrophages can be polarized to distinct phenotypes in vitro with individual ligands, in vivo they encounter multiple signals that control their varied functions in homeostasis, immunity, and disease.
Dawn Z Eichenfield +12 more
doaj +4 more sources
In Vitro Metabolic Studies of REV-ERB Agonists SR9009 and SR9011. [PDF]
Int J Mol Sci, 2016 SR9009 and SR9011 are attractive as performance-enhancing substances due to their REV-ERB agonist effects and thus circadian rhythm modulation activity.
Geldof L +4 more
europepmc +7 more sources
Altered clock gene expression in obese visceral adipose tissue is associated with metabolic syndrome. [PDF]
PLoS ONE, 2014 Clock gene expression was associated with different components of metabolic syndrome (MS) in human adipose tissue. However, no study has been done to compare the expression of clock genes in visceral adipose tissue (VAT) from lean and obese subjects and ...
Elaine Vieira +8 more
doaj +3 more sources
REV-ERB ALPHA polymorphism is associated with obesity in the Spanish obese male population. [PDF]
PLoS ONE, 2014 REV-ERB ALPHA has been shown to link metabolism with circadian rhythms. We aimed to identify new polymorphisms in the promoter of REV-ERB ALPHA and tested whether these polymorphisms could be associated with obesity in the Spanish population. Of the 1197
Elena G Ruano +2 more
doaj +3 more sources
Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells. [PDF]
PLoS ONE, 2013 Disruption of pancreatic clock genes impairs pancreatic beta-cell function, leading to the onset of diabetes. Despite the importance of pancreatic alpha-cells in the regulation of glucose homeostasis and in diabetes pathophysiology, nothing is known ...
Elaine Vieira +8 more
doaj +4 more sources
REV-ERB activation as a novel pharmacological approach for treating inflammatory pain [PDF]
Frontiers in Pharmacology, 2023 Pain is a complex problem affecting millions of people worldwide. The current therapies to reduce pain are limited as many treatment options inadequately address the causes of pain, lead to tolerance of the drug, or have adverse effects including abuse ...
Sangeet Makhija +7 more
doaj +2 more sources