Normal circadian period length requires repression of Npas2 by REV-ERB nuclear receptors [PDF]
Cell ReportsSummary: REV-ERB nuclear receptors are integrated into the molecular circadian clock present in most mammalian cells. Loss of REV-ERBs (REV-ERB DKO) within the suprachiasmatic nucleus (SCN) in vivo leads to a marked shortening of the circadian period ...
Michael C. Tackenberg +5 more
doaj +2 more sources
Direct regulation of CLOCK expression by REV-ERB. [PDF]
PLoS ONE, 2011 Circadian rhythms are regulated at the cellular level by transcriptional feedback loops leading to oscillations in expression of key proteins including CLOCK, BMAL1, PERIOD (PER), and CRYPTOCHROME (CRY).
Christine Crumbley, Thomas P Burris
doaj +4 more sources
Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation. [PDF]
PLoS ONE, 2016 The circadian clock maintains appropriate timing for a wide range of behaviors and physiological processes. Circadian behaviors such as sleep and wakefulness are intrinsically dependent on the precise oscillation of the endogenous molecular machinery ...
Ariadna Amador +5 more
doaj +4 more sources
Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy [PDF]
, 2013 The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism, adipogenesis and the inflammatory response in macrophages. We show here that Rev-erb-α is highly expressed in oxidative skeletal muscle and plays a role in mitochondrial ...
Estelle Woldt +17 more
openalex +5 more sources
Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome [PDF]
Molecular Metabolism, 2017 Objective: The loss of skeletal muscle mass and strength are a central feature of traumatic injury and degenerative myopathies. Unfortunately, pharmacological interventions typically fail to stem the long-term decline in quality of life.
Ryan D. Welch +11 more
doaj +2 more sources
Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression. [PDF]
PLoS ONE, 2016 The nuclear receptors REV-ERBα and REV-ERBβ are transcription factors that play pivotal roles in the regulation of the circadian rhythm and various metabolic processes.
Ariadna Amador +5 more
doaj +3 more sources
Adropin: An endocrine link between the biological clock and cholesterol homeostasis [PDF]
Molecular Metabolism, 2018 Objective: Identify determinants of plasma adropin concentrations, a secreted peptide translated from the Energy Homeostasis Associated (ENHO) gene linked to metabolic control and vascular function.
Sarbani Ghoshal +22 more
doaj +3 more sources
Modifier Genes as Therapeutics: The Nuclear Hormone Receptor Rev Erb Alpha (Nr1d1) Rescues Nr2e3 Associated Retinal Disease [PDF]
, 2014 Nuclear hormone receptors play a major role in many important biological processes. Most nuclear hormone receptors are ubiquitously expressed and regulate processes such as metabolism, circadian function, and development. They function in these processes
Nelly M. Cruz +7 more
openalex +7 more sources
P060 Hypoxia-induced overexpression of Rev-Erb-alpha and NPAS2 proteins in obstructive sleep apnea patients - possible mechanism of DM2 development [PDF]
Sleep Adv, 2021 Karuga F +5 more
europepmc +3 more sources
Biomedical JournalBackground: Obesity and circadian rhythm disruption are significant global health concerns, contributing to an increased risk of metabolic disorders. Both adipose tissue and circadian rhythms play critical roles in maintaining energy homeostasis, and ...
Ming-Yu Yang +5 more
doaj +2 more sources