Results 51 to 60 of about 7,238 (191)

REV-ERB and ROR nuclear receptors as drug targets [PDF]

Nature Reviews Drug Discovery, 2014
The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are involved in many physiological processes, including regulation of metabolism, development and immunity as well as the circadian rhythm.
Douglas J, Kojetin, Thomas P, Burris
openaire   +2 more sources

The nuclear receptor Rev-erb-Α regulates vascular calcification [PDF]

Atherosclerosis
Lise Ferri, Cécilia Bellengier, Jean‐Baptiste Julla, Antonino Bongiovanni, Stéphane Delhaye, Christian Duhem, Quentin Thorel, Aurore Hebras, Bettina Ram, Margaux Leduc, Marie Bicharel, Alicia Mayeuf-Louchart, Yasmine Sebti, Meryem Tardivel, Nicolas Venteclef, Bart Staels, Jean–François Gautier, Benoît Pourcet, Hélène Duez   +18 more
openalex   +2 more sources

Repetitive mild traumatic brain injury alters central and peripheral clock gene expression in the adolescent rat

Neurobiology of Sleep and Circadian Rhythms, 2023
Mild traumatic brain injury (mTBI) or concussion is a common injury worldwide leading to substantial medical costs and a high burden on society. In adolescents, falls and sports related trauma are often the causes of mTBI.
Marissa Sgro, Susanne Ellens, Zoe N. Kodila, Jennaya Christensen, Crystal Li, Richelle Mychasiuk, Glenn R. Yamakawa   +6 more
doaj   +1 more source

Pumping up the metabolic Rev-ERB [PDF]

Science-Business eXchange, 2012
Two teams have shown that Rev-ERBAs play a central role in regulating the circadian clock and metabolism and a third group has found that agonizing the receptors treated obesity in mice, suggesting Rev-ERBA agonists could help treat a range of metabolic diseases.
openaire   +1 more source

The transcriptional repressor REV-ERB as a novel target for disease

Bioorganic & Medicinal Chemistry Letters, 2020
REV-ERB is a member of the nuclear receptor superfamily of transcription factors involved in the regulation of many physiological processes, from circadian rhythm, to immune function and metabolism. Accordingly, REV-ERB has been considered as a promising, but difficult drug target for the treatment of numerous diseases.
Amaia Uriz-Huarte, Amrita Date, Heather Ang, Simak Ali, Hugh J.M. Brady, Matthew J. Fuchter   +5 more
openalex   +5 more sources

A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity. [PDF]

Proceedings of the National Academy of Sciences, 1996
Rev-erb alpha belongs to the nuclear receptor superfamily, which contains receptors for steroids, thyroid hormones, retinoic acid, and vitamin D, as well as "orphan" receptors. No ligand has been found for Rev-erb alpha to date, making it one of these orphan receptors.
G, Adelmant, A, Bègue, D, Stéhelin, V, Laudet   +3 more
openaire   +2 more sources

Adipocyte NR1D1 dictates adipose tissue expansion during obesity

eLife, 2021
The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of lipid metabolism, with global Nr1d1 deletion driving dysregulation of white adipose tissue (WAT) lipogenesis and obesity.
Ann Louise Hunter, Charlotte E Pelekanou, Nichola J Barron, Rebecca C Northeast, Magdalena Grudzien, Antony D Adamson, Polly Downton, Thomas Cornfield, Peter S Cunningham, Jean-Noel Billaud, Leanne Hodson, Andrew SI Loudon, Richard D Unwin, Mudassar Iqbal, David W Ray, David A Bechtold   +15 more
doaj   +1 more source

SR9009 has REV-ERB-independent effects on cell proliferation and metabolism. [PDF]

Proc Natl Acad Sci U S A, 2019
The nuclear receptors REV-ERBα and -β link circadian rhythms and metabolism. Like other nuclear receptors, REV-ERB activity can be regulated by ligands, including naturally occurring heme. A putative ligand, SR9009, has been reported to elicit a range of beneficial effects in healthy as well as diseased animal models and cell systems.
Dierickx P, Emmett MJ, Jiang C, Uehara K, Liu M, Adlanmerini M, Lazar MA.   +6 more
europepmc   +4 more sources

Nuclear receptors in vascular biology [PDF]

, 2015
Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics.
A Chawla, A McCurley, AA Hamers, AL Bookout, B Fisslthaler, BG Hoebel, C McCarthy, C Zhou, CH Lee, CK Glass, CK Huang, CT Lee, D Bishop-Bailey, D Bishop-Bailey, David Bishop-Bailey, DP Edwards, E Gerlach, F Akbiyik, FA Pereira, FL Wynne, FY Ali, G Pascual, I Dussault, I Spoletini, J He, J Qin, J Sonoda, J Xiang, K Spruiell, KE Swales, L Calza, L Li, L Piqueras, LA Moraes, LA Moraes, LJ Jonk, LR You, M Kaushik, M Matic, N Albermann, N Schafer, N Takamoto, Q Qin, R Zhao, S Asgary, S Chakrabarti, S Marino De, S Stein, SA Kliewer, V Zoete, W El-Sankary, WC Lau, X Wang, Y Ma, Y Sui, Y Sui, YW Hu   +56 more
core   +3 more sources

REV-ERBs: More Than the Sum of the Individual Parts [PDF]

Cell Metabolism, 2012
REV-ERB nuclear receptors have been believed to stabilize the circadian clock machinery through an accessory but dispensable feedback loop. Recent work now challenges this assumption by demonstrating that REV-ERBs are essential core clock components, in addition to serving as pivotal regulators of rhythmic metabolism.
Stratmann Markus, Schibler Ueli
openaire   +2 more sources