Results 1 to 10 of about 123,223 (130)
Is reverse cholesterol transport regulated by active cholesterol? [PDF]
J Lipid Res, 2023 This review considers the hypothesis that a small portion of plasma membrane cholesterol regulates reverse cholesterol transport in coordination with overall cellular homeostasis. It appears that almost all of the plasma membrane cholesterol is held in stoichiometric complexes with bilayer phospholipids.
Steck TL, Lange Y.
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Cholesterol Efflux and Reverse Cholesterol Transport [PDF]
, 2014 Both alterations of lipid/lipoprotein metabolism and inflammatory events contribute to the formation of the atherosclerotic plaque, characterized by the accumulation of abnormal amounts of cholesterol and macrophages in the artery wall. Reverse cholesterol transport (RCT) may counteract the pathogenic events leading to the formation and development of ...
FAVARI, Elda +5 more
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Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy. [PDF]
J Diabetes Res, 2021 Cholesterol esters, synthesized from cholesterol with long-chain fatty acids, are essential components of plasma lipoproteins and cell membranes that participate in various metabolic processes in the body. Cholesterol can be excreted through the cholesterol reverse transport (RCT) pathway when excessive cholesterol is produced in the extrahepatic cells,
Zhang X, Wang K, Zhu L, Wang Q.
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Reverse cholesterol transport and hepatic osteodystrophy. [PDF]
Cell Metab, 2022 In this issue of Cell Metabolism, Lu et al. show that chronic liver disease increases the expression and activity of PP2Ac, a phosphatase that downregulates the excretion of lecithin-cholesterol aceyltransferase (LCAT). LCAT, a liver-derived enzyme, protects bone and prevents bone loss, and its lowered levels in progressive liver injury cause hepatic ...
Zaidi M, Yuen T, Iqbal J.
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Apoprotein E and Reverse Cholesterol Transport. [PDF]
Int J Mol Sci, 2018 Apoprotein E (apoE) is a multifunctional protein. Its best-characterized function is as a ligand for low-density lipoprotein (LDL) receptor family members to mediate the clearance of apoB-containing atherogenic lipoproteins. Among its other functions, apoE is involved in cholesterol efflux, especially from cholesterol-loaded macrophage foam cells and ...
Getz GS, Reardon CA.
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HDL and Reverse Cholesterol Transport. [PDF]
Circ Res, 2019 Cardiovascular disease, with atherosclerosis as the major underlying factor, remains the leading cause of death worldwide. It is well established that cholesterol ester-enriched foam cells are the hallmark of atherosclerotic plaques. Multiple lines of evidence support that enhancing foam cell cholesterol efflux by HDL (high-density lipoprotein ...
Ouimet M, Barrett TJ, Fisher EA.
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HDL and Reverse Cholesterol Transport Biomarkers. [PDF]
Methodist Debakey Cardiovasc J, 2019 High-density lipoprotein (HDL) is a protein-lipid nanoparticle that has predominately been characterized by its cholesterol concentration (HDL-C). Recent studies have challenged the presumed inverse association between HDL-C and cardiovascular events, suggesting a more U-shaped association.
Riggs KA, Rohatgi A.
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Reverse Cholesterol Transport and Atherosclerosis. [PDF]
Arterioscler Thromb Vasc Biol, 2019 Rohatgi A.
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Reverse Cholesterol Transport [PDF]
Cor et Vasa, 2006 Atherosclerosis, the accumulation of cholesterol in the arteries resulting in heart attacks and strokes, is the leading cause of death in the USA and most other industrialized countries in the world. Plasma levels of high-density lipoprotein (HDL) cholesterol are invariably found to be inversely associated with the risk of atherosclerosis.
Daniel L. Sparks +4 more
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Reverse cholesterol transport and cholesterol efflux in atherosclerosis [PDF]
QJM: An International Journal of Medicine, 2005 Reverse cholesterol transport (RCT) is a pathway by which accumulated cholesterol is transported from the vessel wall to the liver for excretion, thus preventing atherosclerosis. Major constituents of RCT include acceptors such as high-density lipoprotein (HDL) and apolipoprotein A-I (apoA-I), and enzymes such as lecithin:cholesterol acyltransferase ...
C Chen +4 more
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