Regulation of biliary cholesterol secretion and reverse cholesterol transport [PDF]
, 2016 According to the World Health Organization the number one cause of death throughout the world is cardiovascular disease. Therefore, there is an urgent need for new therapeutic strategies to prevent and treat cardiovascular disease. One possible way is to
Dikkers, Arne
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The secondary structure of apolipoprotein A-I on 9.6-nm reconstituted high-density lipoprotein determined by EPR spectroscopy. [PDF]
, 2013 Apolipoprotein A-I (ApoA-I) is the major protein component of high-density lipoprotein (HDL), and is critical for maintenance of cholesterol homeostasis.
Borja, Mark S +5 more
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A New Frontier for Reverse Cholesterol Transport [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2017 Numerous epidemiological studies have demonstrated that high-density lipoprotein cholesterol (HDL-C) levels are inversely associated with cardiovascular risk.1 However, despite intense efforts to develop new pharmacological strategies to increase HDL-C levels, such as with niacin and cholesteryl ester transfer protein inhibitors, few robust ...
Kazuhiro Nakaya +2 more
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Tachometer for Reverse Cholesterol Transport? [PDF]
Journal of the American Heart Association, 2012 Many clinical and epidemiological studies, as well as meta-analyses thereof, have shown the inverse relationship of high-density lipoprotein cholesterol (HDL-C) and apoliopoprotein (apo) A-I plasma levels with the risk of coronary artery disease.[1][1] HDL particles and their protein and ...
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Beyond High-Density Lipoprotein Cholesterol Levels Evaluating High-Density Lipoprotein Function as Influenced by Novel Therapeutic Approaches [PDF]
, 2008 A number of therapeutic strategies targeting high-density lipoprotein (HDL) cholesterol and reverse cholesterol transport are being developed to halt the progression of atherosclerosis or even induce regression.
deGoma, Emil M. +2 more
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The role of the lymphatic system in cholesterol transport [PDF]
, 2015 Reverse cholesterol transport (RCT) is the pathway for removal of peripheral tissue cholesterol and involves transport of cholesterol back to liver for excretion, starting from cellular cholesterol efflux facilitated by lipid-free apolipoprotein A1 ...
Andrew Elvington +2 more
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Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: A new paradigm for drug discovery [PDF]
, 2020 Epidemiological results revealed that there is an inverse correlation between high-density lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease (ASCVD).
Huang, Hui +3 more
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Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice [PDF]
, 2013 Reverse cholesterol transport (RCT) refers to the mobilization of cholesterol on HDL particles (HDL-C) from extravascular tissues to plasma, ultimately for fecal excretion. Little is known about how HDL-C leaves peripheral tissues to reach plasma.
Martel, Catherine +13 more
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Physical Fitness and Reverse Cholesterol Transport [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2004 Background— Physical exercise is associated with a decreased risk of cardiovascular disease, which may be partly caused by the effect of exercise on the lipoprotein profile. The most consistent effect of exercise on lipoprotein metabolism is an increase in high-density lipoprotein (HDL).
Anh Hoang +6 more
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Functionality of HDL particles: Heterogeneity and relationships to cardiovascular disease [PDF]
, 2011 SummaryEpidemiological studies have firmly identified low plasma levels of high-density lipoprotein-cholesterol (HDL-C) as a strong and independent risk factor for coronary heart disease.
Camont, L., Chapman, J., Kontush, A.
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