Results 11 to 20 of about 113,812 (280)
Cyclosporine A impairs the macrophage reverse cholesterol transport in mice by reducing sterol fecal excretion. [PDF]
PLoS ONE, 2013 Despite the efficacy in reducing acute rejection events in organ transplanted subjects, long term therapy with cyclosporine A is associated with increased atherosclerotic cardiovascular morbidity.
Ilaria Zanotti +7 more
doaj +3 more sources
Reverse Cholesterol Transport and Atherosclerosis Regression [PDF]
Circulation, 1999 Cholesterol is the major component of atherosclerotic plaque. Cholesterol accumulation within atherosclerotic plaque occurs when cholesterol influx into the arterial wall (from apoB-containing lipoproteins) exceeds cholesterol efflux. Increased influx of cholesterol into the arterial wall is accompanied by an increased influx of monocytes/macrophages,1
D K Spady
openaire +3 more sources
LDL Contributes to Reverse Cholesterol Transport [PDF]
Circulation Research, 2020 Arnold von Eckardstein
openaire +4 more sources
Reverse cholesterol transport and cholesterol efflux in atherosclerosis [PDF]
QJM: An International Journal of Medicine, 2005 Reverse cholesterol transport (RCT) is a pathway by which accumulated cholesterol is transported from the vessel wall to the liver for excretion, thus preventing atherosclerosis. Major constituents of RCT include acceptors such as high-density lipoprotein (HDL) and apolipoprotein A-I (apoA-I), and enzymes such as lecithin:cholesterol acyltransferase ...
C Chen +4 more
openaire +3 more sources
Structure of benzothiadiazine at zwitterionic phospholipid cell membranes [PDF]
, 2021 The use of drugs derived from benzothiadiazine, which is a bicyclic heterocyclic benzene derivative, has become a widespread treatment for diseases such as hypertension (treated with diuretics such as bendroflumethiazide or chlorothiazide), low blood sugar (treated with non-diuretic diazoxide) or the human immunodeficiency virus, among others.
arxiv +1 more source
A New Frontier for Reverse Cholesterol Transport [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2017 Numerous epidemiological studies have demonstrated that high-density lipoprotein cholesterol (HDL-C) levels are inversely associated with cardiovascular risk.1 However, despite intense efforts to develop new pharmacological strategies to increase HDL-C levels, such as with niacin and cholesteryl ester transfer protein inhibitors, few robust ...
Kazuhiro Nakaya +2 more
openaire +3 more sources
Tachometer for Reverse Cholesterol Transport? [PDF]
Journal of the American Heart Association, 2012 Many clinical and epidemiological studies, as well as meta-analyses thereof, have shown the inverse relationship of high-density lipoprotein cholesterol (HDL-C) and apoliopoprotein (apo) A-I plasma levels with the risk of coronary artery disease.[1][1] HDL particles and their protein and ...
openaire +4 more sources
Apoprotein E and Reverse Cholesterol Transport [PDF]
International Journal of Molecular Sciences, 2018 Apoprotein E (apoE) is a multifunctional protein. Its best-characterized function is as a ligand for low-density lipoprotein (LDL) receptor family members to mediate the clearance of apoB-containing atherogenic lipoproteins. Among its other functions, apoE is involved in cholesterol efflux, especially from cholesterol-loaded macrophage foam cells and ...
Catherine A. Reardon, Godfrey S. Getz
openaire +2 more sources
Human immunodeficiency virus impairs reverse cholesterol transport from macrophages. [PDF]
PLoS Biology, 2006 Several steps of HIV-1 replication critically depend on cholesterol. HIV infection is associated with profound changes in lipid and lipoprotein metabolism and an increased risk of coronary artery disease.
Zahedi Mujawar +11 more
doaj +1 more source
Unresolved excess accumulation of myelin-derived cholesterol contributes to scar formation after spinal cord injury [PDF]
arXiv, 2022 Background: Spinal cord injury triggers complex pathological cascades, resulting in destructive tissue damage and incomplete tissue repair. Scar formation is generally considered as a barrier for regeneration in central nervous system (CNS), while the intrinsic mechanism of scar-forming after spinal cord injury has not been completed deciphered ...
arxiv