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Reverse cholesterol transport: Physiology and pharmacology
Atherosclerosis, 1991Reverse cholesterol transport identifies a series of metabolic events resulting in the transport of cholesterol from peripheral tissues to the liver and plays a major role in maintaining cholesterol homeostasis in the body. High density lipoproteins (HDL) are the vehicle of cholesterol in this reverse transport, a function believed to explain the ...
G. FRANCESCHINI, P. MADERNA, C. SIRTORI
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Drug control of reverse cholesterol transport
Pharmacology & Therapeutics, 1994Reverse cholesterol transport identifies a series of metabolic events resulting in the transport of excess cholesterol from peripheral tissues to the liver. High-density lipoproteins (HDL) are the vehicle of cholesterol in this reverse transport, a function believed to explain the inverse correlation between plasma HDL levels and atherosclerosis.
G. FRANCESCHINI, J. WERBA, L. CALABRESI
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Reverse cholesterol transport and hepatic osteodystrophy
Cell Metabolism, 2022In this issue of Cell Metabolism, Lu et al. show that chronic liver disease increases the expression and activity of PP2Ac, a phosphatase that downregulates the excretion of lecithin-cholesterol aceyltransferase (LCAT). LCAT, a liver-derived enzyme, protects bone and prevents bone loss, and its lowered levels in progressive liver injury cause hepatic ...
Mone, Zaidi, Tony, Yuen, Jameel, Iqbal
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Reverse cholesterol transport in diabetes mellitus
Diabetes/Metabolism Research and Reviews, 2000There are epidemiological data and experimental animal models relating the development of premature atherosclerosis with defects of the reverse cholesterol transport (RCT) system. In this regard, the plasma concentrations of the high density lipoprotein (HDL) subfractions, of cholesteryl ester transfer protein (CETP), as well as the activity of the ...
W.L. Medina +2 more
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1994
The plasma concentrations of the different plasma lipoproteins have been associated with coronary artery disease since the pioneering ultracentrifugal studies of John Gofman and his colleagues in Berkeley in the late 1940s1’2. The direct correlation of the concentration of the cholesteryl ester-rich low density lipoproteins (LDL)* with cholesterol ...
Jeffrey M. Hoeg, Alan T. Remaley
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The plasma concentrations of the different plasma lipoproteins have been associated with coronary artery disease since the pioneering ultracentrifugal studies of John Gofman and his colleagues in Berkeley in the late 1940s1’2. The direct correlation of the concentration of the cholesteryl ester-rich low density lipoproteins (LDL)* with cholesterol ...
Jeffrey M. Hoeg, Alan T. Remaley
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Current Opinion in Lipidology, 1991
New research firmly establishes the reverse cholesterol transport pathway, which carries cholesterol through the high-density lipoprotein, as significant in normal cholesterol homeostasis. Modulation of this pathway by transgenic and pharmacological techniques indicates potential therapeutic functions for increased high-density lipoprotein levels in ...
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New research firmly establishes the reverse cholesterol transport pathway, which carries cholesterol through the high-density lipoprotein, as significant in normal cholesterol homeostasis. Modulation of this pathway by transgenic and pharmacological techniques indicates potential therapeutic functions for increased high-density lipoprotein levels in ...
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An overview of reverse cholesterol transport
Atherosclerosis, 1994Reverse cholesterol transport is a multi-step process resulting in the net movement of cholesterol from peripheral tissues back to the liver via the plasma compartment. Cellular cholesterol efflux is mediated by HDL, acting in conjunction with the cholesterol esterifying enzyme, lecithin: cholesterol acyltransferase.
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Increased reverse cholesterol transport in athletes
Metabolism, 1993Proposed mechanisms for the cardioprotective benefits of exercise include decreased lipid deposition and increased reverse cholesterol transport (RCT). RCT involves the efflux of tissue free cholesterol into high-density lipoprotein (HDL) particles, esterification by lecithin:cholesterol acyltransferase (LCAT), transfer to other lipoproteins by ...
Edward A. Ross +3 more
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Molecular mechanisms of reverse cholesterol transport
Current Opinion in Lipidology, 1996The initial step of reverse cholesterol transport, the efflux of cell cholesterol into the extracellular fluid, has received much attention over the past year. Some studies have provided insights into the mechanism of cholesterol efflux and others have focused on the identity of the extracellular acceptors of cell cholesterol.
Kerry-Anne Rye, Philip J. Barter
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Reverse cholesterol transport with acute exercise
Medicine & Science in Sports & Exercise, 1993Physical activity has been shown to be inversely related to coronary heart disease (CHD). The role of high density lipoprotein (HDL) particles in the process of reverse cholesterol transport may be a link between exercise and the prevention of CHD. The aim of the present study was to evaluate the effects of acute exercise on cholesterol efflux (C-EF ...
Barbara N. Campaigne +3 more
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