Results 231 to 240 of about 663,476 (278)

CRISPR/Cas9 screens identify key host factors that enhance rotavirus reverse genetics efficacy and vaccine production. [PDF]

NPJ Vaccines
Zhu Y, Sullender ME, Campbell DE, Wang L, Lee S, Kawagishi T, Hou G, Dizdarevic A, Jais PH, Baldridge MT, Ding S.   +10 more
europepmc   +1 more source

Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley   +1 more source

Development of a robust and efficient virus-induced gene silencing system for reverse genetics in recalcitrant Camellia drupifera capsules. [PDF]

Plant Methods
Shen H, Chen H, Li W, He S, Liao B, Xiong W, Shen Y, Li Y, Gao Y, Li YQ, Zhang B.   +10 more
europepmc   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Reverse genetics construction and pathogenicity of a novel recombinant NADC30-like PRRSV isolated in China. [PDF]

Front Vet Sci
Guo J, Li C, Lu H, Wang B, Zhang L, Ding J, Jiao X, Li Q, Zhu S, Wang A, Li Y.   +10 more
europepmc   +1 more source

Evaluation of safety, immunogenicity, and efficacy of inactivated reverse-genetics-based H5N8 highly pathogenic avian influenza virus vaccine with various adjuvants via parenteral and mucosal routes in chickens. [PDF]

Front Immunol
Tabynov K, Kuanyshbek A, Yelchibayeva L, Zharmambet K, Zhumadilova Z, Fomin G, Petrovsky N, Shekoni OC, Renukaradhya GJ, Tabynov K.   +9 more
europepmc   +1 more source

Rescuing Newcastle disease virus with tag for screening viral-host interacting proteins based on highly efficient reverse genetics. [PDF]

Front Vet Sci
Wang R, Cao X, Lu K, Chang Z, Dong X, Guo H, Wei X, Dang R, Wang J, Wang X, Xiao S, Liu H, Yang Z.   +12 more
europepmc   +1 more source

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Forward in Reverse: How Reverse Genetics Complements Chemical Genetics

Pharmacogenomics, 2005
Pharmaceutical discovery has a renewed interest in physiological screening, while chemical genomics initiatives will soon provide a large amount of cellular assay data. However, there is no single robust approach to connect active compounds with their targets, limiting their experimental and therapeutic use.
openaire   +2 more sources

Genetics and reverse genetics of rotavirus

Current Opinion in Virology, 2012
Rotavirus is a member of the family Reoviridae, which have genomes consisting of 10-12 double-stranded RNA segments. The functions of proteins encoded by each segment of the rotavirus genome have been studied extensively by several methods including reassortants, temperature-sensitive mutants, isolates with rearranged RNA segments, RNAi analysis, and ...
Koki, Taniguchi, Satoshi, Komoto
openaire   +2 more sources