Results 241 to 250 of about 666,471 (318)

Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity

, 2016
M.D. Mathew, Neal D. Mathew, Angela L Miller, Simpson Mike, Vinci Au, S. Jayne Garland, Marie Gestin, Mark L. Edgley, Stéphane Flibotte, Aruna D. Balgi, Jennifer Chiang, Guri Giaever, P.M. Dean, Tung Audrey, Michel Roberge, Calvin D. Roskelley, Tom Forge, Corey Nislow, Donald G. Moerman   +18 more
openalex   +2 more sources

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Quantitative Assessment of Upper Limb Ataxia Using a Virtual Reality‐Based Evaluation System

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebellar ataxia impairs coordination and balance, reducing quality of life. Conventional clinical scales, including the Scale for the Assessment and Rating of Ataxia (SARA) and the International Cooperative Ataxia Rating Scale (ICARS), are widely used to assess ataxia but are limited by subjectivity and inter‐rater variability ...
Masayuki Sato, Takayuki Abe, Sho Aoki, Setsuki Tsukagoshi, Yasushi Yuminaka, Yoshio Ikeda   +5 more
wiley   +1 more source

Generation of an artificially attenuated fowl adenovirus 4 viral vector using the reverse genetics system based on full-length infectious clone. [PDF]

Vet Res
Tang Z, Feng D, Fan W, Yan L, Song S.
europepmc   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Efficient and robust reverse genetics system for bovine rotavirus generation and its application for antiviral screening. [PDF]

Virol Sin
Qin SK, Li KH, Liu BJ, Cao C, Yu DB, Jiang ZG, Wang J, Han YX, Wang F, Qi YL, Sun C, Yu L, Chang JT, Yin X.   +13 more
europepmc   +1 more source

Regeneration of a recombinant infectious bursal disease virus having four amino acid substitutions in VP2 by reverse genetics

, 2015
M Noor, Caroline Lüken, PM Das, MR Islam, H. Müller   +4 more
openalex   +2 more sources

Approaching genetic diseases by “reverse genetics” [PDF]

Japanese journal of human genetics, 1990
openaire   +1 more source

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu, Oliver Robinson, Christina M. Lill, Anna Matton, Raquel Puerta, Pilar Sanz, Merce Boada, Agustín Ruiz, Lefkos Middleton, for the Alzheimer's Disease Neuroimaging Initiative   +9 more
wiley   +1 more source

Development and Characterization of a New TILLING Population for Forward and Reverse Genetics in Barley (Hordeum vulgare L.). [PDF]

Plants (Basel)
Wang F, Zhu L, Zhou Z, Gu Y, Guo B, Lv C, Zhu J, Liu X, Xu R.   +8 more
europepmc   +1 more source