Results 211 to 220 of about 570,932 (356)

Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase [PDF]

, 1993
Paul L. Boyer, Michael J. Currens, James B. McMahon, Michael R. Boyd, Stephen H. Hughes   +4 more
openalex   +1 more source

YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis

Advanced Science, EarlyView.
This study identifies YTHDC1 as a key regulator of postnatal liver development and disease. Hepatocyte‐specific deletion of Ythdc1 impairs hepatocyte maturation, causing liver injury, contributing to nonalcoholic steatohepatitis and hepatocellular carcinoma.
Xinzhi Li, Xueying Li, Chunhong Liu, Zhenzhi Li, Kaixin Ding, Yuxin Wang, Ning Gu, Liwei Xie, Zheng Chen   +8 more
wiley   +1 more source

A phylogenetic analysis of the genus Leuconostoc based on reverse transcriptase sequencing of 16 S rRNA [PDF]

, 1990
Antonio Martı́nez-Murcia, Matthew Collins   +1 more
openalex   +1 more source

Single‐Droplet Dual‐Target Quantification of circRNA Biomarkers for Colorectal Cancer Screening

Advanced Science, EarlyView.
Circular RNAs are crucial in tumorigenesis. This study identifies circCK1γ3 and circWDR37 as dual plasma biomarkers for colorectal cancer (CRC) screening. It is developed Casµchip, a droplet microfluidic chip using Cas13a/b technology to quantify these biomarkers.
Jingsong Xu, Yu Liu, Junheng Zhang, Shuang Yang, Tianming Li, Haiqian Huang, Qian Liu, Hengliang Wang, Li Cao, Zhenghua An, Min Li, Hua Wang   +11 more
wiley   +1 more source

Reverse transcriptase inhibitors in Aicardi-Goutières syndrome: A crossover clinical trial. [PDF]

Dev Med Child Neurol
Crow YJ, Briggs TA, Eleftheriou D, Parida A, Battison C, Giddings A, Kennel T, Parker RA, AGS‐RTIs Study Group.   +8 more
europepmc   +1 more source

A Phase Separation‐Assisted Pre‐Enrichment Method for Ultrasensitive Respiratory Virus Detection

Advanced Science, EarlyView.
Conventional biomarker enrichment lacks versatility and specificity. Phase separation‐assisted pre‐enrichment (PSAP) is introduced for concurrent antigen (47×) and RNA (44×) enrichment. Tenfold and fivefold lower detection limits for SARS‐CoV‐2 and Influenza, respectively, were achieved.
Yang Cao, Pui Ngan Lau, Alex W.H. Chin, Zhuolin He, Christina C. K. Au Yeung, Kehao Zeng, Haisong Lin, Leo L. M. Poon, Ho Cheung Shum   +8 more
wiley   +1 more source

Novel effects of reverse transcriptase inhibitor supplementation in skeletal muscle of old mice. [PDF]

Physiol Genomics
Osburn SC, Smith ME, Wahl D, LaRocca TJ.
europepmc   +1 more source

Abortive reverse transcription by mutants of Moloney murine leukemia virus deficient in the reverse transcriptase-associated RNase H function [PDF]

, 1991
Naoko Tanese, Alice Telesnitsky, Stephen P. Goff   +2 more
openalex   +1 more source

ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors

Advanced Science, EarlyView.
This study unveils that ACSS2‐driven acetate metabolism fuels histone pan‐acetylation in pancreatic neuroendocrine tumors (PNETs), remodeling the epigenetic landscape. The ACSS2/AATF axis transcriptionally activates soluble FasL (sFasL), which engages Fas receptors on infiltrating CD8+ T cells to trigger caspase‐8/3‐mediated apoptosis.
Qin Dang, Ting Wang, Yan Wang, Zeng Ye, Borui Li, Xuan Pan, Zheng Li, Guixiong Fan, Desheng Jing, Junfeng Xu, Qiangsheng Hu, Shunrong Ji, Xiaowu Xu, Xianjun Yu, Yi Qin   +14 more
wiley   +1 more source

Reverse transcriptase activity in psoriatic lesions: effects of reverse transcriptase inhibitors on keratinocyte proliferation and differentiation

Retrovirology, 2009
Bonté Frédéric, Dumas Marc, Tesniere Anne, Molès Jean-Pierre, Guilhou J-J   +4 more
doaj   +1 more source