Results 191 to 200 of about 125,916 (291)

Development of fluorine-substituted NH₂-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors: Boosting the safety and metabolic stability. [PDF]

Acta Pharm Sin B, 2023
Jin X, Wang S, Zhao L, Huang W, Zhang Y, Pannecouque C, De Clercq E, Meng G, Piao H, Chen F.   +9 more
europepmc   +1 more source

Synthesis, biological activity and docking study of imidazol-5-one as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

, 2012
Santosh N. Mokale, Deepak K. Lokwani, Devanand B. Shinde   +2 more
openalex   +1 more source

In Vivo, Nucleoside Reverse‐Transcriptase Inhibitors Alter Expression of Both Mitochondrial and Lipid Metabolism Genes in the Absence of Depletion of Mitochondrial DNA [PDF]

, 2005
Patrick Mallon, Patrick Unemori, Rebecca Sedwell, Adrienne Morey, Martina Rafferty, Kenneth Williams, Donald J. Chisholm, Katherine Samaras, Sean Emery, Anthony D. Kelleher, David A. Cooper, Andrew Carr, SAMA Investigators   +12 more
openalex   +1 more source

Protein turnover downstream of the Nipbl/CRL4 axis contributes to abnormal development in zebrafish embryos

Developmental Dynamics, EarlyView.
Abstract Background Mutations in cohesins cause cohesinopathies such as Cornelia de Lange Syndrome (CdLS) and Roberts Syndrome (RBS). Prior findings demonstrate that Esco2 (a cohesin activator) and Smc3 (a core cohesin subunit) regulate the CRL4 E3 ubiquitin ligase. SMC3 mutations, however, account for a small percentage of CdLS.
Annie C. Sanchez, Niusha Banoukh, Fiona Mensching, Robert V. Skibbens, M. Kathryn Iovine   +4 more
wiley   +1 more source

High prevalence of reverse transcriptase inhibitors associated resistance mutations among people living with HIV on dolutegravir-based antiretroviral therapy in Francistown, Botswana. [PDF]

J Antimicrob Chemother
Choga OT, Lemogang GM, Choga WT, Muzanywa G, Shadreck TM, Ralegoreng C, Maruapula D, Moraka NO, Koofhethile CK, Mokgethi PT, Seru K, Zuze BJL, Montshosi P, Gobe I, Motswaledi MS, Musonda R, Mbulawa MB, Makhema J, Shapiro R, Lockman S, Chebani T, Nawa J, Bochena L, Moyo S, Gaseitsiwe S.   +24 more
europepmc   +1 more source

Islatravir Has a High Barrier to Resistance and Exhibits a Differentiated Resistance Profile from Approved Nucleoside Reverse Transcriptase Inhibitors (NRTIs). [PDF]

Antimicrob Agents Chemother, 2022
Diamond TL, Ngo W, Xu M, Goh SL, Rodriguez S, Lai MT, Asante-Appiah E, Grobler JA.   +7 more
europepmc   +1 more source

Impact of Minority Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutations on Resistance Genotype After Virologic Failure [PDF]

, 2012
Jonathan Z. Li, Roger Paredes, Heather J. Ribaudo, Michael J. Kozal, Evguenia S. Svarovskaia, Jeffrey A. Johnson, Anna María Geretti, Karin J. Metzner, Martin R. Jakobsen, Katherine Huppler Hullsiek, Lars Østergaard, Michael D. Miller, Daniel R. Kuritzkes   +12 more
openalex   +1 more source

Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts

Developmental Dynamics, EarlyView.
Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore, Anjali Balakrishnan, Yacine Touahri, Dawn Zinyk, Humna Noman, Satoshi Okawa, Jeff Biernaskie, Carol Schuurmans   +7 more
wiley   +1 more source

No accelerated progression of subclinical atherosclerosis with integrase strand transfer inhibitors compared to non-nucleoside reverse transcriptase inhibitors. [PDF]

J Antimicrob Chemother
García-Abellán J, García JA, Padilla S, Fernández-González M, Agulló V, Mascarell P, Botella Á, Gutiérrez F, Masiá M.   +8 more
europepmc   +1 more source

Synthesis and anti-HIV activities of urea-pETT analogs belonging to a new class of potent non-nucleoside HIV-1 Reverse transcriptase inhibitors

, 1998
Christer Sahlberg, Rolf Noréen, Per Engelhardt, Marita Högberg, Jussi Kangasmetsä, Lotta Vrang, Hong Zhang   +6 more
openalex   +1 more source