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Initiation of HIV Reverse Transcription
Viruses, 2010 Reverse transcription of retroviral genomes into double stranded DNA is a key event for viral replication. The very first stage of HIV reverse transcription, the initiation step, involves viral and cellular partners that are selectively packaged into the
Roland Marquet +2 more
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Reverse transcription progression and genome length regulate HIV-1 core elasticity and disassembly. [PDF]
PLoS PathogensThe structural and mechanical properties of the HIV-1 core are critical for successful infection, balancing stability for early replication and controlled disassembly for genome release.
Akshay Deshpande +4 more
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HIV-1 capsid stability and reverse transcription are finely balanced to minimize sensing of reverse transcription products via the cGAS-STING pathway [PDF]
mBioA critical determinant for early post-entry events, the HIV-1 capsid (CA) protein forms the conical core when it rearranges around the dimeric RNA genome and associated viral proteins.
Jenna E. Eschbach +7 more
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Development and Evaluation of Real-Time Reverse Transcription Polymerase Chain Reaction Test for Quantitative and Qualitative Recognition of H5 Subtype of Avian Influenza Viruses [PDF]
Archives of Razi Institute, 2020 Avian influenza viruses (AIV) affect a wide range of birds and mammals, cause severe economic damage to the poultry industry, and pose a serious threat to humans.
S.G. Mirzaei, A. Shoushtari, A. Noori
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Epidemiological and molecular study of Rotavirus infection among human and animal in Karbala and Basrah provinces [PDF]
Iraqi Journal of Veterinary Sciences, 2021 This study was aimed to determine the prevalence of rotaviruses in Karbala and Basrah provinces, the genetic reassortment of human and animal rotavirus strains and the novel strains.
Faten K. Aldawmy +2 more
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The HIV-1 capsid and reverse transcription
Retrovirology, 2021 The viral capsid plays a key role in HIV-1 reverse transcription. Recent studies have demonstrated that the small molecule IP6 dramatically enhances reverse transcription in vitro by stabilizing the viral capsid.
Christopher Aiken, Itay Rousso
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Journal of Infection in Developing Countries, 2022 Introduction: Accurate detection of severe acute respiratory syndrome coronavirus 2 is critical for diagnosis and disease status evaluation of Coronavirus disease 2019.
Renfei Lu +6 more
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mBio, 2020 A defining activity of retroviruses is reverse transcription, the process by which the viral genomic RNA is converted into the double-stranded DNA required for virus replication.
Jordan Jennings +4 more
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HIV-1 Reverse Transcription [PDF]
, 2014 Reverse transcription is an obligatory step in retrovirus replication in the course of which the retroviral RNA/DNA-dependent DNA polymerase (RT) copies the single-stranded positive sense RNA genome to synthesize the double-stranded viral DNA. At the same time the RT-associated RNaseH activity degrades the genomic RNA template, which has just been ...
Cimarelli, Andrea, Darlix, Jean-Luc
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HIV-1 Reverse Transcription [PDF]
Cold Spring Harbor Perspectives in Medicine, 2012 Reverse transcription and integration are the defining features of the Retroviridae; the common name "retrovirus" derives from the fact that these viruses use a virally encoded enzyme, reverse transcriptase (RT), to convert their RNA genomes into DNA. Reverse transcription is an essential step in retroviral replication.
Wei-Shau, Hu, Stephen H, Hughes
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