Results 101 to 110 of about 1,341 (183)

Virulence and resistance factors of Nakaseomyces glabratus (formerly known as Candida glabrata) in Europe: A systematic review

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 2, Page 377-388, February 2025.
Nakaseomyces glabratus (formerly known as Candida glabrata) is an endogenous opportunistic pathogen that causes various clinical manifestations, ranging from mucocutaneous overgrowth to bloodstream infections. This review aims to summarize the biology, epidemiology and pathology of N.
Carmen Rodríguez‐Cerdeira, Rodolfo Pinto‐Almazán, Ditte M. L. Saunte, R. Hay, Jacek C. Szepietowski, Gabriela Moreno‐Coutiño, Mihael Skerlev, Asja Prohic, Erick Martínez‐Herrera   +8 more
wiley   +1 more source

EUCAST Reference Testing of Rezafungin Susceptibility and Impact of Choice of Plastic Plates [PDF]

Antimicrobial Agents and Chemotherapy, 2019
Rezafungin is a new long-acting echinocandin currently in phase 3 development. Epidemiological cutoff values are necessary for breakpoint setting but have not been established due to unexplained interlaboratory MIC variations observed in a prior multicenter study.
Maiken Cavling Arendrup, Karin Meinike Jørgensen, Rasmus Krøger Hare, Manuel Cuenca-Estrella, Oscar Zaragoza   +4 more
openaire   +3 more sources

Lactams Exhibit Potent Antifungal Activity Against Monospecies and Multispecies Interkingdom Biofilms on a Novel Hydrogel Skin Model

APMIS, Volume 133, Issue 1, January 2025.
ABSTRACT Infections of intact and damaged skin barriers and keratin are frequently associated with complex biofilm communities containing bacteria and fungi, yet there are limited options for successful management. This study intended to focus on the utility of some novel proprietary lactam molecules, quorum sensing (QS)–derived halogenated furanones ...
Hafsa Abduljalil, Om Alkhir Alshanta, Safa Chougule, Mark Butcher, Bryn Short, William McLean, Neil Parry, Joanne O'Keeffe, Gordon Ramage   +8 more
wiley   +1 more source

Multidrug resistance mechanisms and therapeutic strategies in Candida auris [PDF]

In recent years, Candida auris has emerged as a formidable global health threat due to its multidrug resistance, high transmissibility in healthcare settings, and diagnostic challenges. Unlike most Candida species, C. auris can colonize the skin, persist
Alkaabi, Sara
core   +2 more sources

Exploring the Depths of Cryptic Aspergillosis: Species Variability, Clinical Spectrum, Diagnostic Quandaries and Therapeutic Options [PDF]

Journal of Clinical and Diagnostic Research
Cryptic aspergillosis, characterised by infections caused by non classical Aspergillus species, presents unique challenges in clinical management due to species variability, diverse clinical manifestations, diagnostic complexities, and limited treatment ...
Almas Fathima Upaisal, Anupma Jyoti Kindo   +1 more
doaj   +1 more source

The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies

Chemical Biology &Drug Design, Volume 105, Issue 1, January 2025.
The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates.
Cengiz Zobi, Oztekin Algul
wiley   +1 more source

The Candida auris Infection After the COVID‐19 Pandemic Seems to be an Urgent Public Health Emergency: A Call to Attention

Health Science Reports, Volume 7, Issue 11, November 2024.
Abstract Background and Aims Inconsequential diseases can sometimes become extremely dangerous through mutation. Antifungal resistance has increased by 24%, and resistance only due to Candida auris (C. auris) species have increased by 60%. Here, we aimed to assess the knowledge of antifungal treatment and preventative measures to mitigate the ...
Md. Ashrafur Rahman, Evangelos Victoros, Yeasna Shanjana, Marie Roke Thomas, Md. Rabiul Islam   +4 more
wiley   +1 more source

Fungal lung disease. [PDF]

Fungal lung disease encompasses a wide spectrum of organisms and associated clinical conditions, presenting a significant global health challenge. The type and severity of disease are determined by underlying host immunity and infecting fungal strain ...
Agarwal, Ritesh, Chotirmall, Sanjay, Delhaes, Laurence, Hage, Chadi, Jaggi, Tavleen, Langelier, Charles, Lydon, Emily, Shah, Anand, Tiew, Pei, Waterer, Grant   +9 more
core   +1 more source

Novel drugs approved by the EMA, the FDA, and the MHRA in 2023: A year in review

British Journal of Pharmacology, Volume 181, Issue 11, Page 1553-1575, June 2024.
Abstract In 2023, seventy novel drugs received market authorization for the first time in either Europe (by the EMA and the MHRA) or in the United States (by the FDA). Confirming a steady recent trend, more than half of these drugs target rare diseases or intractable forms of cancer.
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam Cortese‐Krott, Dave A. Kendall, Kirill A. Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Mauro M. Teixeira, Nathalie Vergnolle, Xin Wang, Péter Ferdinandy   +16 more
wiley   +1 more source

What is the role of microbial biotechnology and genetic engineering in medicine?

MicrobiologyOpen, Volume 13, Issue 2, April 2024.
Microbial biotechnology, the technological application of microorganisms, has been instrumental in producing significant natural bioactive products. These include antibiotics, antifungals, anticancer drugs, antiparasitics, antivirals, immunosuppressants, toxoid vaccines, and therapeutic enzymes.
Fernando Santos‐Beneit
wiley   +1 more source