Results 71 to 80 of about 1,141 (182)

Lack of Effect of Rezafungin on QT/QTc Interval in Healthy Subjects [PDF]

Clinical Pharmacology in Drug Development, 2019
AbstractRezafungin is a new echinocandin in development for treatment of candidemia and invasive candidiasis, and for prophylaxis of invasive fungal infections. Rezafungin is the first echinocandin to undergo definitive QT/QTc study. This phase 1, single‐center, randomized, double‐blind trial was conducted to assess effects of intravenous rezafungin vs
Shawn, Flanagan, Daniel B, Goodman, Alena, Jandourek, Terry, O'Reilly, Taylor, Sandison   +4 more
openaire   +2 more sources

Valutazione dei fattori di rischio per lo sviluppo di candidemia dopo interventi di cardiochirurgia maggiore [PDF]

, 2020
Background: Candida species are among the most frequent causative agents of healthcare-associated bloodstream infections, with mortality higher than 40% in critically ill patients. Specific populations of critically ill patients may present peculiar risk
Giacobbe, Daniele Roberto
core   +1 more source

Acute Lymphoblastic Leukemia and Invasive Mold Infections: A Challenging Field

Journal of Fungi, 2022
Acute lymphoblastic leukemia (ALL) patients comprise a highly immunocompromised group due to factors associated either with the treatment or the disease itself.
Christos Stafylidis, Panagiotis Diamantopoulos, Eleni Athanasoula, Elena Solomou, Amalia Anastasopoulou   +4 more
doaj   +1 more source

In Vitro Activitiy of Rezafungin in Comparison with Anidulafungin and Caspofungin against Invasive Fungal Isolates (2017 to 2022) in China

Journal of Fungi
The efficacy of different echinocandins is assessed by evaluating the in vitro activity of a novel antifungal, rezafungin, against invasive fungal isolates in comparison with anidulafungin and caspofungin.
Simin Yang, Feifei Wan, Min Zhang, Huiping Lin, Liang Hu, Ziyi Zhou, Dongjiang Wang, Aiping Zhou, Lijun Ni, Jian Guo, Wenjuan Wu   +10 more
doaj   +1 more source

Hope on the horizon: Novel fungal treatments in development [PDF]

, 2020
The treatment of invasive fungal infections remains challenging due to limitations in currently available antifungal therapies including toxicity, interactions, restricted routes of administration, and drug resistance.
Coler-Reilly, Ariella, Larson, Lindsey, Rauseo, Adriana M, Spec, Andrej   +3 more
core   +1 more source

Antifungal Resistance of Candida spp. Isolates From HIV/AIDS Patients in Iran 1999–2024: A Systematic Review and Meta‐Analysis

Journal of Clinical Laboratory Analysis, Volume 39, Issue 21, November 2025.
Antimicrobial resistance in Candida spp. is significant in individuals with HIV/AIDS infections, particularly in Iran. In this systematic review, a comprehensive systematic search was conducted to identify all the eligible studies between 1999 and 2024; the pooled resistance rates of Candida spp. against antimicrobial agents were estimated. The risk of
Aliasghar Fakhri‐Demeshghieh, Ali Yousefipour, Yousef Bolouki, Mohammad Sadegh Bigdeli, Erfan Zamani, Amirreza Farajkhoda, Alireza Salmani, Farzad Katiraee, Saied Bokaie   +8 more
wiley   +1 more source

Multicentre determination of rezafungin (CD101) susceptibility of Candida species by the EUCAST method [PDF]

Clinical Microbiology and Infection, 2018
Rezafungin (CD101) is a new long-acting echinocandin allowing weekly dosing, currently undergoing phase-II clinical trials for invasive candidiasis. The aim of this study was to assess rezafungin's in vitro activity against the most frequent Candida species following the EUCAST methodology.The susceptibility of 2018 clinical Candida isolates was ...
Arendrup, M. C., Meletiadis, J., Zaragoza, O., Jørgensen, K. M., Marcos-Zambrano, L. J., Kanioura, L., Cuenca-Estrella, M., Mouton, J. W., Guinea, J.   +8 more
openaire   +4 more sources

Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs

European Journal of Organic Chemistry, Volume 28, Issue 38, October 15, 2025.
Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar, Perla Islas‐Jácome, Leonardo D. Herrera‐Zuñiga, Samuel Couve‐Bonnaire, Philippe Jubault, Eduardo González‐Zamora, Jean‐Philippe Bouillon, Alejandro Islas‐Jácome   +7 more
wiley   +1 more source

In vitro activity of rezafungin against common and rare Candida species and Saccharomyces cerevisiae [PDF]

Journal of Antimicrobial Chemotherapy, 2019
AbstractBackgroundRezafungin is a novel echinocandin with excellent activity against common Candida species; however, limited data are available regarding rare Candida species.MethodsWe determined the in vitro susceptibility of 689 clinical isolates of 5 common and 19 rare Candida species, as well as Saccharomyces cerevisiae. The activity of rezafungin
Tóth, Zoltán, Forgács, Lajos, Locke, Jeffrey B, Kardos, Gábor, Nagy, Fruzsina, Kovács, Renátó, Szekely, Adrien, Borman, Andrew M, Majoros, László   +8 more
openaire   +2 more sources

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, Volume 12, Issue 37, October 6, 2025.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source