Results 71 to 80 of about 51,297 (183)

The Supporting Role of Natural Products as Effective Adjuvants in Cancer Immunotherapy

eFood, Volume 7, Issue 3, June 2026.
Natural products, as multi‐target and low‐toxicity adjuvants, enhance immune checkpoint inhibitor responses and reduce immune‐related adverse events through T cell reprogramming, microenvironment remodeling, and microbiota‐immune modulation. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of malignant tumors ...
Boyang Liu, Yubin Huang, Jianjun Deng, Zhijun Mao, Xue Bai, Longyang Ma, Jianhua Wang   +6 more
wiley   +1 more source

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source

Bottom‐Up Assembly of Amorphous Metal–Organic Frameworks From Proton Conductive Metal–Organic Polyhedra

Small, Volume 22, Issue 36, 26 June 2026.
Structural control in amorphous MOFs (aMOFs) remains challenging compared to their crystalline counterparts. We report a bottom‐up strategy using metal‐organic polyhedra as predefined building units. By crosslinking these clusters, we preserve intrinsic node functionality within aMOFs, achieving proton conductivity up to 4.8 mS cm−1 at 85°C and 90% RH,
Nattapol Ma, Daiki Umeyama, Hiroki Yamada, Soracha Kosasang   +3 more
wiley   +1 more source

OsFKBP20‐1b stabilizes OsUPF1 and OsUPF2 to promote the degradation of aberrant mRNAs during dehydration stress

Journal of Integrative Plant Biology, Volume 68, Issue 6, Page 1672-1691, June 2026.
The rice protein OsFKBP20‐1b protects key RNA‐surveillance factors from breakdown, so they can better eliminate defective messages. This RNA quality‐control boost reduces errors and helps plants survive drought, revealing a link between RNA control and drought tolerance.
Haemyeong Jung, Hyun Ji Park, Seung Hee Jo, Ki‐Hong Jung, Choonkyun Jung, Hye Sun Cho   +5 more
wiley   +1 more source

Assessment of a New Ginsenoside Rh2 Nanoniosomal Formulation for Enhanced Antitumor Efficacy on Prostate Cancer: An in vitro Study

Drug Design, Development and Therapy, 2020
Hadi Zare-Zardini,1– 3 Ashraf Alemi,4 Asghar Taheri-Kafrani,5 Seyed Ahmad Hosseini,6 Hossein Soltaninejad,7,8 Amir Ali Hamidieh,9 Mojtaba Haghi Karamallah,10 Majid Farrokhifar,11 Mohammad Farrokhifar12 1Hematology and Oncology Research Center ...
Zare-Zardini H, Alemi A, Taheri-Kafrani A, Hosseini SA, Soltaninejad H, Hamidieh AA, Haghi Karamallah M, Farrokhifar M, Farrokhifar M   +8 more
doaj  

Langerhans cell-like dendritic cells treated with ginsenoside Rh2 regulate the differentiation of Th1 and Th2 cells in vivo

Open Chemistry, 2019
Ginsenoside Rh2 is one of the rare ginsenosides extracted from Panax ginseng C. A. Mey. The anti-allergic activity of ginsenoside Rh2 has been documented in some literature.
Liu Ying, Wu Qian, Li Peng, Liu Weijie, Jin Yongri, Li Xuwen, Shi Xiaolei   +6 more
doaj   +1 more source

20(S)-Ginsenoside Rh2 inhibits hepatocellular carcinoma by suppressing angiogenesis and the GPC3‐mediated Wnt/β‑catenin signaling pathway

Acta Biochimica et Biophysica Sinica
20(S)-Ginsenoside Rh2 has significant anti-tumor effects in various types of cancers, including human hepatocellular carcinoma (HCC). However, its molecular targets and mechanisms of action remain largely unknown.
Xu Linfei, Li Jing, Hou Ningning, Han Fang, Sun Xiaodong, Li Qinying   +5 more
doaj   +1 more source

Ginsenoside Rh2 shifts tumor metabolism from aerobic glycolysis to oxidative phosphorylation through regulating the HIF1-α/PDK4 axis in non-small cell lung cancer

Molecular Medicine
Background Ginsenoside Rh2 (G-Rh2), a steroidal compound extracted from roots of ginseng, has been extensively studied in tumor therapy. However, its specific regulatory mechanism in non-small cell lung cancer (NSCLC) is not well understood.
Xiyu Liu, Jingjing Li, Qingqing Huang, Mingming Jin, Gang Huang   +4 more
doaj   +1 more source

Ginsenoside Rh2 alleviates inflammatory response and enhances motor function recovery in spinal cord injury mice via the ROS/MAPK14 signaling pathway

Journal of Ginseng Research
Background: Inhibiting inflammation in nervous system is a vital part of treating for spinal cord injury (SCI). Compounds originating from plants can decrease the damage in the spinal cord for recovering the function of nerve and interrupting the ...
Yanlan Wu, Fangming Song, Xiuwei Tan, Jin Huang, Junliang Lu, Baihui Yang, Fang Fang, Xiaoxia Ye, Laoyi Geer, Fengxin Li, Qian Wei, Xuefeng Lu, Jiake Xu, Jie Jiang, Yiji Su   +14 more
doaj   +1 more source

20(S)-Ginsenoside Rh2 overcomes gemcitabine resistance in pancreatic cancer by inhibiting LAMC2-Modulated ABC transporters

Journal of Advanced Research
Introduction: Gemcitabine (GEM) is the first-line drug for pancreatic ductal adenocarcinoma (PDAC), but drug resistance severely restricts its chemotherapeutic efficacy. Laminin subunit γ2 (LAMC2) plays a crucial role in extracellular matrix formation in
Yulin Wu, Juan Zhang, Yuanyang Tian, William Chi Shing Cho, Hong-Xi Xu, Zhi-Xiu Lin, Yan-Fang Xian   +6 more
doaj   +1 more source