Results 1 to 10 of about 57,806 (244)
Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts [PDF]
Arthritis Research & Therapy, 2005 AbstractRho is a major small GTP-binding protein that is involved in the regulation of various cell functions, including proliferation and cell migration, through activation of multiple signaling molecules in various types of cells. We studied its roles in synovial fibroblasts (SFs) in patients with rheumatoid arthritis (RA) and clarified its relevance
Shingo Nakayamada +4 more
core +7 more sources
Flux Analysis in Process Models via Causality [PDF]
Electronic Proceedings in Theoretical Computer Science, 2010 We present an approach for flux analysis in process algebra models of biological systems. We perceive flux as the flow of resources in stochastic simulations. We resort to an established correspondence between event structures, a broadly recognised model
Ozan Kahramanoğulları
doaj +4 more sources
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton [PDF]
The EMBO Journal, 1999 Soluble factors from serum such as lysophosphatidic acid (LPA) are thought to activate the small GTP-binding protein Rho based on their ability to induce actin stress fibers and focal adhesions in a Rho-dependent manner. Cell adhesion to extracellular matrices (ECM) has also been proposed to activate Rho, but this point has been controversial due to ...
Xiang-Dong Ren
openalex +4 more sources
Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family. [PDF]
Proceedings of the National Academy of Sciences, 1995 Philadelphia chromosome-positive leukemias result from the fusion of the BCR and ABL genes, which generates a functional chimeric molecule. The Abr protein is very similar to Bcr but lacks a structural domain which may influence its biological regulatory capabilities. Both Abr and Bcr have a GTPase-activating protein (GAP) domain similar to those found
Tsung‐Hsien Chuang +5 more
openalex +4 more sources
Involvement of the GTP binding protein Rho in constitutive endocytosis in Xenopus laevis oocytes. [PDF]
The Journal of cell biology, 1995 To study an endocytotic role of the GTP-binding protein RhoA in Xenopus oocytes, we have monitored changes in the surface expression of sodium pumps, the surface area of the oocyte and the uptake of the fluid-phase marker inulin. Xenopus oocytes possess intracellular sodium pumps that are continuously exchanged for surface sodium pumps by constitutive ...
Günther Schmalzing +5 more
openalex +4 more sources
Signal transduction through the GTP-binding proteins Rac and Rho [PDF]
Journal of Cell Science, 1994 ABSTRACT Actin reorganization is an early response to many extra- cellular factors. In Swiss 3T3 fibroblasts, the Ras-related GTP-binding proteins Rho and Rac act as key signal trans- ducers in these responses: Rho is required for growth factor-induced formation of stress fibres and focal adhesions, whereas membrane ruffling is regulated
Anne J. Ridley
openalex +3 more sources
A Process Model of Rho GTP-binding Proteins in the Context of Phagocytosis
Electronic Notes in Theoretical Computer Science, 2008 AbstractAt the early stages of the phagocytic signalling, Rho GTP-binding proteins play a key role. With the stimulus from the cell membrane and with the help from the regulators (GEF, GAP, Effector, GDI), these proteins serve as switches that interact with their environment in a complex manner.
Luca Cardelli +2 more
openalex +2 more sources
The GTP binding proteins Gem and Rad are negative regulators of the Rho–Rho kinase pathway [PDF]
The Journal of Cell Biology, 2002 The cytoskeletal changes that alter cellular morphogenesis and motility depend upon a complex interplay among molecules that regulate actin, myosin, and other cytoskeletal components. The Rho family of GTP binding proteins are important upstream mediators of cytoskeletal organization.
Yvona Ward +6 more
openalex +3 more sources
Direct Involvement of the Small GTP-binding Protein Rho in lbc Oncogene Function [PDF]
Journal of Biological Chemistry, 1995 The lbc oncogene is tumorigenic in nude mice, transforms NIH 3T3 fibroblasts, and encodes a Dbl homology domain found in several transforming gene products including the dbl oncogene product. While both lbc- and dbl-transformed NIH 3T3 foci exhibited a comparable gross appearance, lbc-transformed cell morphology was clearly distinct from that of dbl ...
Yi Zheng +4 more
openalex +4 more sources
Interaction of recombinant rho A GTP‐binding proteins with photoexcited rhodopsin [PDF]
FEBS Letters, 1990 The small molecular mass GTP‐binding proteins rho A, B and C are targets for ADP‐ribosyltransferase activity of the botulinum exoenzyme C3. The possible interaction of recombinant rho A proteins expressed in E. coli with photoexcited rhodopsin was studied by reconstitution with bovine rod outer segment (ROS) membranes depleted of endogenous GTP‐binding
Thomas Wieland +5 more
openalex +4 more sources