Results 11 to 20 of about 57,806 (244)
The Small GTP-binding Protein Rho Regulates Cortical Activities in Cultured Cells during Division [PDF]
The Journal of Cell Biology, 1999 We have investigated the role of the small GTP-binding protein Rho in cytokinesis by microinjecting an inhibitor, C3 ribosyltransferase, into cultured cells. Microinjection of C3 into prometaphase or metaphase normal rat kidney epithelial cells induced immediate and global cortical movement of actin toward the metaphase plate, without an apparent ...
Christopher B. O’Connell +3 more
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Clostridium difficile toxin B acts on the GTP-binding protein Rho.
Journal of Biological Chemistry, 1994 Clostridium difficile toxin B exhibits cytotoxic activity that is characterized by the disruption of the microfilamental cytoskeleton. Here we studied whether the GTP-binding Rho protein, which reportedly participates in the regulation of the actin cytoskeleton, is involved in the toxin action. Toxin B treatment of Chinese hamster ovary cells reveals a
Ingo Just +7 more
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Signaling Pathways Controlled by Rho Family GTP-Binding Proteins
, 2000 The current Rho family picture contains 11 mammalian members, which can be subdivided into five groups on the basis of sequence and functional differences: (1) RhoA, RhoB, and RhoC; (2) Rac1, Rac2, and RhoG; (3) Cdc42 and TC10; (4) RhoD; and (5) RhoE and TTF (1,2).
Marc Symons
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Bacterial toxins and the Rho GTP-binding protein: what microbes teach us about cell regulation [PDF]
Cell Death & Differentiation, 1998 In the present review activities of two bacterial toxins, Clostridium botulinum exoenzyme C3 and Escherichia coli CNF1, both acting on the GTP-binding protein Rho are analyzed. Proteins belonging to the Rho family regulate the actin cytoskeleton and act as molecular switches in a number of signal transduction pathways. C3 and CNF1 have opposite effects
Carla Fiorentini +3 more
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Turning Platelets Off and On: Role of RhoGAPs and RhoGEFs in Platelet Activity
Frontiers in Cardiovascular Medicine, 2022 Platelet cytoskeletal reorganisation is a critical component of platelet activation and thrombus formation in haemostasis. The Rho GTPases RhoA, Rac1 and Cdc42 are the primary drivers in the dynamic reorganisation process, leading to the development of ...
Shane P. Comer, Shane P. Comer
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