Results 11 to 20 of about 82,160 (288)

GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo [PDF]

BioEssays, 2007
AbstractRho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is currently known that these GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. In this review, we will
Xosé R. Bustelo, Vincent Sauzeau, Inmaculada M. Berenjeno   +2 more
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Involvement of the GTP binding protein Rho in constitutive endocytosis in Xenopus laevis oocytes. [PDF]

The Journal of cell biology, 1995
To study an endocytotic role of the GTP-binding protein RhoA in Xenopus oocytes, we have monitored changes in the surface expression of sodium pumps, the surface area of the oocyte and the uptake of the fluid-phase marker inulin. Xenopus oocytes possess intracellular sodium pumps that are continuously exchanged for surface sodium pumps by constitutive ...
Günther Schmalzing, Hans‐Peter Richter, Anders Holmgaard Hansen, Wolfgang H. Schwarz, Ingo Just, Klaus Aktories   +5 more
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Augmentation of human leukemic cell invasion by activation of a small GTP-binding protein Rho [PDF]

Experimental Hematology, 2000
The functions of a small GTP-binding protein, Rho, in human leukemic cell invasion was investigated in vivo and in vitro.Human leukemic KM3 and Reh cells (derived from B-cell-type common acute lymphoid leukemias) were inoculated into severe combined immundeficiency (SCID) mice.
Sachiko Fukushima, Taketo Yamada, Akinori Hashiguchi, Yuji Nakata, Junichi Hata   +4 more
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Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family. [PDF]

Proceedings of the National Academy of Sciences, 1995
Philadelphia chromosome-positive leukemias result from the fusion of the BCR and ABL genes, which generates a functional chimeric molecule. The Abr protein is very similar to Bcr but lacks a structural domain which may influence its biological regulatory capabilities. Both Abr and Bcr have a GTPase-activating protein (GAP) domain similar to those found
Tsung‐Hsien Chuang, Xuemin Xu, Vesa Kaartinen, Nora Heisterkamp, John Groffen, Gary Bokoch   +5 more
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Clostridium difficile toxin B acts on the GTP-binding protein Rho.

Journal of Biological Chemistry, 1994
Clostridium difficile toxin B exhibits cytotoxic activity that is characterized by the disruption of the microfilamental cytoskeleton. Here we studied whether the GTP-binding Rho protein, which reportedly participates in the regulation of the actin cytoskeleton, is involved in the toxin action. Toxin B treatment of Chinese hamster ovary cells reveals a
Ingo Just, Gerhard Fritz, Klaus Aktories, Murielle Giry, Michel R. Popoff, Patrice Boquet, Silke Hegenbarth, C. von Eichel-Streiber   +7 more
openalex   +4 more sources

Genome-wide identification and analysis of Rop GTPase family members reveal their potential functions in biotic stress in potato (Solanum tuberosum L.) [PDF]

BMC Plant Biology
Background Rop (RHO of plants) proteins are the plant-specific subfamily of RHO small GTP-binding proteins and act as a molecular switch to converge on a wide range of upstream signals and elicit downstream signaling cascades involving in modulating ...
Zhida Liu, Guochao Xuanyuan, Shuqing Yang, Miru Du, Xiaoluo Zhang, Tingting Bao, Zhiwei Zhang, Wenbing Zhang, Jun Zhao   +8 more
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Turning Platelets Off and On: Role of RhoGAPs and RhoGEFs in Platelet Activity

Frontiers in Cardiovascular Medicine, 2022
Platelet cytoskeletal reorganisation is a critical component of platelet activation and thrombus formation in haemostasis. The Rho GTPases RhoA, Rac1 and Cdc42 are the primary drivers in the dynamic reorganisation process, leading to the development of ...
Shane P. Comer, Shane P. Comer
doaj   +1 more source

Rho GTPases as Key Molecular Players within Intestinal Mucosa and GI Diseases

Cells, 2021
Rho proteins operate as key regulators of the cytoskeleton, cell morphology and trafficking. Acting as molecular switches, the function of Rho GTPases is determined by guanosine triphosphate (GTP)/guanosine diphosphate (GDP) exchange and their lipidation
Rashmita Pradhan, Phuong A. Ngo, Luz d. C. Martínez-Sánchez, Markus F. Neurath, Rocío López-Posadas   +4 more
doaj   +1 more source

Thrombopoietin and collagen in low doses cooperatively induce human platelet activation

Acute Medicine & Surgery, 2022
Aim In acute medicine, we occasionally treat life‐threatening conditions such as sepsis and trauma, which cause severe thrombocytopenia. Serum thrombopoietin levels have been reported to increase under the condition of thrombocytopenia related to ...
Tomoaki Doi, Takamitsu Hori, Takashi Onuma, Daisuke Mizutani, Kyohei Ueda, Yukiko Enomoto, Rie Matsushima‐Nishiwaki, Kumiko Tanabe, Tomoyuki Hioki, Haruhiko Tokuda, Toru Iwama, Hiroki Iida, Osamu Kozawa, Shinji Ogura   +13 more
doaj   +1 more source

Interaction of recombinant rho A GTP‐binding proteins with photoexcited rhodopsin [PDF]

FEBS Letters, 1990
The small molecular mass GTP‐binding proteins rho A, B and C are targets for ADP‐ribosyltransferase activity of the botulinum exoenzyme C3. The possible interaction of recombinant rho A proteins expressed in E. coli with photoexcited rhodopsin was studied by reconstitution with bovine rod outer segment (ROS) membranes depleted of endogenous GTP‐binding
Thomas Wieland, Alan Hall, Karl H. Jakobs, Peter Gierschik, Klaus Aktories, Isabel Ulibarri   +5 more
openaire   +3 more sources