Results 21 to 30 of about 82,160 (288)
TRP Channels Regulation of Rho GTPases in Brain Context and Diseases
Frontiers in Cell and Developmental Biology, 2020 Neurological and neuropsychiatric disorders are mediated by several pathophysiological mechanisms, including developmental and degenerative abnormalities caused primarily by disturbances in cell migration, structural plasticity of the synapse, and blood ...
Boris Lavanderos +12 more
doaj +1 more source
Identification of potential small molecule binding pockets on Rho family GTPases. [PDF]
PLoS ONE, 2012 Rho GTPases are conformational switches that control a wide variety of signaling pathways critical for eukaryotic cell development and proliferation. They represent attractive targets for drug design as their aberrant function and deregulated activity is
Juan Manuel Ortiz-Sanchez +5 more
doaj +1 more source
Gαq signalling from endosomes: A new conundrum
British Journal of Pharmacology, EarlyView., 2023 Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley +1 more source
Frontiers in Chemistry, 2021 Rac1 is a small signaling protein, which belongs to the Rho subfamily of Ras superfamily. It is activated by binding GTP and inactivated by exchanging GDP for GTP.
Chunwen Zheng +10 more
doaj +1 more source
Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex. [PDF]
PLoS ONE, 2014 The expression of the wild-type tumor-suppressor gene DBC2 (Deleted-in-Breast Cancer 2, a.k.a RhoBTB2) is suppressed in many cancers, in addition to breast cancer.
Jacob R Manjarrez +3 more
doaj +1 more source
p21-activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils [PDF]
, 2013 Neutrophils serve as a first line of defense in innate immunity owing in part to their ability to rapidly migrate towards chemotactic factors derived from invading pathogens.
Aslan, J.E. +9 more
core +15 more sources
Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins. [PDF]
PLoS ONE, 2017 The Rnd family of proteins, Rnd1, Rnd2 and Rnd3, are atypical Rho family GTPases, which bind to but do not hydrolyse GTP. They interact with plexins, which are receptors for semaphorins, and are hypothesised to regulate plexin signalling.
Thomas Wylie +3 more
doaj +1 more source
European Journal of Neurology, Volume 30, Issue 2, Page 511-526, February 2023., 2023 Abstract Background and purpose Charcot–Marie–Tooth disease (CMT) is a heterogeneous group of disorders caused by mutations in at least 100 genes. However, approximately 60% of cases with axonal neuropathies (CMT2) still remain without a genetic diagnosis. We aimed at identifying novel disease genes responsible for CMT2.
Silvia Cipriani +23 more
wiley +1 more source
Novel split-luciferase-based genetically encoded biosensors for noninvasive visualization of Rho GTPases. [PDF]
PLoS ONE, 2013 Rho family GTPases are critical regulators of many important cellular processes and the dysregulation of their activities is implicated in a variety of human diseases including oncogenesis and propagation of malignancy.
Weibing Leng +10 more
doaj +1 more source
RHGF-2 is an essential Rho-1 specific RhoGEF that binds to the multi-PDZ domain scaffold protein MPZ-1 in Caenorhabditis elegans. [PDF]
PLoS ONE, 2012 RhoGEF proteins activate the Rho family of small GTPases and thus play a key role in regulating fundamental cellular processes such as cell morphology and polarity, cell cycle progression and gene transcription.
Li Lin +5 more
doaj +1 more source