Results 21 to 30 of about 57,806 (244)

LncRNA THUMPD3-AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR-485-5p and ARHGAP8. [PDF]

Adv Sci (Weinh)
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Gong X, Chen L, Guo X, Jiang A, He Y, Yan C, Ma L, Gao J, Zhang J, Zhang B.   +9 more
europepmc   +2 more sources

Rho GTPases as Key Molecular Players within Intestinal Mucosa and GI Diseases

Cells, 2021
Rho proteins operate as key regulators of the cytoskeleton, cell morphology and trafficking. Acting as molecular switches, the function of Rho GTPases is determined by guanosine triphosphate (GTP)/guanosine diphosphate (GDP) exchange and their lipidation
Rashmita Pradhan, Phuong A. Ngo, Luz d. C. Martínez-Sánchez, Markus F. Neurath, Rocío López-Posadas   +4 more
doaj   +1 more source

Thrombopoietin and collagen in low doses cooperatively induce human platelet activation

Acute Medicine & Surgery, 2022
Aim In acute medicine, we occasionally treat life‐threatening conditions such as sepsis and trauma, which cause severe thrombocytopenia. Serum thrombopoietin levels have been reported to increase under the condition of thrombocytopenia related to ...
Tomoaki Doi, Takamitsu Hori, Takashi Onuma, Daisuke Mizutani, Kyohei Ueda, Yukiko Enomoto, Rie Matsushima‐Nishiwaki, Kumiko Tanabe, Tomoyuki Hioki, Haruhiko Tokuda, Toru Iwama, Hiroki Iida, Osamu Kozawa, Shinji Ogura   +13 more
doaj   +1 more source

Visualizing the subcellular localization of RHOB-GTP and GTPase-Effector complexes using a split-GFP/nanobody labelling assay

European Journal of Cell Biology, 2023
Small GTPases are highly regulated proteins that control essential signaling pathways through the activity of their effector proteins. Among the RHOA subfamily, RHOB regulates peculiar functions that could be associated with the control of the endocytic ...
Sebastian Castillo, Rémi Gence, Delphine Pagan, Faten Koraïchi, Catherine Bouchenot, Benoit J. Pons, Betty Boëlle, Aurélien Olichon, Isabelle Lajoie-Mazenc, Gilles Favre, Jean-Denis Pédelacq, Stéphanie Cabantous   +11 more
doaj   +1 more source

TRP Channels Regulation of Rho GTPases in Brain Context and Diseases

Frontiers in Cell and Developmental Biology, 2020
Neurological and neuropsychiatric disorders are mediated by several pathophysiological mechanisms, including developmental and degenerative abnormalities caused primarily by disturbances in cell migration, structural plasticity of the synapse, and blood ...
Boris Lavanderos, Boris Lavanderos, Ian Silva, Ian Silva, Pablo Cruz, Pablo Cruz, Octavio Orellana-Serradell, Octavio Orellana-Serradell, María Paz Saldías, María Paz Saldías, Oscar Cerda, Oscar Cerda, Oscar Cerda   +12 more
doaj   +1 more source

Phosphorylation induces altered protonation states and allosterically regulates Rac1-RhoGDI complex. [PDF]

Protein Sci
Abstract Rho GTPases, critical for cellular functions like motility, are sequestered in an inactive GDP‐bound state by RhoGDI. While site‐specific RhoGDI phosphorylation is known to trigger selective GTPase release, the precise mechanisms remain elusive.
Sinha K, Kumawat A, Jang H, Nussinov R, Chakrabarty S.   +4 more
europepmc   +2 more sources

Identification of potential small molecule binding pockets on Rho family GTPases. [PDF]

PLoS ONE, 2012
Rho GTPases are conformational switches that control a wide variety of signaling pathways critical for eukaryotic cell development and proliferation. They represent attractive targets for drug design as their aberrant function and deregulated activity is
Juan Manuel Ortiz-Sanchez, Sara E Nichols, Jacqueline Sayyah, Joan Heller Brown, J Andrew McCammon, Barry J Grant   +5 more
doaj   +1 more source

Computational Prediction of Hot Spots and Binding Site of Inhibitor NSC23766 on Rac1 Binding With Tiam1

Frontiers in Chemistry, 2021
Rac1 is a small signaling protein, which belongs to the Rho subfamily of Ras superfamily. It is activated by binding GTP and inactivated by exchanging GDP for GTP.
Chunwen Zheng, Xiaodong Wu, Xiaodong Wu, Ruijie Zeng, Lirui Lin, Lirui Lin, Liyan Xu, Enmin Li, Enmin Li, Geng Dong, Geng Dong   +10 more
doaj   +1 more source

Fluoride Activation of the Rho Family GTP-binding Protein Cdc42Hs [PDF]

Journal of Biological Chemistry, 1998
Aluminum tetrafluoride (AlF4-) activation of heterotrimeric G-protein alpha-subunits is a well established aspect of the biochemistry of these proteins; however, until recently it has been thought that AlF4- does not mediate effects on the Ras superfamily of low molecular weight GTP-binding proteins.
G R, Hoffman, N, Nassar, R E, Oswald, R A, Cerione   +3 more
openaire   +2 more sources

Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex. [PDF]

PLoS ONE, 2014
The expression of the wild-type tumor-suppressor gene DBC2 (Deleted-in-Breast Cancer 2, a.k.a RhoBTB2) is suppressed in many cancers, in addition to breast cancer.
Jacob R Manjarrez, Liang Sun, Thomas Prince, Robert L Matts   +3 more
doaj   +1 more source