Results 41 to 50 of about 82,160 (288)
Bio-Protocol, 2019 In our recently published paper, we highlight that during normal aging of C. elegans age-dependent aggregates of proteins form and lead to functional decline of tissues. The protocol described here details the isolation of two proteins from C. elegans in
Amberley Stephens +2 more
doaj +1 more source
The ciliary machinery is repurposed for T cell immune synapse trafficking of LCK [PDF]
, 2018 Upon engagement of the T cell receptor with an antigen-presenting cell, LCK initiates TCR signaling by phosphorylating its activation motifs. However, the mechanism of LCK activation specifically at the immune synapse is a major question.
Castro Sanchez, Patricia +6 more
core +1 more source
Rho GTPases and regulation of cell migration and polarization in human corneal epithelial cells. [PDF]
PLoS ONE, 2013 PURPOSE:Epithelial cell migration is required for regeneration of tissues and can be defective in a number of ocular surface diseases. This study aimed to determine the expression pattern of Rho family small G-proteins in human corneal epithelial cells ...
Aihua Hou +5 more
doaj +1 more source
A Process Model of Rho GTP-binding Proteins in the Context of Phagocytosis
Electronic Notes in Theoretical Computer Science, 2008 AbstractAt the early stages of the phagocytic signalling, Rho GTP-binding proteins play a key role. With the stimulus from the cell membrane and with the help from the regulators (GEF, GAP, Effector, GDI), these proteins serve as switches that interact with their environment in a complex manner.
Kahramanogullari, Ozan +2 more
openaire +2 more sources
Spatiotemporal model of cellular mechanotransduction via Rho and YAP [PDF]
, 2020 How cells sense and respond to mechanical stimuli remains an open question. Recent advances have identified the translocation of Yes-associated protein (YAP) between nucleus and cytoplasm as a central mechanism for sensing mechanical forces and regulating mechanotransduction.
arxiv +1 more source
Association of the Rho family small GTP-binding proteins with Rho GDP dissociation inhibitor (Rho GDI) in Saccharomyces cerevisiae [PDF]
Oncogene, 1997 The small GTP-binding proteins of the Rho family, consisting of the Rho, Rac, and Cdc42 subfamilies, are implicated in various cell functions, such as cell shape change, cell motility and cytokinesis, through reorganization of actin cytoskeleton. Rho GDI is a general regulator which forms a complex with the GDP-bound inactive form of the Rho family ...
Kazuma Tanaka +6 more
openaire +3 more sources
Identification of rho as a substrate for botulinum toxin C3-catalyzed ADP-ribosylation [PDF]
, 1989 Recombinant Aplysia rho and a GTP-binding protein purified from human neutrophil membranes (G22K) were ADP-ribosylated by botulinum toxin C3 with stoichiometries of 0.8 and 0.6, respectively.
Bokoch, Gary M. +2 more
core +1 more source
PAKing up to the endothelium [PDF]
, 2009 Angiogenesis recapitulates the growth of blood vessels that progressively expand and remodel into a highly organized and stereotyped vascular network. During adulthood, endothelial cells that formed the vascular wall retain their plasticity and can be ...
Armelle Le Guelte +3 more
core +6 more sources
Comparative Proteomic Analysis of Anti-Cancer Mechanism by Periplocin Treatment in Lung Cancer Cells
Cellular Physiology and Biochemistry, 2014 Background: Periplocin is used for treatment of rheumatoid arthritis, reinforcement of bones and tendons, palpitations or shortness of breath and lower extremity edema in traditional medicine. Our previous findings suggested that periplocin could inhibit
Zejun Lu +6 more
doaj +1 more source
Energy Transport and its Function in Heptahelical Transmembrane Proteins [PDF]
arXiv, 2022 Photoproteins such as bacteriorhodopsin (bR) and rhodopsin (Rho) need to effectively dissipate photoinduced excess energy to prevent their damage. Another well-studied G protein-coupled receptor (GPCR) containing 7 transmembrane (TM) helices is the B2 adrenergic receptor (B2AR), for which energy dissipation paths have been linked with allosteric ...
arxiv