In-silico, in-vitro, and proteomics analyses on repurposed drugs in targeting the small GTPase, Rho subfamily protein (Rho GTPase), and putative Rho GTPase-activating protein (RhoGAP) of Giardia lamblia. [PDF]
Jasni N +6 more
europepmc +1 more source
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing. [PDF]
Demirdizen E +12 more
europepmc +1 more source
ABSTRACT Platelet shortages and limited storage stability restrict global platelet transfusion capacity, highlighting the need for efficient in vitro platelet production systems. This study establishes a simple, non‐genetic and cost‐effective system for efficient in vitro platelet‐like particle (PLP) production from human hematopoietic stem/progenitor ...
Nittaya Jiamvoraphong +8 more
wiley +1 more source
Quantitative proteomics and phosphoproteomics reveal glucocorticoid stimulation of TLR and Rho GTPase signaling in neutrophil-like cells. [PDF]
Cho H, Nielsen ML, Olsen JV.
europepmc +1 more source
Polyphosphate uses mTOR, pyrophosphate, and Rho GTPase components to potentiate bacterial survival in <i>Dictyostelium</i>. [PDF]
Rahman RJ +5 more
europepmc +1 more source
Interaction Between Actin and Microtubules During Plant Development
ABSTRACT The dynamic interaction between actin filaments (AFs) and microtubules (MTs) plays a crucial role in regulating key developmental and physiological processes in plant cells, particularly in the formation of specialized cell types with distinct shapes and functions, such as pollen tubes, trichomes, and leaf epidermal cells.
Zining Wu +3 more
wiley +1 more source
The Rho GTPase signaling pathway modulates <i>Moraxella catarrhalis</i> invasion into human respiratory epithelial cells by regulating actin polymerization. [PDF]
Ma R +5 more
europepmc +1 more source
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves +3 more
wiley +1 more source
Helicobacter pylori Eradication Can Reverse Rho GTPase Expression in Gastric Carcinogenesis. [PDF]
Kim JL +4 more
europepmc +1 more source
Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie +5 more
wiley +1 more source

