Results 121 to 130 of about 49,205 (203)

Tumour‐Derived Extracellular Vesicles Reprogramme Tumour‐Associated Macrophages Into Immunosuppressive Phenotype via NOD1 Signalling in Clear Cell Renal Cell Carcinoma

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Clear cell renal cell carcinoma (ccRCC)‐derived extracellular vesicles (EVs) play a pivotal role in myeloid cell differentiation toward immunosuppressive phenotypes, yet the underlying mechanisms remain poorly understood. Through integrated single‐nucleus RNA sequencing, EV proteomics, and phenotype validation, we identified NOD1, a pattern ...
Xiu‐wu Pan, Mu‐chen Li, Tian‐yue Yang, Yi‐fan Liu, Jia‐lin Zhou, Yi‐fan Tang, Hong‐feng Zheng, Jian‐gui Liu, Zi‐chang Liu, Wen‐jie Ma, Wen‐yan Li, Zi‐xuan Gong, Shun Zhang, Hang‐biao Zhang, Bing‐nan Lu, Yun‐tao Yao, Dong‐hao Lyu, Guan‐yu Zhu, Yuan‐bo Zong, Han‐lin Yao, Ai‐ping Zhang, Jin Zeng, Si‐tu Xiong, Ke‐qin Dong, Wang Zhou, Bin Fu, Xin‐gang Cui   +26 more
wiley   +1 more source

The Rho GTPase regulator ARHGEF3 orchestrates hair placode budding by coordinating cell fate and P-cadherin patterning in mice. [PDF]

PLoS Biol
Kalyanakrishnan K, Beaudin A, Jetté A, Ghezelbash S, Ioana Hotea D, Chen J, Lefrançois P, Laurin M.   +7 more
europepmc   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

YAP controls cell migration and invasion through a Rho GTPase switch. [PDF]

Sci Signal
Shah SR, Ren C, Tippens ND, Park J, Mohyeldin A, Wang S, Vela G, Martinez-Gutierrez JC, Margolis SS, Schmidt S, Quiñones-Hinojosa A, Levchenko A.   +11 more
europepmc   +1 more source

Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu, Kaifeng Niu, Qingran Kong, Shaorong Gao   +3 more
wiley   +1 more source

ARHGAP11A, a member of Rho GTPase activating protein family, as a prognostic biomarker linked to DNA damage response across pan-cancer. [PDF]

BMC Cancer
Tan K, Wu Y, Zhang J, Ding Y, Cheng C, Yan Z, Wang X, Zhang L.   +7 more
europepmc   +1 more source

SnapShot: Rho Family GTPases

Cell, 2007
Vega, F M, Ridley, A J
openaire   +3 more sources

Distinct Effects of Nonselective Rho‐Kinase Inhibitor Fasudil and Selective Rho‐Kinase 2 Inhibitor KD025 on Serotonin and Dopamine Release in the Nucleus Accumbens of Mice

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
Fasudil perfusion in the NAc increased basal extracellular serotonin but not dopamine, and suppressed depolarization‐evoked release of both. In contrast, KD025 showed minimal effects on basal levels and selectively suppressed evoked serotonin release. ABSTRACT Recent studies have indicated that the Rho GTPase family and Rho‐kinases are associated with ...
Rinako Tanaka, Wenjun Zhu, Taku Nagai, Toshitaka Nabeshima, Kozo Kaibuchi, Norio Ozaki, Hiroaki Ikesue, Hiroyuki Mizoguchi, Kiyofumi Yamada   +8 more
wiley   +1 more source

The biochemical mechanism of Rho GTPase membrane binding, activation and retention in activity patterning. [PDF]

EMBO J
Armstrong MC, Weiß YR, Hoachlander-Hobby LE, Roy AA, Visco I, Moe A, Golding AE, Hansen SD, Bement WM, Bieling P.   +9 more
europepmc   +1 more source

MICOS and MIMAS, multifunctional assemblies linking mitochondrial biogenesis, architecture, and function

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Mitochondrial cristae architecture is central for optimal oxidative phosphorylation and a healthy mitochondrial physiology. The intricate architecture of the inner mitochondrial membrane relies on protein complexes that compartmentalize the membrane by imposing membrane curvature, forming membrane contact sites or membrane subdomains ...
Patrick Horten, Kuo Song, Nikolaus Pfanner, Heike Rampelt   +3 more
wiley   +1 more source