Results 131 to 140 of about 49,205 (203)

Computational model predicts function of Rho-GTPase binding for plexin receptor GAP activity on Rap1b via dynamic allosteric changes. [PDF]

Protein Sci
Bhattarai N, Morrison L, Gomes AF, Savage P, Sahoo AR, Buck M.   +5 more
europepmc   +1 more source

The Use of Statins in Parkinson's and Alzheimer's Disease: A 2021–2025 State‐of‐the‐Art Review of Clinical and Preclinical Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Luigi Maria Chiatto, Lucia Buccarello, Giuseppe Carota, Rocco Salvatore Calabrò, Carmela Rifici, Emanuela Esposito, Alessio Ardizzone, Giuseppe Caruso   +7 more
wiley   +1 more source

Retraction Note: Downregulation of the Rho GTPase pathway abrogates resistance to ionizing radiation in wild-type p53 glioblastoma by suppressing DNA repair mechanisms. [PDF]

Cell Death Dis
Magalhaes YT, Boell VK, Cardella GD, Forti FL.   +3 more
europepmc   +1 more source

Genome‐wide association studies reveal environment‐dependent genetic associations for plant architecture in regional soybean germplasm

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Regional soybean (Glycine max (L.) Merr.) breeding has produced germplasm adapted to different growing seasons, but the transferability of genetic associations associated with plant architecture across populations remains unclear. We performed genome‐wide association studies (GWASs) for plant height and main stem node number in 520 soybean ...
Pengshuo Shen, Qing Yang, Zheng Shi, Zhi Liu, Yan Feng, Sobhi F. Lamlom, Honglei Ren, Fulong Liu, Jiahao Ma, Yuechen Zhang, Long Yan   +10 more
wiley   +1 more source

Bacteria-Mediated Anomalous Rho GTPase Activation Alters Sperm Structure and Provokes Premature Capacitation Events: A Possible Mechanism of Infertility. [PDF]

Int J Mol Sci
Rivera B, Aroca C, González B, Guzmán N, Letelier P, Uribe P, Fornés M, Villegas JV, Boguen R.   +8 more
europepmc   +1 more source

Space biomedicine‐oriented bioink and biomimetic blood‒brain barrier

VIEW, Volume 7, Issue 3, June 2026.
Bioinks and bioprinting play a pivotal role in the successful delivery of cell models and the fabrication of tissue models for space biomedicine research. This study investigated the effects of hypergravity and vibration on two‐dimensional adherent cells and three‐dimensional embedded cells and provided methods for storing hybrid bioink and high ...
Ranran Yan, Ge Gao, YuJuan Li, YuLin Deng   +3 more
wiley   +1 more source

Zebrafish myo7aa affects congenital hearing by regulating Rho-GTPase signaling. [PDF]

Front Mol Neurosci
Xie B, Liang J, Jiang J, Zeng T, Liu L, Xie D, Zhu G, Xiong L, Zhang K, Liu D, Gong J, Chen X, Lai R, Xie H.   +13 more
europepmc   +1 more source

Aging Impairs Macrophage Phagocytosis Through Mitochondrial ROS‐Induced Collagen Production

Aging Cell, Volume 25, Issue 6, June 2026.
Aging compromises macrophage phagocytosis via the mitochondrial ROS‐driven overproduction of intracellular collagen. This excess collagen physically binds F‐actin, paralyzing cytoskeletal turnover; however, mtROS scavenging successfully rescues actin dynamics and restores phagocytic capacity.
Yuming Wang, Xin Xu, Nuanqin Shen, Ping Han, Liuyi Wu, Yi Jin, Yiming Sun, Lanlan Xiao, Jinyou Li, Lan Wang, Yunmei Yang, Qin Zhang, Weiqian Chen, Chaohui Yu, Bowen Wu   +14 more
wiley   +1 more source

Understanding the Role of Rho GTPase Activating Protein and Bone Marrow Kinase X: A Novel Target in Gastric Cancer Treatment. [PDF]

Asian Pac J Cancer Prev
Shaibu Z, Chen Z, Yang F, Xu X, Ji Y, Zhu W.   +5 more
europepmc   +1 more source

Mitochondrial Transplantation as a New Therapeutic Approach Against Cardiac and Renal Consequences in Male Rats With Myocardial Infarction

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim Myocardial infarction (MI) is one of the leading causes of death worldwide. MI is associated with cardiac structural and functional alterations. Among these, cardiac fibrosis may be significantly influenced by mitochondrial dysfunction. We sought to evaluate whether the injection of functional mitochondria from healthy muscle could improve
María Cuesta‐Corral, Alejandro Montoro‐Garrido, Ana Romero‐Miranda, Fabián Islas, Bunty Ramchandani, Ricardo Gredilla, Joaquín Fernández‐Irigoyen, Enrique Santamaría, Beatriz Delgado‐Valero, Sara Jiménez‐González, Raquel Rodrigues Díez, María Luisa Nieto, Victoria Cachofeiro, Ernesto Martínez‐Martínez   +13 more
wiley   +1 more source