Results 201 to 210 of about 72,889 (250)

Astrocyte Senescence Impairs Synaptogenesis due to Thrombospondin‐1 Loss

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Senescent hippocampal astrocytes lose TSP secretion, impairing excitatory synaptogenesis via the α2δ‐1 pathway. Restoring TSP‐1 rescues synaptic formation, revealing the contribution of astrocyte senescence to age‐related hippocampal synaptic decline.
Stefano Ercoli   +3 more
wiley   +1 more source

Rho GTPases Signaling in Zebrafish Development and Disease. [PDF]

open access: yesCells, 2020
Boueid MJ   +4 more
europepmc   +1 more source

MMP-9 Signaling Pathways That Engage Rho GTPases in Brain Plasticity. [PDF]

open access: yesCells, 2021
Figiel I   +6 more
europepmc   +1 more source

Skin Lipid–Microbe Interplay Links Staphylococcus hominis to Barrier Control in Adult Atopic Dermatitis

open access: yesAllergy, Volume 81, Issue 2, Page 454-467, February 2026.
This study investigates mutual interaction of skin microbes and surface lipids in AD using the advanced method of shotgun lipidomics with ultra‐broad coverage of lipids and 16S amplicon sequencing of tape strips taken from lesional and non‐lesional AD and healthy controls.
Madhumita Bhattacharyya   +14 more
wiley   +1 more source

STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development. [PDF]

open access: yesJ Neurosci, 2021
Matsuki T   +5 more
europepmc   +1 more source

Proteomic profiling of porcine seminal extracellular vesicles reveals potential in vivo fertility biomarkers

open access: yesAndrology, Volume 14, Issue 2, Page 555-570, February 2026.
Abstract Background Predicting male fertility in farm animals remains a challenge. Seminal plasma (SP) contains a high amount of heterogeneous seminal extracellular vesicles (sEVs), believed involved in reproductive processes and maybe key to understanding male fertility.
Isabel Barranco   +6 more
wiley   +1 more source

Heart matters: How glucose‐ and lipid‐modulating drugs remodel epicardial adipose tissue accumulation, inflammatory patterns and browning

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 878-894, February 2026.
Abstract Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot located between the myocardium and the visceral pericardium, exerting direct paracrine and vasocrine effects on the heart and coronary vessels. Under physiological conditions, EAT supports myocardial energy metabolism and thermoregulation through fatty acid supply and
Elisabeth Heuboeck   +2 more
wiley   +1 more source

Dysregulation of Rho GTPases in Human Cancers. [PDF]

open access: yesCancers (Basel), 2020
Jung H, Yoon SR, Lim J, Cho HJ, Lee HG.
europepmc   +1 more source

Structural and functional dissection of the WH2/DAD motif of INF2, a formin linked to human inherited degenerative disorders

open access: yesThe FEBS Journal, Volume 293, Issue 3, Page 825-841, February 2026.
The INF2 WH2/DAD domain, composed of hydrophobic and basic regions, forms a single α‐helix in solution. The hydrophobic segment is essential for INF2 function, as its deletion disrupts actin dynamics and causes nuclear abnormalities, like those seen in pathogenic INF2 DID variants. In contrast, natural INF2 WH2/DAD variants found in patients with renal
Leticia Labat‐de‐Hoz   +5 more
wiley   +1 more source

Hormones Secretion and Rho GTPases in Neuroendocrine Tumors. [PDF]

open access: yesCancers (Basel), 2020
Streit L   +4 more
europepmc   +1 more source

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