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The FASEB Journal, Volume 40, Issue 1, 15 January 2026.BWCFF, a severe disease with neurological symptoms, is caused by mutations in the cytoskeletal actin genes. Patient‐derived fibroblasts carrying the R196H β‐actin mutation were compared to wild type cells. The mutant cells displayed slower proliferation and migration and a lower F‐actin content, which correlated with reduced cell stiffness ...
Éva Gráczer +12 more
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Uncovering the secret life of Rho GTPases. [PDF]
Elife, 2019 Perry JA, Maddox AS.
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Rho GTPases and the emerging role of tunneling nanotubes in physiology and disease.
Am J Physiol Cell Physiol, 2020 Zhang S, Kazanietz MG, Cooke M.
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Biochemical Society Transactions, 2012
Rho GTPases comprise a family of molecular switches that control signal transduction pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes an interaction with target (effector) proteins to generate a cellular response. A highly conserved function of Rho GTPases from yeast to humans is to control the actin cytoskeleton,
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Rho GTPases comprise a family of molecular switches that control signal transduction pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes an interaction with target (effector) proteins to generate a cellular response. A highly conserved function of Rho GTPases from yeast to humans is to control the actin cytoskeleton,
openaire +2 more sources
2016
The Ras-homology (Rho) GTPases were initially linked to regulation of actin cytoskeletal architecture, maintenance of cell shape and polarity, and to cell migration. Subsequent studies have shown that Rho GTPases are involved in highly diverse cellular and biological functions, many of which contribute to tumorigenesis.
Lukey, M. J., Cerione, R. A.
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The Ras-homology (Rho) GTPases were initially linked to regulation of actin cytoskeletal architecture, maintenance of cell shape and polarity, and to cell migration. Subsequent studies have shown that Rho GTPases are involved in highly diverse cellular and biological functions, many of which contribute to tumorigenesis.
Lukey, M. J., Cerione, R. A.
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Experimental Cell Research, 1999
Rho GTPases regulate many important processes in all eukaryotic cells, including the organization of the actin cytoskeleton, gene transcription, cell cycle progression, and membrane trafficking. Their activity is regulated by signals originating from different classes of surface receptors including G-protein-coupled receptors, tyrosine kinase receptors,
L, Kjoller, A, Hall
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Rho GTPases regulate many important processes in all eukaryotic cells, including the organization of the actin cytoskeleton, gene transcription, cell cycle progression, and membrane trafficking. Their activity is regulated by signals originating from different classes of surface receptors including G-protein-coupled receptors, tyrosine kinase receptors,
L, Kjoller, A, Hall
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BioFactors, 2013
AbstractRho GTPases are a family of small GTPases, which play an important role in the regulation of the actin cytoskeleton. Not surprisingly, Rho GTPases are crucial for cell migration and therefore highly important for cancer cell invasion and the formation of metastases. In addition, Rho GTPases are involved in growth and survival of tumor cells, in
Li, Hui +3 more
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AbstractRho GTPases are a family of small GTPases, which play an important role in the regulation of the actin cytoskeleton. Not surprisingly, Rho GTPases are crucial for cell migration and therefore highly important for cancer cell invasion and the formation of metastases. In addition, Rho GTPases are involved in growth and survival of tumor cells, in
Li, Hui +3 more
openaire +3 more sources