Results 211 to 220 of about 191,346 (272)

Ba2+‐Induced Vasoconstriction as a Model to Investigate the Dynamin Dependence of Biological Processes Regulating Vascular Tone

Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.
ABSTRACT Understanding the mechanisms underpinning vascular smooth muscle contraction, which are critical targets for cardiovascular disease treatment, is essential for developing novel therapeutic agents. Recently, the role of mitochondrial fission as a key modulatory event in the vascular contractile process has been questioned.
Mariangela Gentile, Alice Panti, Eugenio Paccagnini, Pietro Lupetti, Sergio Bova, Fabio Fusi   +5 more
wiley   +1 more source

The Function of Two Rho Family GTPases Is Determined by Distinct Patterns of Cell Surface Localization

, 2010
Hao Wu, Patrick Brennwald
openalex   +2 more sources

P2‐446: R‐flurbiprofen regulates motility and inflammatory gene expression in astrocytes via Rho‐GTPase/ERK dependent signaling [PDF]

, 2008
Mathieu Lichtenstein, Mariela Susana Borán, Paulina Carriba, Beata Wójciak‐Stothard, Agustina Garcı́a, Elena Galea   +5 more
openalex   +1 more source

Vasoactivity of Rac GTPase, Cytohesin and Kinase Inhibitors in Renal Interlobar and Coronary Arteries Reveals Shared and Distinct Patterns of Inhibitory Effects in Vascular and Prostate Smooth Muscle Contraction

Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.
ABSTRACT Inhibition of vasocontraction accounts for side effects in treating voiding symptoms in benign prostatic hyperplasia (BPH). We examined the vasoactivity of compounds previously showing inhibition of prostate smooth muscle contraction. Contractions of porcine renal interlobar and coronary arteries were induced by agonists or electric field ...
Guangyang Liu, Sheng Hu, Alexander Tamalunas, Oluwafemi Kale, Yajie Xu, Christian G. Stief, Martin Hennenberg   +6 more
wiley   +1 more source

Cross-talk between Rho GTPases and PI3K in the neutrophil

Small GTPases, 2019
B. McCormick, Julia Y. Chu, S. Vermeren
semanticscholar   +1 more source

Mechanisms That Prevent Vascular Leakage During Leukocyte Extravasation

Acta Physiologica, Volume 241, Issue 12, December 2025.
ABSTRACT Background Inflammation is the response of the immune system against harmful stimuli in tissues. Leukocyte extravasation or TransEndothelial Migration (TEM) is a crucial step during inflammation, in which leukocytes migrate over the endothelial barrier toward the damaged tissue.
Siem J. de Haan, Jaap D. van Buul
wiley   +1 more source

Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases

Benjamin R. Duewell, Naomi E. Wilson, Gabriela M Bailey, Sarah E. Peabody, Scott D. Hansen   +4 more
openalex   +1 more source

Essential developmental processes in Physcomitrium patens require distinct levels of total activity provided by functionally redundant PpROP GTPases

New Phytologist, Volume 248, Issue 6, Page 2865-2890, December 2025.
Summary RHO (RAS homologous) GTPases regulate important cellular and developmental processes in most eukaryotes. Plant‐specific ROP (RHO of plants) GTPase families expanded and functionally diversified during the evolution of vascular plants, but contain few members in nonvascular extant relatives of early land plants.
Aude Le Bail, Benedikt Kost, Janina Nüssel, Tamara Isabeau Lolis, David Koch, Hildegard Voll, Sylwia Schulmeister, Alexander Kaier, Karin Ljung, Maria Ntefidou   +9 more
wiley   +1 more source

Paving the Rho in cancer metastasis: Rho GTPases and beyond.

Pharmacology and Therapeutics, 2017
S. Jansen, R. Gosens, T. Wieland, Martina Schmidt   +3 more
semanticscholar   +1 more source