The early stages of heart development: insights from chicken embryos [PDF]
, 2016 The heart is the first functioning organ in the developing embryo and the detailed understanding of the molecular and cellular mechanisms involved in its formation provides insights into congenital malformations affecting its function and therefore the ...
Alsan +19 more
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PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex [PDF]
, 2017 PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signalling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein β ...
Anderson +82 more
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Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells [PDF]
, 2005 Udgivelsesdato: 2005-OctCdc42 is a small GTPase involved in the regulation of the cytoskeleton and cell polarity. To test whether Cdc42 has an essential role in the formation of filopodia or directed cell migration, we generated Cdc42-deficient ...
CZUCHRA, A +7 more
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Journal of Pharmacological Sciences, 2010 .: MicroRNAs (miRNAs) play important roles in normal and diseased cell functions. The small-GTPase RhoA is one of the key proteins of bronchial smooth muscle (BSM) contraction, and an upregulation of RhoA has been demonstrated in BSMs of experimental ...
Yoshihiko Chiba, Miwa Misawa
doaj +1 more source
A sulfated carbohydrate epitope inhibits axon regeneration after injury [PDF]
, 2012 Chondroitin sulfate proteoglycans (CSPGs) represent a major barrier to regenerating axons in the central nervous system (CNS), but the structural diversity of their polysaccharides has hampered efforts to dissect the structure-activity relationships ...
Brown, Joshua M. +14 more
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CellsRhoA is a major regulator of the actin cytoskeleton. Its function in the nucleus, however, is unclear. Fusing wildtype, fast cycling, constitutively active, and dominant negative forms of RhoA with tags promoting nuclear or cytoplasmic location and ...
Lap P. Nguyen +4 more
doaj +1 more source
Direct genetic demonstration of Gα13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement [PDF]
, 2000 G2A is an orphan G protein-coupled receptor (GPCR), expressed predominantly in T and B cells and homologous to a small group of GPCRs of unknown function expressed in lymphoid tissues.
Feramisco, Jamison D. +6 more
core
Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity. [PDF]
, 2016 Heart of Glass (HEG1), a transmembrane receptor, and Rasip1, an endothelial-specific Rap1-binding protein, are both essential for cardiovascular development.
de Kreuk, Bart-Jan +5 more
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RhoA/Rho‐kinases in asthma: from pathogenesis to therapeutic targets
Clinical & Translational Immunology, 2020 Asthma is a chronic and heterogeneous disease characterised by airway inflammation and intermittent airway narrowing. The key obstacle in the prevention and treatment of asthma has been our incomplete understanding of its aetiology and biological ...
Yan Zhang +7 more
doaj +1 more source
RhoA is dispensable for axon guidance of sensory neurons in the mouse dorsal root ganglia
Frontiers in Molecular Neuroscience, 2012 RhoA, a member of Rho family small GTPases, has been shown to play important roles in axon guidance. However, it remains unknown whether RhoA is actually required for any axon guidance events in vivo in the mammalian nervous system.
Jennifer R Leslie +5 more
doaj +1 more source