Results 91 to 100 of about 123,069 (394)
Peptide Bbeta(15-42) preserves endothelial barrier function in shock [PDF]
, 2009 Loss of vascular barrier function causes leak of fluid and proteins into tissues, extensive leak leads to shock and death. Barriers are largely formed by endothelial cell-cell contacts built up by VE-cadherin and are under the control of RhoGTPases. Here
Atrasheuskaya, Alena +12 more
core
RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry [PDF]
, 2018 Ciliopathies are a group of genetically heterogeneous disorders, characterized by defects in cilia genesis or maintenance. Mutations in the RPGR gene and its interacting partners, RPGRIP1 and RPGRIP1L, cause ciliopathies, but the function of their ...
Aguirre +68 more
core +3 more sources
A RhoA–YAP–c-Myc signaling axis promotes the development of polycystic kidney disease
Genes & Development, 2018 Cai et al. identified the Hippo signaling effector YAP and its transcriptional target, c-Myc, as promoters of cystic kidney pathogenesis. A comprehensive kinase inhibitor screen identified a signaling pathway involving the RhoGEF LARG, the small GTPase ...
Jing Cai +6 more
semanticscholar +1 more source
Arthritis Care &Research, EarlyView.Objective This study aims to develop hip morphology‐based radiographic hip osteoarthritis (RHOA) risk prediction models and investigates the added predictive value of hip morphology measurements and the generalizability to different populations. Methods We combined data from nine prospective cohort studies participating in the Worldwide Collaboration ...
Myrthe A. van den Berg +26 more
wiley +1 more source
ANLN Directly Interacts with RhoA to Promote Doxorubicin Resistance in Breast Cancer Cells
Cancer Management and Research, 2020 Feng Wang,* Zhen Xiang,* Teng Huang,* Min Zhang, Wei-Bing Zhou Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei ...
Wang F +4 more
doaj
Molecular Medicine, 2023 Background The pathogenesis of benign prostatic hyperplasia (BPH) has not been fully elucidated. Ras homology family member A (RhoA) plays an important role in regulating cell cytoskeleton, growth and fibrosis.
Shidong Shan +16 more
doaj +1 more source
Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]
, 2006 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E +6 more
core +1 more source
RHOA in Gastric Cancer: Functional Roles and Therapeutic Potential
Frontiers in Genetics, 2019 The well-known signal mediator and small GTPase family member, RHOA, has now been associated with the progression of specific malignancies. In this review, we appraise the biomedical literature regarding the role of this enzyme in gastric cancer (GC ...
S. Nam, Jung Ho Kim, Dae Ho Lee
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.Many cancer nanotherapeutics, while potent, suffer from the inability to escape from the tumor vasculature, especially in the absence of endothelial permeability. In this work, ultrasmall gold nanoclusters could engineer nanomaterials induced endothelial leakiness (NanoEL) and harness strong NIR induced photothermal characteristics to suppress tumor ...
Nengyi Ni +8 more
wiley +1 more source
RhoA G17E/Vav1 Signaling Induces Cancer Invasion via Matrix Metalloproteinase-9 in Gastric Cancer
Technology in Cancer Research & Treatment, 2023 Background: RAS homolog family member A (RhoA), a member of the Rho family of small GTPases, and Vav1, a guanine nucleotide exchange factor for Rho family GTPases, have been reported to activate pathways related to the actin cytoskeleton and regulation ...
Satoshi Nakamura MD +12 more
doaj +1 more source