Results 21 to 30 of about 123,069 (394)
Cells, 2020 Vascular smooth muscle cells (VSMCs) are the predominant cell type in the blood vessel wall. Changes in VSMC actomyosin activity and morphology are prevalent in cardiovascular disease. The actin cytoskeleton actively defines cellular shape and the LInker
Lauren Porter +12 more
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Frontiers in Bioscience-Landmark, 2021 Background: Cystic fibrosis transmembrane conductance regulator (CFTR) has been associated with vascular tone and blood pressure (BP), however, its role in the genesis of hypertension remains elusive.
Liyan Zhao +8 more
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p66Shc mediates anoikis through RhoA [PDF]
The Journal of Cell Biology, 2007 Detachment of parenchymal cells from a solid matrix switches contextual cues from survival to death during anoikis. Marked shape changes accompany detachment and are thought to trigger cell death, although a working model to explain the coordination of attachment sensation, shape change, and cell fate is elusive.
Ma, Zhenyi +4 more
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Theranostics, 2020 Hypoxia is one of the important properties of solid tumor. However, oxygen supply within tumors is generally heterogeneous according to the distance from the nearest blood vessel.
Haiou Yang +13 more
semanticscholar +1 more source
srGAP2 deactivates RhoA to control the duration of thrombin-mediated endothelial permeability
Vascular Biology, 2022 The endothelial barrier is a tightly regulated gateway in the transport of material between circulation and the tissues. Inflammatory mediators such as thrombin are able to open paracellular spaces in the endothelial monolayer to allow the extravasation ...
Alba Lopez Rioja +2 more
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ROCK (RhoA/Rho Kinase) in Cardiovascular–Renal Pathophysiology: A Review of New Advancements
Journal of Clinical Medicine, 2020 Rho-associated, coiled-coil containing kinases (ROCK) were originally identified as effectors of the RhoA small GTPase and found to belong to the AGC family of serine/threonine kinases.
T. Seccia +3 more
semanticscholar +1 more source
Destruction of RhoA CULtivates Actin [PDF]
Molecular Cell, 2009 Cullin 3, the core subunit of the CRL3 ubiquitin ligase family, is essential for development, but its substrates remain poorly defined. Here, Chen et al. (2009) report that CRL3(BACURD) targets the RhoA GTPase for degradation, thereby maintaining actin cytoskeleton integrity.
Wu, Shuangding, Wolf, Dieter A.
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Spatiotemporal Regulation of RhoA during Cytokinesis [PDF]
Current Biology, 2018 The active form of the small GTPase RhoA is necessary and sufficient for formation of a cytokinetic furrow in animal cells. Despite the conceptual simplicity of the process, the molecular mechanisms that control it are intricate and involve redundancy at multiple levels. Here, we discuss our current knowledge of the mechanisms underlying spatiotemporal
Angika Basant, M. Glotzer
semanticscholar +3 more sources
Effect of miRNA-200b on the proliferation and apoptosis of cervical cancer cells by targeting RhoA
Open Medicine, 2020 This article aims to investigate the effect of miRNA-200b on the proliferation and apoptosis of cervical cancer cells by targeting RhoA.
He Lijie +5 more
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OncoImmunology, 2020 A missense mutation in RHOA encoding p.Gly17 Val has been reported to occur frequently in angioimmunoblastic T-cell lymphoma (AITL). Here, we describe a murine model which expresses the human RHOA mutant gene product in a T-cell specific manner and ...
Gyu Jin Lee +6 more
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