Results 31 to 40 of about 104,378 (298)
Trends in Peptide and Protein Sciences, 2017 Breast cancer is the most prevalent diagnosed cancer and the second cause of cancer death among women worldwide. There are different mechanisms that play crucial roles in the onset and progression of breast cancer including microRNAs. microRNAs are small
Samira Mohammadi Yeganeh +4 more
doaj +1 more source
DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration. [PDF]
, 2010 Deleted in liver cancer 1 (DLC1) is a RhoGTPase activation protein-containing tumor suppressor that associates with various types of cancer. Although DLC2 shares a similar domain structure with that of DLC1, the function of DLC2 is not well characterized.
Chen, N-T +5 more
core +3 more sources
RhoA of the Rho family small GTPases is essential for B lymphocyte development. [PDF]
PLoS ONE, 2012 RhoA is a member of the Rho family small GTPases that are implicated in various cell functions including proliferation and survival. However, the physiological role of RhoA in vivo remains largely unknown.
Shuangmin Zhang +3 more
doaj +1 more source
Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling [PDF]
, 2012 The functions of many organs depend on the generation of an epithelium. The transition from a set of loosely connected nonpolarized cells to organized sheets of closely associated polarized epithelial cells requires the assembly of specialized cell ...
Pieters, Tim +2 more
core +2 more sources
Vascular smooth muscle contraction in hypertension [PDF]
, 2018 Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia and chronic kidney disease.
Alves-Lopes, Rheure +6 more
core +1 more source
Activation of RHOA–VAV1 signaling in angioimmunoblastic T-cell lymphoma [PDF]
, 2017 Somatic G17V RHOA mutations were found in 50–70% of angioimmunoblastic T-cell lymphoma (AITL). The mutant RHOA lacks GTP binding capacity, suggesting defects in the classical RHOA signaling.
Enami T +23 more
core +2 more sources
Induced Remodelling of Astrocytes In Vitro and In Vivo by Manipulation of Astrocytic RhoA Activity
Cells, 2023 Structural changes of astrocytes and their perisynaptic processes occur in response to various physiological and pathophysiological stimuli. They are thought to profoundly affect synaptic signalling and neuron-astrocyte communication.
Cátia Domingos +8 more
doaj +1 more source
Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. [PDF]
, 2012 Protein turnover through cullin-3 is tightly regulated by posttranslational modifications, the COP9 signalosome, and BTB/POZ-domain proteins that link cullin-3 to specific substrates for ubiquitylation.
Chen, Ju +3 more
core +2 more sources
Pathogens, 2019 Bacterial meningitis is currently recognized as one of the most important life-threatening infections of the central nervous system (CNS) with high morbidity and mortality, despite the advancements in antimicrobial treatment.
Lu Liu +9 more
doaj +1 more source
Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling.
PLoS Biology, 2020 The small GTPase RhoA is a central signaling enzyme that is involved in various cellular processes such as cytoskeletal dynamics, transcription, and cell cycle progression.
Jason Z Zhang +5 more
doaj +1 more source