Results 31 to 40 of about 68,847 (285)

Effects of diet and antihyperglycemic drugs on erectile dysfunction: A systematic review

Andrology, Volume 11, Issue 2, Page 282-294, February 2023., 2023
Abstract Background Erectile dysfunction is recognized as one of the complications of diabetes mellitus. To date, a wide gap of knowledge is present on the efficacy of pharmacological treatments of diabetes mellitus on erectile function, acting not only through metabolic control. Similarly, the effects of different diet regimens on erectile dysfunction
Giuseppe Defeudis, Rossella Mazzilli, Alfonso Maria Di Tommaso, Virginia Zamponi, Francesco Carlomagno, Dario Tuccinardi, Mikiko Watanabe, Antongiulio Faggiano, Daniele Gianfrilli   +8 more
wiley   +1 more source

Leptin Induces MMP-1 Expression Through the RhoA/ERK1/2/NF-κB Axis in Human Intervertebral Disc Cartilage Endplate-Derived Stem Cells

Journal of Inflammation Research, 2023
Kuo-Feng Hua,1,2,* Lan-Hui Li,3,* Hsin-Chiao Yu,4 Wei-Ting Wong,1 Hsien-Ta Hsu4,5 1Department of Biotechnology and Animal Science, National Ilan University, Yilan, 26047, Taiwan; 2Department of Medical Research, China Medical University Hospital,
Hua KF, Li LH, Yu HC, Wong WT, Hsu HT
doaj  

Targeting Mechanics-Induced Fibroblast Activation through CD44-RhoA-YAP Pathway Ameliorates Crystalline Silica-Induced Silicosis

Theranostics, 2019
Silicosis is pneumoconiosis of the lung, usually resulting from prolonged exposure to crystalline silica (CS). The hallmark of silicosis is excessive extracellular matrix (ECM) deposition produced by activated fibroblasts.
Siyi Li, Chao Li, Yiting Zhang, Xiu He, Xi Chen, Xinning Zeng, Fangwei Liu, Ying Chen, Jie Chen   +8 more
semanticscholar   +1 more source

A Computational Model of YAP/TAZ Mechanosensing [PDF]

Biophysical Journal, 110(11), 2540-2550 (2016), 2016
In cell proliferation, stem cell differentiation, chemoresistance and tissue organization, the ubiquitous role of YAP/TAZ continues to impact our fundamental understanding in numerous physiological and disease systems. YAP/TAZ is an important signaling nexus integrating diverse mechanical and biochemical signals, such as ECM stiffness, adhesion ligand ...
arxiv   +1 more source

Investigating the Relation between miR-31 and RhoA Expressions in Breast Cancer Clinical Samples and Cell Lines: A Controversial Matter

Trends in Peptide and Protein Sciences, 2017
Breast cancer is the most prevalent diagnosed cancer and the second cause of cancer death among women worldwide. There are different mechanisms that play crucial roles in the onset and progression of breast cancer including microRNAs. microRNAs are small
Samira Mohammadi Yeganeh, Mohammadreza Malekian, Vahid Kia, Ameneh Koochaki, Mahdi Paryan   +4 more
doaj   +1 more source

Pyrin Inflammasome Activation and RhoA Signaling in the Autoinflammatory Diseases FMF and HIDS

Nature Immunology, 2016
Mutations in the genes encoding pyrin and mevalonate kinase (MVK) cause distinct interleukin-1β (IL-1β)-mediated autoinflammatory diseases: familial Mediterranean fever (FMF) and hyperimmunoglobulinemia D syndrome (HIDS). Pyrin forms an inflammasome when
Y. Park, G. Wood, D. Kastner, J. Chae
semanticscholar   +1 more source

Dynamic induction of the myelin‐associated growth inhibitor Nogo‐A in perilesional plasticity regions after human spinal cord injury

Brain Pathology, Volume 33, Issue 1, January 2023., 2023
Nogo‐A oligodendrocytes expression emerges at perilesional regions over time and suggests an extended therapeutical window for anti‐Nogo‐A pathway trageting interventrions beyond four weeks in patients after spinal cord injury. Abstract The myelin‐associated inhibitor Nogo‐A (Reticulon 4, RTN4) restricts axonal outgrowth, plasticity, and neural ...
Carmen Schwaiger, Thomas Haider, Verena Endmayr, Tobias Zrzavy, Victoria E. Gruber, Gerda Ricken, Anika Simonovska, Simon Hametner, Jan M. Schwab, Romana Höftberger   +9 more
wiley   +1 more source

RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling

Molecular Medicine, 2023
Background The cytoskeletal architecture of osteoclasts (OCs) and bone resorption activity must be appropriately controlled for proper bone remodeling, which is associated with osteoporosis.
Jirong Wang, Chengyun Xu, Jing Zhang, Yizhong Bao, Ying Tang, Xiaoling Lv, Bo Ma, Ximei Wu, Genxiang Mao   +8 more
doaj   +1 more source

Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The actin cytoskeleton is central to many cellular processes involving changes in cell shape, migration, and adhesiveness. Therefore, there is a great interest in the identification of the signaling pathways leading to the regulation of ...
Carlos Pardo-Pastor, F. Rubio-Moscardo, Marina Vogel-González, Selma A. Serra, A. Afthinos, Sanela Mrkonjić, O. Destaing, J. F. Abenza, J. Fernández-Fernández, X. Trepat, C. Albigès-Rizo, K. Konstantopoulos, M. Valverde   +12 more
semanticscholar   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source