Results 31 to 40 of about 123,069 (394)

Review – Nutraceuticals Can Target Asthmatic Bronchoconstriction: NADPH Oxidase-Dependent Oxidative Stress, RhoA and Calcium Dynamics

open access: yesJournal of Asthma and Allergy, 2021
Mark F McCarty,1 James J DiNicolantonio,2 Aaron Lerner3 1Catalytic Longevity Foundation, San Diego, CA, USA; 2Department of Preventive Cardiology, Saint Luke’s Mid America Heart Institute, Kansas, MO, USA; 3Chaim Sheba Medical Center, The ...
McCarty MF, DiNicolantonio JJ, Lerner A
doaj  

Leptin Induces MMP-1 Expression Through the RhoA/ERK1/2/NF-κB Axis in Human Intervertebral Disc Cartilage Endplate-Derived Stem Cells

open access: yesJournal of Inflammation Research, 2023
Kuo-Feng Hua,1,2,* Lan-Hui Li,3,* Hsin-Chiao Yu,4 Wei-Ting Wong,1 Hsien-Ta Hsu4,5 1Department of Biotechnology and Animal Science, National Ilan University, Yilan, 26047, Taiwan; 2Department of Medical Research, China Medical University Hospital,
Hua KF, Li LH, Yu HC, Wong WT, Hsu HT
doaj  

RhoA Proteolysis Regulates the Actin Cytoskeleton in Response to Oxidative Stress. [PDF]

open access: yesPLoS ONE, 2016
The small GTPase RhoA regulates the actin cytoskeleton to affect multiple cellular processes including endocytosis, migration and adhesion. RhoA activity is tightly regulated through several mechanisms including GDP/GTP cycling, phosphorylation ...
Marie-Pier Girouard   +4 more
doaj   +1 more source

Aging-associated changes in microRNA expression profile of internal anal sphincter smooth muscle: Role of microRNA-133a. [PDF]

open access: yes, 2016
A comprehensive genomic and proteomic, computational, and physiological approach was employed to examine the (previously unexplored) role of microRNAs (miRNAs) as regulators of internal anal sphincter (IAS) smooth muscle contractile phenotype and basal ...
Addya, Sankar   +6 more
core   +3 more sources

Phosphorylation and Activation of RhoA by ERK in Response to Epidermal Growth Factor Stimulation. [PDF]

open access: yesPLoS ONE, 2016
The small GTPase RhoA has been implicated in various cellular activities, including the formation of stress fibers, cell motility, and cytokinesis. In addition to the canonical GTPase cycle, recent findings have suggested that phosphorylation further ...
Junfeng Tong   +3 more
doaj   +1 more source

PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells [PDF]

open access: yes, 2007
Interactions between leukocytes and vascular endothelial cells are mediated by a complex set of membrane adhesion molecules which transduce bi-directional signals in both cell types.
Adamson   +53 more
core   +2 more sources

RhoA/Rho‐kinases in asthma: from pathogenesis to therapeutic targets

open access: yesClinical & Translational Immunology, 2020
Asthma is a chronic and heterogeneous disease characterised by airway inflammation and intermittent airway narrowing. The key obstacle in the prevention and treatment of asthma has been our incomplete understanding of its aetiology and biological ...
Yan Zhang   +7 more
semanticscholar   +1 more source

Rho GTPases and their downstream effectors in megakaryocyte biology

open access: yesPlatelets, 2019
Megakaryocytes differentiate from hematopoietic stem cells in the bone marrow. The transition of megakaryocytes to platelets is a complex process. Thereby, megakaryocytes extend proplatelets into sinusoidal blood vessels, where the proplatelets undergo ...
Irina Pleines   +2 more
doaj   +1 more source

RhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling. [PDF]

open access: yesPLoS ONE, 2017
OBJECTIVE:Epidermal stem cells (ESCs) play a critical role in wound healing, but the mechanism underlying ESC proliferation is not well defined. Here, we explore the effects of RhoA on ESC proliferation and the possible underlying mechanism.
Fan Wang   +12 more
doaj   +1 more source

The Small GTPase RHOA Links SLP65 Activation to PTEN Function in Pre B Cells and Is Essential for the Generation and Survival of Normal and Malignant B Cells

open access: yesFrontiers in Immunology, 2022
The generation, differentiation, survival and activation of B cells are coordinated by signals emerging from the B cell antigen receptor (BCR) or its precursor, the pre-BCR.
Anila Vadakumchery   +22 more
doaj   +1 more source

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