Results 41 to 50 of about 68,847 (285)

Inhibition of the RhoA/Rho-associated, coiled-coil-containing protein kinase-1 pathway is involved in the therapeutic effects of simvastatin on pulmonary arterial hypertension

Clinical and Experimental Hypertension, 2018
Background: Recent research has shown that statins improve pulmonary arterial hypertension (PAH), but their mechanisms of action are not fully understood.
Wei-Hua Liu, Xiao-Hong Xu, Qin Luo, Hong-Liang Zhang, Yong Wang, Qun-Ying Xi, Zhi-Hui Zhao, Zhi-Hong Liu   +7 more
doaj   +1 more source

CXCL12/CXCR4 promotes inflammation-driven colorectal cancer progression through activation of RhoA signaling by sponging miR-133a-3p

Journal of experimental & clinical cancer research : CR, 2019
BackgroundActivation of CXCL12/CXCR4 axis has been found to be associated with invasion and metastasis in many cancers. However, the underlying mechanism remains elusive.
Xinfeng Yu, Dong Wang, Xiaohui Wang, Shi-Yue Sun, Yu-Hang Zhang, Shuqing Wang, Rong-Rong Miao, Xiaoxue Xu, Xian-Jun Qu   +8 more
semanticscholar   +1 more source

Gαq signalling from endosomes: A new conundrum

British Journal of Pharmacology, EarlyView., 2023
Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley   +1 more source

Arp2/3-Branched Actin Maintains an Active Pool of GTP-RhoA and Controls RhoA Abundance

Cells, 2019
Small GTPases regulate cytoskeletal dynamics, cell motility, and division under precise spatiotemporal control. Different small GTPases exhibit cross talks to exert feedback response or to act in concert during signal transduction.
Yuxing Huang, Xin Yi, Chenlu Kang, Congying Wu   +3 more
doaj   +1 more source

Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling

Molecular Psychiatry, 2018
Atypical brain connectivity is a major contributor to the pathophysiology of neurodevelopmental disorders (NDDs) including autism spectrum disorders (ASDs).
Melanie Richter, N. Murtaza, Robin Scharrenberg, Sean H. White, Ole Johanns, S. Walker, R. Yuen, B. Schwanke, B. Bedürftig, Melad Henis, Sarah Scharf, Vanessa Kraus, Ronja Dörk, Jakob Hellmann, Z. Lindenmaier, J. Ellegood, H. Hartung, Vickie Kwan, J. Sedlacik, J. Fiehler, M. Schweizer, J. Lerch, I. Hanganu-Opatz, F. Morellini, S. Scherer, Karun K. Singh, Froylan Calderon de Anda   +26 more
semanticscholar   +1 more source

Survival of the resilient: Mechano-adaptation of circulating tumor cells to fluid shear stress

Molecular & Cellular Oncology, 2020
During metastasis, cancer cells traverse the circulation to reach distant organs. Conventionally, this journey has been regarded as mechanically destructive to circulating tumor cells from solid tissues.
Devon L. Moose, Michael D. Henry
doaj   +1 more source

RhoA of the Rho family small GTPases is essential for B lymphocyte development. [PDF]

PLoS ONE, 2012
RhoA is a member of the Rho family small GTPases that are implicated in various cell functions including proliferation and survival. However, the physiological role of RhoA in vivo remains largely unknown.
Shuangmin Zhang, Xuan Zhou, Richard A Lang, Fukun Guo   +3 more
doaj   +1 more source

RhoA G17V is sufficient to induce autoimmunity and promotes T-cell lymphomagenesis in mice.

Blood, 2018
Patients with angioimmunoblastic T-cell lymphoma (AITL) and other peripheral T-cell lymphomas that harbor features of follicular helper T (TFH) cells have a very poor prognosis.
S. Ng, L. Brown, K. Stevenson, Tiffany DeSouza, J. Aster, A. Louissaint, D. Weinstock   +6 more
semanticscholar   +1 more source

Meningitic Escherichia coli Induction of ANGPTL4 in Brain Microvascular Endothelial Cells Contributes to Blood–Brain Barrier Disruption via ARHGAP5/RhoA/MYL5 Signaling Cascade

Pathogens, 2019
Bacterial meningitis is currently recognized as one of the most important life-threatening infections of the central nervous system (CNS) with high morbidity and mortality, despite the advancements in antimicrobial treatment.
Lu Liu, Jixuan Li, Dong Huo, Zhong Peng, Ruicheng Yang, Jiyang Fu, Bojie Xu, Bo Yang, Huanchun Chen, Xiangru Wang   +9 more
doaj   +1 more source

A mechanosensitive RhoA pathway that protects epithelia against acute tensile stress

bioRxiv, 2018
Adherens junctions are tensile structures that couple epithelial cells together. Junctional tension can arise from cell-intrinsic application of contractility or from the cell-extrinsic forces of tissue movement.
Bipul R. Acharya, Alexander Nestor-Bergmann, Xuan Liang, Srikanth Budnar, O. Jensen, Z. Bryant, A. Yap   +6 more
semanticscholar   +1 more source